| Title: |
Challenges in Liver Transplantation for Hepatocellular Carcinoma: A Review of Current Controversies |
| Authors: |
Mauro, Ezequiel; Sanduzzi-Zamparelli, Marco; Jutras, Gabrielle; Garcia, Raquel; Perromat, Alexandre Soler; Llarch, Neus; Arce, Victor Holguin; Ruiz, Pablo; Rimola, Jordi; Lopez, Eva; Ferrer-Fàbrega, Joana; García-Criado, Ángeles; Colmenero, Jordi; Lai, Jennifer C; Forner, Alejandro |
| Source: |
Cancers, vol 16, iss 17 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2024 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 3211 Oncology and Carcinogenesis (for-2020); Organ Transplantation (rcdc); Liver Cancer (rcdc); Liver Disease (rcdc); Cancer (rcdc); Transplantation (rcdc); Digestive Diseases (rcdc); Chronic Liver Disease and Cirrhosis (rcdc); Rare Diseases (rcdc); Cancer (hrcs-hc); 3 Good Health and Well Being (sdg); liver transplantation; hepatocellular carcinoma; immunotherapy; comorbidities; frailty; immunosuppression management; recurrence surveillance; multidisciplinary care; 1112 Oncology and Carcinogenesis (for) |
| Time: |
3059 |
| Description: |
Liver transplantation (LT) remains one of the most effective treatments for hepatocellular carcinoma (HCC) and significantly enhances patient survival. However, the application of LT for HCC faces challenges owing to advancements in cancer-specific treatment modalities and the increased burden of patients' comorbidities. This narrative review explores current controversies and advancements in LT for HCC. Key areas of focus include the management of comorbidities and patient education by advanced practice nurses, impacts of frailty on waitlists and post-LT outcomes, selection criteria for LT in the era of new downstaging tools, role of radiology in patient selection, and implications of potential immunotherapy use both before and after LT. Additionally, the importance of immunosuppression management with strategies aimed at minimizing rejection while considering the risk of HCC recurrence and the role of surveillance for HCC recurrence is highlighted. This review also underscores the importance of a multidisciplinary approach for optimizing outcomes in patients with HCC undergoing LT. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt2qw7w96w; https://escholarship.org/uc/item/2qw7w96w; https://escholarship.org/content/qt2qw7w96w/qt2qw7w96w.pdf |
| DOI: |
10.3390/cancers16173059 |
| Availability: |
https://escholarship.org/uc/item/2qw7w96w; https://escholarship.org/content/qt2qw7w96w/qt2qw7w96w.pdf; https://doi.org/10.3390/cancers16173059 |
| Rights: |
CC-BY |
| Accession Number: |
edsbas.30088343 |
| Database: |
BASE |