| Title: |
Quantitative Risk for Single-Positive Lupus Anticoagulant Results With Different Anticoagulants |
| Authors: |
Khan, Waleed; Tormey, Christopher A; Rinder, Henry M; Siddon, Alexa J |
| Source: |
American Journal of Clinical Pathology ; volume 159, issue 5, page 417-419 ; ISSN 0002-9173 1943-7722 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2023 |
| Description: |
Objectives Clinical experts recommend against testing for lupus anticoagulant (LAC) during anticoagulation. Methods We quantitated the risk of a single-positive dilute Russell viper venom time (dRVVT) result or partial thromboplastin time–based phospholipid neutralization (PN) result on anticoagulation. Results Any anticoagulation led to a fourfold greater likelihood of single-positive results, primarily by rivaroxaban (odds ratio [OR] = 8.6) and warfarin (OR = 6.6), resulting in a positive dRVVT test with a normal PN test. Heparin and apixaban were twofold more likely to show single-positive results, but enoxaparin did not show significant single positivity. Conclusions Our results quantitatively support experts’ avoidance of LAC testing during anticoagulation. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ajcp/aqac183 |
| Availability: |
https://doi.org/10.1093/ajcp/aqac183; https://academic.oup.com/ajcp/article-pdf/159/5/417/50149872/aqac183.pdf |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.30C63240 |
| Database: |
BASE |