| Title: |
Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study ; BMC Cancer |
| Contributors: |
Park, Hannah Lui; Ziogas, Argyrios; Chang, Jenny; Desai, Bhumi; Bessonova, Leona; Garner, Chad; Lee, Eunjung; Neuhausen, Susan L.; Wang, Sophia S.; Ma, Huiyan; Clague, Jessica; Reynolds, Peggy; Lacey, James V.; Bernstein, Leslie; Anton-Culver, Hoda |
| Source: |
BMC Cancer. 16. |
| Collection: |
CDC Stacks (Centers for Disease Control and Prevention) |
| Subject Terms: |
Research Article; Breast cancer; Single nucleotide polymorphism; Caspase-8 |
| Description: |
Background ; The ability of tamoxifen and raloxifene to decrease breast cancer risk varies among different breast cancer subtypes. It is important to determine one’s subtype-specific breast cancer risk when considering chemoprevention. A number of single nucleotide polymorphisms (SNPs), including one in caspase-8 (CASP8), have been previously associated with risk of developing breast cancer. Because caspase-8 is an important protein involved in receptor-mediated apoptosis whose activity is affected by estrogen, we hypothesized that additional SNPs in CASP8 could be associated with breast cancer risk, perhaps in a subtype-specific manner. ; Methods ; Twelve tagging SNPs of CASP8 were analyzed in a nested case control study (1,353 cases and 1,384 controls) of non-Hispanic white women participating in the California Teachers Study. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated for each SNP using all, estrogen receptor (ER)-positive, ER-negative, human epidermal growth factor receptor 2 (HER2)-positive, and HER2-negative breast cancers as separate outcomes. ; Results ; Several SNPs were associated with all, ER-positive, and HER2-positive breast cancers; however, after correcting for multiple comparisons (i.e., p  |
| Document Type: |
other/unknown material |
| Language: |
unknown |
| Relation: |
cdc:40955; http://stacks.cdc.gov/view/cdc/40955/ |
| Availability: |
http://stacks.cdc.gov/view/cdc/40955/ |
| Accession Number: |
edsbas.3027BC49 |
| Database: |
BASE |