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Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure

Title:	Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure
Authors:	Teerlink J. R.; Diaz R.; Michael Felker G.; McMurray J. J. V.; Metra M.; Solomon S. D.; Adams K. F.; Anand I.; Arias-Mendoza A.; Biering-Sorensen T.; Bohm M.; Bonderman D.; Cleland J. G. F.; Corbalan R.; Crespo-Leiro M. G.; Dahlstrom U.; Echeverria L. E.; Fang J. C.; Filippatos G.; Fonseca C.; Goncalvesova E.; Goudev A. R.; Howlett J. G.; Lanfear D. E.; Li J.; Lund M.; Macdonald P.; Mareev V.; Momomura S.; O'Meara E.; Parkhomenko A.; Ponikowski P.; Ramires F. J. A.; Serpytis P.; Sliwa K.; Spinar J.; Suter T. M.; Tomcsanyi J.; Vandekerckhove H.; Vinereanu D.; Voors A. A.; Yilmaz M. B.; Zannad F.; Sharpsten L.; Legg J. C.; Varin C.; Honarpour N.; Abbasi S. A.; Malik F. I.; Kurtz C. E. GALACTIC-HF Investigators: John R Teerlink; Rafael Díaz; Rosario Santa Fe; G Michael Felker; John J V McMurray; Marco Metra; Scott D Solomon; Fady I Malik; Christopher E Kurtz; Siddique Abbasi; Beat Knusel; Thomas Hucko; John Groarke; Narimon Honarpour; Jason C Legg; Lucie Sharpsten; Claire Varin; Marvin A Konstam; Javed Butler; Henry Dargie; Joseph Massaro; Barry H Greenberg; James L Januzzi; Lawrence J Lesko; Jenica N Upshaw; Renato Lopes; W Schuyler Jones; Karen P Alexander; Sana M Al-Khatib; Robert W Harrison; J Dedrick Jordan; David F Kong; Robin Mathews; Robert W McGarrah; Rajendra H Metha; Chiara Melloni; Thomas J Povsic; Shreyansh Shah; Brian Claggett; Kirkwood Adams; Inder Anand; Alexandra Arias Mendoza; Tor Biering-Sørensen; Michael Böhm; Diana Bonderman; John Cleland; Ramon Corbalan Herreros; Marisa Crespo Leiro; Ulf Dahlstrom; Rafael Diaz; Luis Eduardo Echeverria; James Fang; Gerasimos Filippatos; Candida Fonseca; Eva Goncalvesova; Assen Goudev; Jonathan Howlett; Lixin Jiang; David Lanfear; Jing Li; Mayanna Lund; Viacheslav Mareev; Shin-Ichi Momomura; Eileen O'Meara; Alexander Parkhomenko; Piotr Ponikowski; Felix Ramires; Pranas Serpytis; Karen Sliwa; Jindrich Spinar; Thomas Suter; Janos Tomcsanyi; Hans Vandekerckhove; Dragos Vinereanu; Carol Davila; Adriaan Voors; Mehmet Birhan Yilmaz; Faiez Zannad; Diego Alejandro Besada; Claudio Rodolfo Majul; Marcos Raul Litvak Bruno; Sonia Sassone; Horacio Alberto Avaca; Mariela Rasmussen; Jorge Roberto Aiub; Miguel Angel Hominal; Eduardo Perna; Ruben Omar Garcia Duran; Lilia Schiavi; Lilia Luz Lobo Marquez; Oscar Alberto Gomez Vilamajo; Ignacio Mackinnon; Ricardo Alfonso Leon de la Fuente; Oscar Romano Montana; Leonardo Novaretto; Rodolfo Andres Ahuad Guerrero; Daniela Garcia Brasca; Aldo Prado; Marcelo Alejandro Garrido; Hugo Luquez; Diego Felipe Martinez; Liliana Nicolosi; Maria Leonor Parody; Cesar Zaidman; Fernando Colombo Berra; Julio Ibañez; Gerardo Zapata; Marcos Amuchastegui; Alberto Caccavo; Roberto Colque; Mirta Diez; Carlos Poy; Oscar Alejandro Salomone; Daniel Vogel; Anselmo Paulino Bordonava; Alberto Fernandez; John French; John Atherton; Andrew Hamilton; Alistair Begg; Walter Abhayaratna; Christopher Judkins; Peter Macdonald; Carmine De Pasquale; Scott McKenzie; John Amerena; Gregory Szto; Leighton Kearney; Hendrik Zimmet; Aaron Sverdlov; John Beltrame; Dariusz Korczyk; Andrew Sindone; Deddo Moertl; Kurt Huber; Martin Huelsmann; Gabriele Jakl-Kotauschek; Klemens Ablasser; Friedrich Fruhwald; Christian Ebner; Peter Siostrzonek; Heinz Drexel; Gerhard Poelzl; Karl Dujardin; Matthias Dupont; Ian Buysschaert; Patrizio Lancellotti; Luc Pierard; Walter Droogne; Iman Chouchane; Fabio Silveira; Salvador Rassi; Gilmar Reis; Pedro Pimentel Filho; Marcus Vinicius Simoes; Joao Carlos Braga; Flavio Eduardo Giorgeto; Norberto Duda; Almir Ferraz; Cristiano Pederneiras Jaeger; Rafael Luiz Rech; Jose Francisco Saraiva; Alexandre Tognon; Juliano Cardoso; Oswaldo Greco; Maria Sanali Paiva; Bruno Paolino; Otavio Coelho Filho; Lilia Nigro Maia; Rodrigo da Silva; Manoel Canesin; Paulo Roberto Ferreira Rossi; Lidia Ana Zytynski Moura; Jose Augusto Ribas Fortes; Rodrigo Julio Cerci; Euler Roberto Fernandes Manenti; Paulo Ernesto Leaes; Luis Beck da Silva Neto; Weimar Kunz Barroso de Souza; Fernando Bacal; Renato Chaves; Maria Helena Vidotti; Flavio Brito; Pedro Gabriel Melo de Barros E Silva; Leopoldo Soares Piegas; Georgi Todorov; Maria Tzekova; Valentina Mincheva; Aleksandra Manolova; Ivaylo Vasilev; Snezhanka Tisheva-Gospodinova; Ivo Petrov; Arman Postadzhiyan; Chavdar Velikov; Bojidar Dimov; Christian Constance; Denis-Carl Phaneuf; Lisa Mielniczuk; A Shekhar Pandey; Manohara Senaratne; Shelley Zieroth; Daniel Savard; Robert Stewart; Thao Huynh; Abdul Al-Hesayen; Nadia Giannetti; Gordon Moe; Ronald Bourgeois; Justin Ezekowitz; Michael Hartleib; Bruce Sussex; Mohan Babapulle; Raja Chehayeb; Daniel Gaudet; Robert McKelvie; Viviane Nguyen; Sherryn Roth; Milan Gupta; Yves Pesant; Dennis Rupka; Rakesh Bhargava; Atilio Costa-Vitali; Guy Proulx; Mario Vega; Sergio Potthoff; Maria Cristina Schnettler Cid; Alex Mauricio Villablanca Sepulveda; Fernando Tomas Lanas Zanetti; Ramon Corbalan; Victor Areli Saavedra Gajardo; Carlos Conejeros Kindel; Christian Paolo Pincetti Jofre; Jorge Leonardo Cobos Segarra; Manuel Eduardo Rodriguez Venegas; Mario Yanez Hidalgo; Margarita Gertrudis Vejar Jalaf; Weimin Li; Jinguo Zhang; Xin Fu; Xuelian Zhang; Dongye Li; Zhifang Wang; Yanling Qu; Zhe Zheng; Huifang Tang; Ping Yang; Yuhui Zhang; Yang Zheng; Yafei Mi; He Huang; Peili Bu; Guoqin Chen; Jiyan Chen; Yajun Han; Zhanquan Li; Shumei Ma; Xuming Yang; Zuyi Yuan; Yugang Dong; Zhaoping Li; Ailiman Mahemuti; Wentang Niu; Zhenyu Yang; Yuqing Zhang; Yuemin Sun; Weiheng Wu; Feng Liu; Jing Yan; Yinjun Li; Yi Wang; Shouyan Zhang; Changyong Zhou; Hanbin Cui; Jianjun Li; Tianfa Li; Qinghua Han; Yu Wei; Fernando Manzur Jattin; Jose Luis Accini Mendoza; Wilder Castaño Osorio; Gregorio Sanchez Vallejo; Carlos Alberto Luengas; Julian Alonso Coronel Arroyo; Miguel Alfredo Moncada Corredor; Clara Ines Saldarriaga Giraldo; Rodrigo Botero Lopez; Dora Ines Molina de Salazar; Miguel Urina Triana; Luis Horacio Atehortua Lopez; Pastor Olaya Rojas; Sebastian Velez Pelaez; Monica Lopez Pareja; Alberto Cadena Bonfanti; Rostislav Polasek; Zdenek Monhart; Karel Sochor; Zuzana Motovska; Jan Belohlavek; Ladislav Busak; Jiri Krupicka; Petr Tyl; Ondrej Jerabek; Ivo Podpera; Janka Skrobakova; Karel Peterka; Rudolf Spacek; Vladimir Cech; Ivana Kellnerova; Libor Nechvatal; Zbynek Pozdisek; Marek Houra; Radim Kryza; Vilma Machova; Tomas Brabec; Michal Cepelak; David Stepek; Kamil Zeman; Zdenek Klimsa; Pavel Koleckar; Alexandr Schee; Lenka Spinarova; Zdenek Coufal; Jorgen Jeppesen; Soren Vraa; Henrik Wiggers; Ole Nyvad; Tonny Nielsen; Niels Gadsboll; Peter Kaiser-Nielsen; Jacob Eifer Moller; Lars Videbaek; Michel Galinier; Jean-Marie Lefebvre; Jean-Michel Tartiere; Guillaume De Geeter; Francois Roubille; Jean Etienne Ricci; Muriel Salvat; Jean-Pierre Gueffet; Eric Decoulx; Philippe Berdague; Guillaume Jondeau; Nathan Mewton; Michel Ovize; Pascal De Groote; Erwan Donal; Richard Isnard; Rémi Sabatier; Jean-Noel Trochu; Thibaud Damy; Jean-Louis Georges; Yann Rosamel; François Picard; Victor Aboyans; Thierry Laperche; Veselin Mitrovic; Jens Taggeselle; Stefan Störk; Henning Ebelt; Sabine Genth-Zotz; Tienush Rassaf; Hans-Dirk Duengen; Marcus Mittag; Niels Menck; Stephan von Haehling; Uwe Zeymer; Michael Boehm; Lutz Frankenstein; Holger Killat; Hakima Bourhaial; Daniel Beug; Thomas Horacek; Roman Pfister; Marcus Sandri; Ralf Westenfeld; Christoph Kadel; Haralambos Karvounis; Sotirios Patsilinakos; Ioannis Mantas; Apostolos Karavidas; Grigorios Giamouzis; Konstantinos Tsioufis; Katerina Naka; Dimitrios Tziakas; John Parissis; Ioannis Styliadis; Ioannis Barbetseas; Athanasios Manolis; George Kochiadakis; Fragkiskos Parthenakis; Bela Herczeg; Laszlo Nagy; Noemi Nyolczas; Kalman Toth; Bela Merkely; Zoltan Laszlo; Laszlo Mark; Imre Szakal; Andras Papp; Katalin Bezzegh; Eva Peterfai; Ferenc Lakatos; Erik Hajko; Aniko Papp; Tamas Forster; Geza Lupkovics; Attila Mohacsi; Csaba Salamon; Daniel Aradi; Peter Andreka; Gyula Szasz; Zsolt Zilahi; Rita Kazinczy; Alberto Margonato; Piergiuseppe Agostoni; Alessandro Fucili; Giancarlo Piovaccari; Michele Senni; Giuseppe Ambrosio; Erberto Carluccio; Claudio Bilato; Maria Frigerio; Ciro Indolfi; Gianfranco Sinagra; Natale Daniele Brunetti; Matteo Di Biase; Gianpiero Perna; Daniela Pini; Maurizio Volterrani; Gaetano Maria De Ferrari; Sergio Leonardi; Claudia Raineri; Felice Achilli; Domenico Bonaduce; Andrea Mortara; Giuseppe Musumeci; Hernan Emilio Francisco Polo Friz; Roberta Rossini; Carlo Gabriele Tocchetti; Antonella Vincenzi; Claudio Cavallini; Agata Marina Floresta; Valerio Zaca; Vittorio Giudici; Giovanni Quinto Villani; Yorihiko Higashino; Shogo Oishi; Atsuyuki Wada; Yoshinori Yasaka; Shigeru Fukuzawa; Hiroyuki Kawata; Kenji Onoue; Yoshihiko Saito; Akihiro Koike; Tomomi Koizumi; Seigo Masuda; Hiroshi Meno; Kazuhisa Mitsuo; Kumiko Nakayama; Shuichi Taguchi; Natsuki Takahashi; Takashi Takenaka; Jun Tanabe; Hideyuki Tsuboi; Naoki Watanabe; Takeshi Yoshida; Tetsuya Amano; Masahiro Ishikawa; Keisuke Kida; Toru Kubota; Kentaro Nakamura; Tomohiro Sakamoto; Naoki Sato; Mitsuhiro Shimomura; Hiroki Uehara; Fumi Yamamoto; Masaru Yuge; Yutaka Akatsuka; Masayuki Doi; Hiroshi Domae; Mio Ebato; Kenshi Fujii; Wakaya Fujiwara; Seiichiro Gohara; Yoshiki Hata; Atsushi Hirayama; Hideo Izawa; Shuntaro Kagiyama; Junji Kanda; Hiroaki Kitaoka; Hiroaki Kiyokawa; Kunihiko Makino; Takashi Matsumoto; Ichiro Michishita; Shinichiro Miura; Tetsuro Miyazaki; Makoto Nakahama; Akihiro Nakamura; Yuji Nakazato; Tomohiro Ogawa; Takahiro Okumura; Yasuo Okumura; Tetsuo Sakai; Keijiro Saku; Yukihito Sato; Wataru Shimizu; Hiroshi Sugino; Masahiro Suzuki; Atsutoshi Takagi; Hiroshi Takaishi; Takahiro Tanaka; Toshiro Terasaki; Mitsuru Tsujimoto; Yasunori Ueda; Keiji Ujino; Makoto Usui; Mitsutaka Yamamoto; Masaki Yoshikawa; Masayoshi Ajioka; Kenji Ando; Masanori Asakura; Hiroshi Asano; Shigeru Fujii; Hisao Hara; Takayuki Inomata; Takaaki Isshiki; Toshiaki Kadokami; Hisashi Kai; Toshio Kasai; Katsunori Kawamitsu; Tomohiro Kawasaki; Tokushi Koga; Nobuyuki Komiyama; Yasuhiro Maejima; Mamoru Manita; Nobuhide Miyamoto; Kimiaki Nagase; Koichi Node; Kotaro Numaguchi; Yasushi Sakata; Takeshi Serikawa; Koichiro Sugimura; Noriaki Takama; Shunsuke Tatebe; Hideki Ueno; Yoshitoshi Urabe; Takayuki Hidaka; Shitoshi Hiroi; Harukazu Iseki; Hiroshi Ito; Kouji Kajinami; Hideo Kawakami; Yasuki Kihara; Yukihiko Momiyama; Masuki Mori; Yukiko Morita; Kaoru Okishige; Satoru Sakagami; Yasuchika Takeishi; Akihiro Terasawa; Noriaki Utsu; Jolita Badariene; Jelena Celutkiene; Gintare Sakalyte; Rimvydas Slapikas; Dalia Jarasuniene; Armando Garcia Castillo; Manuel Odin De Los Rios Ibarra; Gabriel Arturo Ramos Lopez; Edmundo Alfredo Bayram Llamas; Guillermo Antonio Llamas Esperon; Eduardo Salcido Vazquez; Ricardo Garcia Gonzalez; Jose Luis Arenas Leon; Salvador Leon Gonzalez; Maria Alexandra Arias Mendoza; Alicia Contreras Rodriguez; Gustavo Francisco Mendez Machado; Melchor Alpizar Salazar; Alberto Esteban Bazzoni Ruiz; Ana Maria De Leon Flores; Jose Alfredo Pagola Carrasco; Raul Reyes Araiza; Tjeerd Römer; Johannes Remmen; Jacob Van Eck; Arif Elvan; Elvin Kedhi; Tom Smilde; Ruud van de Wal; Dirk Lok; Jeroen Schaap; Aize van der Sluis; Gerardus Linssen; Michael Magro; Frank Willems; Dirk Schellings; Coenraad van der Zwaan; John van Hal; Driek Beelen; Dirk Boswijk; Walter Hermans; Pascalle van Huysduynen-Monraats; Henricus Van Kesteren; Russell Scott; Hamish Hart; Marcin Szczasny; Tomasz Blicharski; Mariusz Kafara; Anna Stankiewicz; Grzegorz Skonieczny; Maciej Zabowka; Grzegorz Kania; Tomasz Borkowski; Jerzy Kopaczewski; Lidia Pawlowicz; Janusz Spyra; Aleksander Wlodarczyk; Ryszard Sciborski; Pawel Balsam; Jaroslaw Drozdz; Bozena Sobkowicz; Malgorzata Konieczynska; Malgorzata Lelonek; Zbigniew Bednarkiewicz; Jaroslaw Trebacz; Piotr Jankowski; Mateusz Sidor; Piotr Berkowski; Zbigniew Chmielak; Lucyna Lenartowska; Jadwiga Nessler; Ewa Straburzynska-Migaj; Zbigniew Kalarus; Robert Kowalski; Ewa Kalecinska-Krystkiewicz; Zbigniew Gola; Zbigniew Pijanowski; Beata Wozakowska-Kaplon; Krzysztof Cymerman; Andrzej Rynkiewicz; Pawel Miekus; Pedro Monteiro; Pedro Morais Sarmento; Filipa Almeida; Tatiana Duarte; Luis Oliveira; Sara Soares Goncalves; Luis Santos; Dulce Brito; Gabriela Stanciulescu; Marilena Renata Spiridon; Constantin Militaru; Cristian Gheorghe Podoleanu; Dumitru Zdrenghea; Mircea Ioachim Popescu; CezarEugen Macarie; Alina Giuca; Florin Mitu; Olga-Cristina Voicu; Maria Dorobantu; Daniel Lighezan; Sorin Stamate; Alexander Bykov; Zhanna Kobalava; Konstantin Zrazhevskiy; Irina Semenova; Alexander Vishnevsky; Elena Shutemova; Sergey Tereschenko; Yury Shvarts; Olga Barbarash; Yury Lukyanov; Mikhail Voevoda; Svetlana Dovgolis; Dmitry Dronov; Boris Goloshchekin; Maria Sitnikova; Marat Ezhov; Nikolay Tarasov; Mikhail Kotelnikov; Viktor Kostenko; Oleg Solovev; Sergey Boytsov; Ivan Goncharov; Roman Myasnikov; Svetlana Villevalde; Vladimir Rafalskiy; Vyacheslav Ryabov; Elena Kosmacheva; Igor Motylev; Vladimir Nosov; Irina Osipova; Vladimir Salukhov; Dmitriy Belenkiy; Olga Bolshakova; Leonid Pimenov; Nataliya Shilkina; Elena Kulibaba; Vyacheslav Mareev; Alexey Repin; Alexander Timofeev; Vladislav Mitrokhin; Valery Popov; Alexander Sherenkov; Georgy Arbolishvili; Lubomir Antalik; Andrej Dzupina; Peter Fulop; Ivan Majercak; Jozef Gonsorcik; Daniela Vinanska; Egon Lenner; Jana Lukacova; Roman Margoczy; Rudolf Smik; Jan Stevlik; Rudolf Uhliar; Lesley Burgess; Aysha Badat; Eric Klug; Louis Van Zyl; Mark Abelson; Rajendran Moodley; Nqoba Tsabedze; Nyda Fourie; Luis Almenar Bonet; Jose Maria Arizon Del Prado; Manuel Martinez-Selles D Oliveira Soares; Julio Eduardo Nuñez Villota; Maria Generosa Crespo Leiro; Jose Ramon Gonzalez Juanatey; Domingo Andres Pascual Figal; Juan Luis Bonilla Palomas; Sonia Mirabet Perez; Juan Francisco Delgado Jimenez; Antonio Lara Padron; Andres Iñiguez Romo; Victor Alfonso Jimenez Diaz; Fernando Soto Loureiro; Javier Segovia Cubero; Antonio Juan Castro Fernandez; Vicente Eduardo Climent Paya; Alejandro Recio Mayoral; Luis de la Fuente Galan; Juan Jose Gomez Doblas; Ramon Bover Freire; Maria Teresa Blasco Peiro; Beatriz Diaz Molina; Laura Jordan Martinez; Jose Luis Lambert Rodriguez; Silvia Lopez Fernandez; Francisco Gonzalez Vilchez; Kurt Boman; Patric Karlstrom; Stefan Berglund; Barna Szabo; Magnus Peterson; Peter Wodlin; Carl-Johan Lindholm; Tiziano Moccetti; Christian Mueller; Roger Hullin; Philippe Meyer; Georg Noll; Zerrin Yigit; Okan Onur Turgut; Lutfu Bekar; Tayfun Sahin; Zehra Lale Koldas; Ahmet Celik; Yuksel Cavusoglu; Mesut Demir; Ersel Onrat; Mehmet Duzenli; Kahraman Cosansu; Mustafa Vural; Ibrahim Haldun Muderrisoglu; Mustafa Tuncer; Ozer Badak; Sanem Nalbantgil; Cevat Kirma; Ertugrul Okuyan; Umit Guray; Oleksandr Prokhorov; Oleksandr Karpenko; Igor Vakaliuk; Andriy Yagensky; Igor Kraiz; Mykola Stanislavchuk; Oleksii Kulynych; Mykola Rishko; Roman Stets; Vira Tseluyko; Larysa Mishchenko; Leonid Rudenko; Yevgeniya Svishchenko; Iurii Rudyk; Liudmyla Alieksieieva; Oleksii Korzh; Yuriy Mostovoy; Dmytro Reshotko; Oleksandr Parkhomenko; Lesya Rasputina; Leonid Voronkov; Georgiy Dzyak; Yurii Lymar; Larysa Vasilyeva; Philip Keeling; Craig Barr; Kenneth Wong; Dallas Price; Binoy Skaria; Andrew Clark; Badrinathan Chandrasekaran; Jasper Trevelyan; Brian Gordon; Patrick Donnelly; Jason Glover; Alisdair Ryding; Robin Weir; Chim Lang; Debashis Roy; Shaumik Adhya; Piers Clifford; Andrew Ludman; Elena Cowan; Paul Kalra; Mary Lynch; Shahid Mahmood; Abdallah Al Mohammad; Joshua Asubiaro; Balgit Chhokar; Patrick Davey; Einas Elmahi; Amal Muthumala; Justin Taylor; Dinesh Gupta; Venkatesh Nadar; David Henderson; Ronald Zolty; Andrew Sauer; Lokesh Chandra; Naseem Jaffrani; Gurinder Grewal; Donna Mancini; Dalton McLean; Javier Vasallo; Amarinder Bindra; Stephen Gottlieb; Susan Joseph; Rajat Barua; Mahazarin Ginwalla; Eiran Gorodeski; Assad Mouhaffel; Eugene Chung; Pratik Desai; Edward Portnay; Bhola Rama; Adrian Shandling; Llyod Stahl; Gregory Thomas; Karl Heilman; Binu Jacob; Juan Londono; Oswaldo Sandoval; Randall Starling; Omar Almousalli; Thomas Ashcom; Eugene Joseph Bauerlein; Sandra Chaparro; Charles Koo; Laurie Letarte; Frank McGrew; Navin Rajagopalan; Shawn Robinson; David Schultz; Mark Zucker; Larry Allen; Amrut Ambardekar; Ravi Bhagwat; John Boehmer; Manuel Bouza; Neil Farris; Scott Feitell; Jagadeesh Ganji; Edward Geltman; Julian Javier; John Andrew Morrow; Leonard Pianko; Frank Smart; Alexander Adler; Douglas Brinkley; Jose Cardona; Andrew Coletti; John Harris; Vernon Hunter; Mori Krantz; Christopher Lang; Daniel Lenihan; Charles Lovell; David Murray; Priya Pillutla; Amit Shah; Carlos Arrieta Garcia; Roberta Bogaev; Ira Dauber; Francesco Franchi; Richard Fremont; Philip Haines; Terence Hart; Brack Hattler; Matthew Janik; Wissam Khalife; Brenda Lemus; Sanjay Malhotra; Shafiq Mamdani; John Murray; William Nelson; Marisa Orgera; Aurelio Ortiz; Peter Rahko; Stephen Rennyson; Fabiana Rollini; Jooyoung Shin; Lana Tsao; Barry Uretsky; Faisal Wahid; Matt Wilkett; Aman Amanullah; Mathue Baker; Martin Berk; Fernando Boccalandro; Kimberly Cruz; Timothy Doyle; Scott Franczek; Lawrence Galitz; Giovanni Geronilla; Robert Gianfagna; Alonzo Jones; Anthony King; Steven Krueger; Norman Lepor; Melvin Martinez-Castrillon; Alan Meholick; Madhusudhan Pamganamamula; Michael Pham; Michael Radin; Joseph Radojevic; Kodangudi Ramanathan; Carsten Schmalfuss; Robert Schnitzler; Keyur Shah; Theodore Takata; Barry Bertolet; Brian Bostick; Andrew Civitello; John Collins; Cristina Danila; Nabil Dib; Stavros Drakos; Richard Gilmore; Wayne Gray; Luanda Grazette; Tariq Haddad; Syed Hasni; Steven Hearne; Munir Janmohamed; Richard Katz; Navid Kazemi; Sara Llerena; Nicole Lohr; George Marzouka; John Mignone; Arunima Misra; Henry Ooi; Gurusher Panjrath; Anna Paszczuk; Christopher Pickett; Joseph Rahman; Gregory Sampognaro; Anays Santana Izquierdo; Douglas Sawyer; Steven Shayani; Inder Singh; Charles Treasure; Garth Vaz; Nampalli Vijay; James Watts; Celeste Williams; Gary Yeoman; Lily Zhang; Keith Aaronson; Wael AboAuda; Rami Alharethi; William Anderson; Mehrdad Ariani; Sourin Banerji; Paramdeep Baweja; Peter Carson; John Corbelli; Arthur Eberly 3rd; James Elliott; Ronald Fernando; Daniel Fisher; Steven Forman; George Gabriel; Harinder Gogia; Craig Hametz; Glenn Hamroff; Brian Houston; Hassan Ibrahim; Farid Jadbabaie; Christos Kassiotis; Arun Krishnamoorthy; Michael Kwan; Steven Lupovitch; Leonardo Macias; Adnan Malik; Douglas Martel; Luis Martinez; Michael Miyamoto; Freny Mody; Vasilios Papademetriou; Devesh Patel; Daniel Pauly; Brenda Peart; Barbara Pisani; Mark Ramos; Mariel Rivero; Anil Shah; Mukesh Sharma; Rajesh Sharma; Tina Sichrovsky; Marc Simon; Deovrat Singh; Mark Smith; Julio Tallet; Christopher Vaccari; Mario Villoch; Bradley Weinberg; Matthew Wheeler; Amin Yehya; Kabir Yousuf; Rafik Abadier; Shuaib Abdullah; Raveen Arora; Shamaila Aslam; Andrew Boyle; Robert Buynak; David Chang; A Alan Chu; Johanna Contreras; Stephen Halpern; Michele Hamilton; Franklin Handel; John Heitner; William Herzog; Bruce Jackson; John Kao; Nicholas Kondo; Michael Koren; Martin LeWinter; Jeffrey Martindale; Joaquin Martinez-Arraras; Stephanie Olsen; Marek Piatek; Nandkishore Ranadive; William Randall; Sunder Rao; David Rawitscher; Gordon Reeves; James Rider; George Sokos; J Russell Strader; Nasir Sulemanjee; Naeem Tahirkheli; Vinay Thohan; Benjamin Trichon; Thomas Vanhecke; David Whellan; Mohammad Abuannadi; Gaurav Aggarwala; Saad Ahmad; Andre Artis; Jorge Cheirif; Jennifer Cook; Vladimir Cotarlan; Jeremy Cox; Charles Eaton; Viorel Florea; Theodore Frank; Keith Friedman; Vedampattu Ganeshram; Alan Gass; Anthony Gemignani; Chester Hedgepeth; Dipti Itchhaporia; Edo Kaluski; Amin Karim; Alan Kono; Ellis Lader; Batlagundu Lakshminarayanan; Neil Lewis; Vinay Malhotra; Nolan Mayer; Robert Mohapatra; Nandini Nair; Terrence O'Brien; Sunil Pauwaa; Florence Rothenberg; Christopher Rowan; Sanjeev Saxena; Arnold Seto; Nishant Shah; Pradeep Singh; Hal Skopicki; Marcus Stoddard; Nancy Sweitzer; Thomas Duythuc To
Contributors:	J. R., Teerlink; R., Diaz; G., Michael Felker; J. J. V., Mcmurray; M., Metra; S. D., Solomon; K. F., Adam; I., Anand; A., Arias-Mendoza; T., Biering-Sorensen; M., Bohm; D., Bonderman; J. G. F., Cleland; R., Corbalan; M. G., Crespo-Leiro; U., Dahlstrom; L. E., Echeverria; J. C., Fang; G., Filippato; C., Fonseca; E., Goncalvesova; A. R., Goudev; J. G., Howlett; D. E., Lanfear; J., Li; M., Lund; P., Macdonald; V., Mareev; S., Momomura; E., O'Meara; A., Parkhomenko; P., Ponikowski; F. J. A., Ramire; P., Serpyti; K., Sliwa; J., Spinar; T. M., Suter; J., Tomcsanyi; H., Vandekerckhove; D., Vinereanu; A. A., Voor; M. B., Yilmaz; F., Zannad; L., Sharpsten; J. C., Legg; C., Varin; N., Honarpour; S. A., Abbasi; F. I., Malik; GALACTIC-HF Investigators: John R Teerlink, Kurtz C. E.; Díaz, Rafael; Santa Fe, Rosario; Michael Felker, G; V McMurray, John J; Metra, Marco; D Solomon, Scott; I Malik, Fady; E Kurtz, Christopher; Abbasi, Siddique; Knusel, Beat; Hucko, Thoma; Groarke, John; Honarpour, Narimon; C Legg, Jason; Sharpsten, Lucie; Varin, Claire; A Konstam, Marvin; Butler, Javed; Dargie, Henry; Massaro, Joseph; H Greenberg, Barry; L Januzzi, Jame; J Lesko, Lawrence; N Upshaw, Jenica; Lopes, Renato; Schuyler Jones, W; P Alexander, Karen; M Al-Khatib, Sana; W Harrison, Robert; Dedrick Jordan, J; F Kong, David; Mathews, Robin; W McGarrah, Robert; H Metha, Rajendra; Melloni, Chiara; J Povsic, Thoma; Shah, Shreyansh; Claggett, Brian; Adams, Kirkwood; Anand, Inder; Arias Mendoza, Alexandra; Biering-Sørensen, Tor; Böhm, Michael; Bonderman, Diana; Cleland, John; Corbalan Herreros, Ramon; Crespo Leiro, Marisa; Dahlstrom, Ulf; Diaz, Rafael; Eduardo Echeverria, Lui
Publication Year:	2021
Collection:	IRIS UNIPV (Università degli studi di Pavia)
Subject Terms:	Aged; 80 and over; Cardiac Myosin; Cardiotonic Agent; Cardiovascular Disease; Female; Heart Failure; Systolic; Human; Male; Middle Aged; Myocardial Contraction; Stroke Volume; Urea
Description:	BACKGROUND The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. METHODS We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes. RESULTS During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P = 0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro-B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups. CONCLUSIONS Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, NCT02929329; EudraCT number, 2016 -002299-28.).
Document Type:	article in journal/newspaper
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/33185990; info:eu-repo/semantics/altIdentifier/wos/WOS:000609886200010; volume:384; issue:2; firstpage:105; lastpage:116; numberofpages:12; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/11571/1438756
DOI:	10.1056/NEJMoa2025797
Availability:	http://hdl.handle.net/11571/1438756; https://doi.org/10.1056/NEJMoa2025797
Accession Number:	edsbas.310D1DF5
Database:	BASE