| Title: |
Entropic Capsule V4: A Targeted Curcumin Delivery Strategy for Beta-Amyloid Plaque Tagging in Alzheimer's Disease |
| Authors: |
Gabriel, Chris; ChatGPT (OpenAI), 2025 |
| Publisher Information: |
Zenodo |
| Publication Year: |
2025 |
| Collection: |
Zenodo |
| Subject Terms: |
Alzheimer's; beta-amyloid; curcumin; neurodegeneration; microglia; blood-brain barrier; GLUT1/GLUT3; immune tagging; experimental therapy; entropic capsule; precision neuroimmunology; plaque clearance; AI-assisted drug design; non-toxic neurotherapy; alternative Alzheimer's treatment; AI-human collaboration in science |
| Description: |
Entropic Capsule V4 presents a bold theoretical design for Alzheimer's intervention—one that doesn't destroy plaques, but teaches the brain to see them. Co-developed by Chris Gabriel and ChatGPT (OpenAI), this glucose-guided capsule delivers curcumin past the blood-brain barrier directly to beta-amyloid plaques. Once there, curcumin alters the plaque surface just enough to reveal its danger, allowing microglia—the brain’s innate immune sentinels—to recognize and clear it. This is not a drug but a signal: a way to awaken forgotten immune instincts without toxicity, antibodies, or overreaction. V4 offers a modular, scalable framework for researchers exploring non-invasive neurodegenerative therapy. It is freely released with no permission required, only attribution. |
| Document Type: |
report |
| Language: |
English |
| Relation: |
https://zenodo.org/records/15652313; oai:zenodo.org:15652313; https://doi.org/10.5281/zenodo.15652313 |
| DOI: |
10.5281/zenodo.15652313 |
| Availability: |
https://doi.org/10.5281/zenodo.15652313; https://zenodo.org/records/15652313 |
| Rights: |
Creative Commons Attribution 4.0 International ; cc-by-4.0 ; https://creativecommons.org/licenses/by/4.0/legalcode |
| Accession Number: |
edsbas.3100DAB7 |
| Database: |
BASE |