| Title: |
The overlapping burden of the three leading causes of disability and death in sub-Saharan African children |
| Authors: |
Reiner, RC; Welgan, CA; Troeger, CE; Baumann, MM; Weiss, DJ; Deshpande, A; Blacker, BF; Miller Petrie, MK; Earl, L; Bhatt, S; Abolhassani, H; Abosetugn, AE; Abu Gharbieh, E; Adekanmbi, V; Adetokunboh, OO; Aghaali, M; Aji, B; Alahdab, F; Al Aly, Z; Alhassan, RK; Ali, S; Alizade, H; Aljunid, SM; Almasi Hashiani, A; Al Mekhlafi, HM; Altirkawi, KA; Alvis Guzman, N; Amare, AT; Amini, S; Amugsi, DA; Ancuceanu, R; Andrei, CL; Ansari, F; Anvari, D; Appiah, SCY; Arabloo, J; Aremu, O; Atout, MMW; Ausloos, M; Ausloos, F; Ayanore, MA; Aynalem, YA; Azene, ZN; Badawi, A; Baig, AA; Banach, M; Bedi, N; Bhagavathula, AS; Bhandari, D; Bhardwaj, N; Bhardwaj, P; Bhattacharyya, K; Bhutta, ZA; Bijani, A; Birhanu, TTM; Bitew, ZW; Boloor, A; Brady, OJ; Butt, ZA; Car, J; Carvalho, F; Casey, DC; Chattu, VK; Chowdhury, MAK; Chu, D; Coelho, CH; Cook, AJ; Damiani, G; Daoud, F; Gela, JD; Darwish, AH; Daryani, A; Das, JK; Davis Weaver, N; Deribe, K; Desalew, A; Dharmaratne, SD; Dianatinasab, M; Diaz, D; Djalalinia, S; Dorostkar, F; Dubljanin, E; Duko, B; Dwyer Lindgren, L; Effiong, A; El Sayed Zaki, M; El Tantawi, M; Enany, S; Fattahi, N; Feigin, VL; Fernandes, E; Ferrara, P; Fischer, F; Foigt, NA; Folayan, MO; Foroutan, M; Frostad, JJ; Fukumoto, T; Gaidhane, AM; Gebrekrstos, HGGK; Gebremeskel, L; Gebreslassie, AA; Gething, PW; Gezae, KE; Ghadiri, K; Ghashghaee, A; Golechha, M; Gubari, MIM; Hadgu, FB; Hamidi, S; Handiso, DW; Hashi, A; Hassan, S; Hayat, K; Herteliu, C; Ho, HC; Holla, R; Hosseinzadeh, M; Househ, M; Hussain, R; Hwang, B; Ibitoye, SE; Ilesanmi, OS; Ilic, IM; Ilic, MD; Irvani, SSN; Jaafari, J; Javaheri, T; Jha, RP; Johnson, KB; Jonas, JB; Jozwiak, JJ; Kabir, A; Kalhor, R; Kanchan, T; Karch, A; Kayode, GA; Keiyoro, PN; Khader, YS; Khalil, IA; Khan, MN; Khan, M; Khan, G; Khatab, K; Khater, MM; Khatib, MN; Kianipour, N; Kim, YJ; Kimokoti, RW; Kisa, S; Kisa, A; Kissoon, N; Kochhar, S; Koolivand, A; Kopec, JA; Koyanagi, A; Krishan, K; Kumar, P; Kurmi, OP; Kusuma, D; Lal, DK; Lami, FH; Landires, I; Lansingh, VC; Lasrado, S; La Vecchia, C; Lazzar Atwood, A; Lee, PH; LeGrand, KE; Lewycka, S; Li, B; Lim, SS; Lindstedt, PA; Liu, X; Longbottom, J; Lopez, AD; Magdy Abd El Razek, H; Mahasha, PW; Maleki, A; Mamun, AA; Mansournia, MA; Marczak, LB; Martins Melo, FR; Mayala, BK; Meharie, BG; Melese, A; Mendoza, W; Menezes, RG; Mengesha, EW; Mensah, GA; Meretoja, TJ; Mestrovic, T; Miller, TR; Mirrakhimov, EM; Moazen, B; Mohammad Gholi Mezerji, N; Mohammadi, S; Mohammed, S; Mokdad, AH; Moradi, M; Moradzadeh, R; Moraga, P; Mosser, JF; Murray, CJL; Naderi, M; Nagarajan, AJ; Nazari, J; Ndejjo, R; Negoi, I; Ngunjiri, JW; Nguyen, QP; Nguyen, HLT; Nnaji, CA; Noubiap, JJ; Nuñez Samudio, V; Olagunju, AT; Olusanya, JO; Olusanya, BO; Omer, MO; Onwujekwe, OE; Otstavnov, N; Otstavnov, SS; Owolabi, MO; P A, M; Padubidri, JR; Pana, A; Peprah, EK; Pham, HQ; Pigott, DM; Pirestani, M; Postma, MJ; Pottoo, FH; Pourjafar, H; Quazi Syed, Z; Rahim, F; Rahimi Movaghar, V; Rahman, MHU; Rao, SJ; Rao, PC; Rathi, P; Rawaf, S; Rawaf, DL; Rawal, L; Rawassizadeh, R; Regassa, LD; Renzaho, AMN; Rezaei, N; Rezai, MS; Ribeiro, AI; Rickard, J; Rios González, CM; Rumisha, SF; Sabour, S; Sajadi, SM; Salomon, JA; Samadi Kafil, H; Samy, AM; Sanabria, J; Sartorius, B; Saxena, D; Schaeffer, LE; Senthilkumaran, S; Sha, F; Shaheen, AA; Shaikh, MA; Sharma, R; Sheikh, A; Shibuya, K; Shigematsu, M; Il Shin, J; Simonetti, B; Singh, JA; Smith, DL; Soheili, A; Sokhan, A; Spurlock, EE; Sreeramareddy, CT; Sufiyan, MB; Swartz, SJ; Tadesse, DB; Tamiru, AT; Tefera, YG; Temsah, M; Tessema, ZT; Titova, MV; Tran, BX; Truong, PN; Unnikrishnan, B; Upadhyay, E; Vasankari, TJ; Vasseghian, Y; Violante, FS; Vu, GT; Waheed, Y; Wamai, RG; Wassie, EG; Welay, FT; Wickramasinghe, ND; Wiens, KE; Wijeratne, T; Wiysonge, CS; Wondmeneh, TG; Yamada, T; Yaya, S; Yeshitila, YG; Yip, P; Yonemoto, N; Yu, C; Yuce, D; Yusefzadeh, H; Zaidi, Z; Zamanian, M; Zangeneh, A; Zhang, Z; Zhang, Y; Ziapour, A; Hay, SI |
| Contributors: |
Instituto de Saúde Pública da Universidade do Porto |
| Publisher Information: |
Nature Research |
| Publication Year: |
2022 |
| Collection: |
Repositório Aberto da Universidade do Porto |
| Description: |
Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival. © 2022, The Author(s). ; Funding text 1: This work was primarily supported by grant OPP1132415 from the Bill & Melinda Gates Foundation. ; Funding text 2: This study was funded by the Bill & Melinda Gates Foundation. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. The non-consortium authors have no competing interests . Competing interests for consortium authors is as follows: Robert Ancuceanu reports receiving consultancy or speaker feeds from UCB, Sandoz, Abbvie, Zentiva, Teva, Laropharm, CEGEDIM, Angelini, Biessen Pharma, Hofigal, AstraZeneca, and Stada. Jacek Jerzy Jozwiak reports personal fees from Amgen, ALAB Laboratories, Teva, Synexus, Boehringer Ingelheim, and Zentiva, all outside the submitted work. Kewal Krishan reports non-financial support from UGC Centre of Advanced Study, CAS II, ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://www.nature.com/articles/s41467-022-34240-6; https://hdl.handle.net/10216/151495 |
| DOI: |
10.1038/s41467-022-34240-6 |
| Availability: |
https://hdl.handle.net/10216/151495; https://doi.org/10.1038/s41467-022-34240-6 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.31205F80 |
| Database: |
BASE |