| Title: |
Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome : multicentre study from the Prospective Lynch Syndrome Database |
| Authors: |
Zalevskaja, K.; Ojala, K.; Petrov, A.; Haupt, S.; Sunde, L.; Bernstein, I.; Jenkins, M. A.; Aretz, S.; Nielsen, M.; Capella, G.; Balaguer, F.; Evans, D. G.; Burn, J.; Holinski-Feder, E.; Bertario, L.; Bonanni, B.; Lindblom, A.; Levi, Z.; Macrae, F.; Winship, I; Plazzer, J-P; Sijmons, R.; Laghi, L.; Della Valle, A.; Heinimann, K.; Debniak, T.; Fruscio, R.; Lopez-Koestner, F.; Alvarez-Valenzuela, K.; Katz, L. H.; Laish, I; Vainer, E.; Vaccaro, C.; Carraro, D. M.; Monahan, K.; Half, E.; Stakelum, A.; Winter, D.; Kennelly, R.; Gluck, N.; Sheth, H.; Abu-Freha, N.; Greenblatt, M.; Rossi, B. M.; Bohorquez, M.; Cavestro, G. M.; Lino-Silva, L. S.; Horisberger, K.; Tibiletti, M. G.; do Nascimento, I; Thomas, H.; Rossi, N. T.; da Silva, L. A.; Zarand, A.; Ruiz-Banobre, J.; Heuveline, V; Lindberg, L. J.; Gogenur, I; Hopper, J. L.; Win, A. K.; Haile, R. W.; Lindor, N.; Gallinger, S.; Le Marchand, L.; Newcomb, P. A.; Figueiredo, J.; Buchanan, D. D.; Thibodeau, S. N.; Knebel Doeberitz, M.; Loeffler, M.; Rahner, N.; Schroeck, E.; Steinke-Lange, V; Schmiegel, W.; Vangala, D.; Perne, C.; Hueneburg, R.; Redler, S.; Buettner, R.; Weitz, J.; Pineda, M.; Duenas, N.; Brunet Vidal, J.; Moreira, L.; Sanchez, A.; Castillo-Iturra, J.; Hovig, E.; Green, K.; Lalloo, F.; Hill, J.; Crosbie, E.; Mints, M.; Goldberg, Y.; Tjandra, D.; ten Broeke, S. W.; Kariv, R.; Rosner, G.; Jain, A.; Shah, P.; Shah, M.; Neffa, F.; Esperon, P.; Pavicic, W.; Torrezan, G. T.; Bassaneze, T.; Martin, C. A.; Pylvanainen, K.; Moeslein, G.; Lepistö, A.; Mecklin, J-P; Renkonen-Sinisalo, L.; Sampson, J. R.; Dominguez Valentin, M.; Moller, P.; Seppälä, T. T. |
| Contributors: |
University of Helsinki; Research Programs Unit; Clinicum; ATG - Applied Tumor Genomics; HUS Abdominal Center; II kirurgian klinikka; Department of Surgery |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2025 |
| Collection: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| Subject Terms: |
Colon-cancer; Guidelines; Management; Colectomy; Surgery; Survival; Genetics; anesthesiology; intensive care; radiology |
| Description: |
This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch Syndrome Database version 5. Extended resection significantly reduced the risk of metachronous CRC in path_MLH1, path_MSH2, and path_MSH6 carriers compared to segmental resection. ; Peer reviewed |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Kristina Zalevskaja was supported by the William, Bertta and Erkki Lylys Foundation and the South Savo Regional Fund. Toni T. Seppaelae was supported by the Cancer Foundation Finland (grant 63-6409), the Jane and Aatos Erkko Foundation (grant 21002), the Relander Foundation, the Sigrid Juselius Foundation (grant 240194), the Academy of Finland (grant 338657), the iCAN Precision Medicine Flagship of the Academy of Finland (grant 346555), and state research funding through the HUS (grant TYH2022323) and Pirkanmaa Welfare Area (Pirha, grants T63354 and T66854). Julian R. Sampson was supported by Health Care Research Wales via a grant to Wales Gene Park. John-Paul Plazzer has received funding support from the RMH Allan Watt and Chris Geyer Oncology Fellowship. Dafydd Gareth Evans is supported by the Manchester National Institute for Health Research (NIHR) Biomedical Research Centre (ISBRC-1215-20007). The German Consortium for Familial Intestinal Cancer was supported by grants from German Cancer Aid. Gabriel Capella, Joan Brunet Vidal, and Marta Pineda were funded by the Spanish Ministry of Science and Innovation and co-founded by FEDER M.D. Catalonia (grant 2017SGR1282). Gabriel Capella was supported by the Spanish Ministry of Economy and Competitiveness and the Spanish Ministry of Science and Innovation, co-funded by FEDER funds (PID2019-111254RB-I00; IMPaCT Genomica IMP/0009) and CIBERONC (CB16/12/00234), and the Government of Catalonia. Gabriel Capella thanks the CERCA Programme for institutional support. Finlay Macrae is supported by a Synergy Grant (2021/GNT2010268), Targeted Research (2021/GNT2014703), Cancer Australia (Capp3), and the Victorian Cancer Agency (Capp3, 2016.339). Deepak Vangala is supported by German Cancer Aid. Sanne W. ten Broeke is supported by The Dutch Cancer Society grant for research. Juan Ruiz-Banobre is supported by Instituto de Salud Carlos III, Ministerio de Ciencia e Innovacion-Juan Rodes contract (JR21/00019) and a 2020 TTD Research Grant from the Spanish Cooperative Group for the Treatment of Digestive Tumours. Harsh Sheth contributed with support from the Gujarat State Biotechnology Mission (GSBTM/JDR&D/604/2019/299 and GSBTM/JDR&D/663/2023-24/02003575). Dirce Maria Carraro and Giovana Tardin Torrezan were funded by the Sao Paulo Research Foundation (FAPESP grant number 2014/50943-1) and the National Council for Scientific and Technological Development (CNPq grant number 465682/2014-6). Kevin Monahan was funded by the 40tude charity for the Lynch Cancer (LynC) Prevention Study, UK. The work by Maartje Nielsen was funded by the Dutch Digestive Foundation (FP16-06). Luigi Laghi reports a relationship with the Humanitas Clinical and Research Centre, University of Parma.; https://hdl.handle.net/10138/596286; 105003688410; 001466497900001 |
| Availability: |
https://hdl.handle.net/10138/596286 |
| Rights: |
cc_by ; info:eu-repo/semantics/openAccess ; openAccess |
| Accession Number: |
edsbas.3060FAE0 |
| Database: |
BASE |