| Title: |
Clinical Effect of Early vs Late Amyloid Positron Emission Tomography in Memory Clinic Patients |
| Authors: |
Altomare, Daniele; Barkhof, Frederik; Caprioglio, Camilla; Collij, Lyduine; Scheltens, Philip; Lopes Alves, Isadora; Bouwman, Femke; Berkhof, Johannes; van Maurik, Ingrid; Garibotto, Valentina; Moro, Christian; Delrieu, Julien; Payoux, Pierre; Saint-Aubert, Laure; Hitzel, Anne; Molinuevo, José Luis; Grau-Rivera, Oriol; Gispert, Juan Domingo; Drzezga, Alexander; Jessen, Frank; Zeyen, Philip; Nordberg, Agneta; Savitcheva, Irina; Jelic, Vesna; Walker, Zuzana; Edison, Paul; Demonet, Jean-François; Gismondi, Rossella; Farrar, Gill; Stephens, Andrew; Frisoni, Giovanni; Abdelnour, Carla; Aguilera, Nuria; Aksman, Leon; Alarcón-Martín, Emilio; Alegret, Montse; Alonso-Lana, Silvia; Andersen, Pia; Arab, Majd; Aspö, Malin; Bader, Ilona; Bader, Ilse; Banton, Nigel; Barnes, Rodrigo; Barrie, Dawn; Battle, Mark; Belén Collado, Ana; Bellet, Julie; Biger, Marine; Birck, Cindy; Bischof, Gerard; Boada, Mercè; Boellaard, Ronald; Bogdanovic, Nenad; Bollack, Ariane; Bombois, Stéphanie; Borg, Stefan; Borjesson-Hanson, Anne; Boskov, Vladimir; Boutantin, Justine; Boutoleau-Bretonniere, Claire; Breuilh, Laetitia; Bringman, Eva; Brunel, Baptiste; Bucci, Marco; Buckley, Chris; Buendía, Mar; Bullich, Santi; Calvet, Anna; Cañada, Laia; Cañada, Marta; Cardoso, Jorge; Carlier, Jasmine; Carre, Elise; Carrie, Isabelle; Cassagnaud, Pascaline; Cassol, Emmanuelle; Castilla-Martí, Miguel; Cazalon, Elodie; Chaarriau, Tiphaine; Chaigeau, Rachel; Chalmers, Taylor; Clerc, Marie-Thérèse; Clerigue, Montserrat; Cognat, Emmanuel; Coll, Nina; Connely, Peter; Cordier, Elodie; Costes, Corine; Coulange, Camille; Courtemanche, Hélène; Creisson, Eric; Crinquette, Charlotte; Cuevas, Rosario; Cufi, Marie-Noëlle; Dardenne, Sophie; de Arriba, Maria; de Costa Luis, Casper; de Gier, Yvonne; de Verbizier Lonjon, Delphine; Dekker, Veronique; Dekyndt, Bérengère; Delbeuck, Xavier; Deramecourt, Vincent; Desclaux, Françoise; Diaz, Carlos; Diego, Susana; Djafar, Mehdi; Dölle, Britta; Doull, Laura; Dricot, Laurence; Dubois, Bruno; Dumont, Julien; Dumur, Jean; Dumurgier, Julien; Dvorak, Martin; Ecay, Mirian; Escher, Claus; Estanga, Ainara; Esteban, Ester; Fanjaud, Guy; Fauria, Karine; Felez Sanchez, Marta; Feukam Talla, Patrick; Ford, Lisa; Fuster, David; Gabelle, Audrey; Gaubert, Sinead; Gauci, Cédric; Geldhof, Christine; Georges, Jean; Ghika, Joseph; González, Elena; Goovaerts, Valerie; Goulart, Denis Mariano; Grasselli, Caroline; Gray, Katherine; Greensmith, Martin; Grozn, Laure; Guillemaud, Céline; Gunn, Fiona; Guntur Ramkumar, Prasad; Hagman, Göran; Hansseuw, Bernard; Heeman, Fiona; Hendriks, Janine; Himmelmann, Jakob; Hives, Florent; Hoenig, Merle; Hourrègue, Claire; Hudson, Justine; Huguet, Jordi; Ibarria, Marta; Iidow, Ifrah; Indart, Sandrine; Ingala, Silvia; Ivanoiu, Adrian; Jacquemont, Charlotte; Jiao, Jieqing; Jofresa, Sara; Jonsson, Cathrine; Kaliukhovich, Dzmitry; Kern, Silke; Kivipelto, Miia; Knezevic, Iva; Kuchcinski, Grégory; Laforce, Manon; Lafuente, Asunción; Lala, Françoise; Lammertsma, Adriaan; Lax, Michelle; Lebouvier, Thibaud; Lee, Ho-Yun; Lee, Lean; Leeuwis, Annebet; Lefort, Amandine; Legrand, Jean-François; Leroy, Mélanie; Lesoil Markowski, Constance; Levy, Marcel; Lhommel, Renaud; Lopes, Renaud; Lorenzini, Luigi; Lorette, Adrien; Luckett, Emma; Lundin, Marie; Mackowiak, Marie-Anne; Malotaux, Vincent; Manber, Richard; Manyakov, Nikolay; Markiewicz, Pawel; Marne, Paula; Marquié, Marta; Martín, Elvira; Martínez, Joan; Martinez Lage, Pablo; Mastenbroek, Sophie; Maureille, Aurélien; Meersmans, Karen; Mett, Anja; Milne, Joseph; Minguillón, Carolina; Modat, Marc; Montrreal, Laura; Müller, Theresa; Muniz, Graciela; Mutsarts, Henk Jan; Nilsson, Ted; Ninerola, Aida; Novaes, Wilse; Nuno Carmelo Pires Silva, Joao; Operto, Greg; Orellana, Adela; Ousset, Pierre-Jean; Outteryck, Olivier; Pallardy, Amandine; Palombit, Alessandro; Pancho, Ana; Pappon, Martin; Paquet, Claire; Pariente, Jérémie; Pasquier, Florence; Peaker, Harry; Pelejà, Esther; Pennetier, Delphine; Pérez-Cordón, Alba; Perissinotti, Andrés; Perrenoud, Matthieu Paul; Petit, Sandrine; Petyt, Grégory; Pfeil, Julia; Pirotte, Blanche; Pla, Sandra; Plaza Wuthrich, Sonia; Poitrine, Lea; Pollet, Marianne; Poncelet, Jean-Benoit; Prior, John; Pruvo, Jean-Pierre; Putallaz, Pauline; Queneau, Mathieu; Quenon, Lisa; Rădoi, Andreea; Rafiq, Marie; Ramage, Fiona; Ramis, Maribel; Reinwald, Michael; Rios, Gonzalo; Ritchie, Craig; Rodriguez, Elena; Rollin, Adeline; Rouaud, Olivier; Sacuiu, Simona; Sala, Arianna; Salabert, Anne-Sophie; Saldias, Jon; Salvadó, Gemma; Sanabria, Angela; Sannemann, Lena; Sastre, Nathalie; Savina, Daniela; Schaeverbeke, Jolien; Schildermans, Carine; Schmidt, Mark; Schöll, Michael; Schuermans, Jeroen; Semah, Franck; Shekari, Mahnaz; Skoog, Ingmar; Sotolongo-Grau, Oscar; Stewart, Tiffany; Stutzmann, Jennyfer; Tait, Murray; Tárraga, Lluis; Tartari, Juan Pablo; Tysen-Backstrom, Ann-Christine; Valero, Sergi; Vallez Garcia, David; van Berckel, Bart N.M.; van Essen, Martijn; van Laere, Koen; van Leur, Jeroen; Vandenberghe, Rik; Vellas, Bruno; Virolinen, Jukka; Visser, Pieter Jelle; Walles, Håkan; Wallin, Emilia; Whitelaw, Grant; Wimberley, Catriona; Win, Zarni; Wink, Alle Meije; Wolz, Robin; Woodside, John; Yaqub, Maqsood; Zettergren, Anna |
| Contributors: |
Laboratory of Neuroimaging of aging, Memory clinic and LANVIE; Geneva University Hospital and Geneva University; Università degli Studi di Brescia = University of Brescia (UniBs); Geneva University Hospitals and Geneva University; Amsterdam University Medical Centers (Amsterdam UMC); Pôle Gériatrie CHU Toulouse; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Equipe AGING (CERPOP); Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP); Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM); Toulouse NeuroImaging Center (ToNIC); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI); Université Toulouse - Jean Jaurès (UT2J); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Université Toulouse - Jean Jaurès (UT2J); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse); Service de Médecine Nucléaire - Rangueil CHU Toulouse; Pôle imagerie médicale CHU Toulouse; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Barcelonaβeta Brain Research Center (BBRC); Pasqual Maragall Foundation; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH); IMIM-Hospital del Mar; Generalitat de Catalunya = Generalidad de Cataluña = Government of Catalonia = Généralité de Catalogne; Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES); Centro Investigacion Biomedica en Red Bioingenieria, Biomateriales y Nanomedicina - CIBER-BBN (SPAIN); University Hospital of Cologne Cologne; Laboratoire de Psychologie des Pays de la Loire (LPPL); Université d'Angers (UA)-Nantes Université - UFR Lettres et Langages (Nantes Univ - UFR LL); Nantes Université - pôle Humanités; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Humanités; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ) |
| Source: |
ISSN: 2168-6149. |
| Publisher Information: |
CCSD; American Medical Association |
| Publication Year: |
2023 |
| Collection: |
Université Toulouse III - Paul Sabatier: HAL-UPS |
| Subject Terms: |
MESH: Aged; MESH: Alzheimer Disease / psychology; MESH: Positron-Emission Tomography; MESH: Prospective Studies; MESH: Amyloid / metabolism; MESH: Amyloid beta-Peptides / metabolism; MESH: Amyloidogenic Proteins; MESH: Brain / metabolism; MESH: Cognitive Dysfunction; MESH: Female; MESH: Humans; MESH: Male; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Importance Amyloid positron emission tomography (PET) allows the direct assessment of amyloid deposition, one of the main hallmarks of Alzheimer disease. However, this technique is currently not widely reimbursed because of the lack of appropriately designed studies demonstrating its clinical effect. Objective To assess the clinical effect of amyloid PET in memory clinic patients. Design, Setting, and Participants The AMYPAD-DPMS is a prospective randomized clinical trial in 8 European memory clinics. Participants were allocated (using a minimization method) to 3 study groups based on the performance of amyloid PET: arm 1, early in the diagnostic workup (within 1 month); arm 2, late in the diagnostic workup (after a mean [SD] 8 [2] months); or arm 3, if and when the managing physician chose. Participants were patients with subjective cognitive decline plus (SCD+; SCD plus clinical features increasing the likelihood of preclinical Alzheimer disease), mild cognitive impairment (MCI), or dementia; they were assessed at baseline and after 3 months. Recruitment took place between April 16, 2018, and October 30, 2020. Data analysis was performed from July 2022 to January 2023. Intervention Amyloid PET. Main Outcome and Measure The main outcome was the difference between arm 1 and arm 2 in the proportion of participants receiving an etiological diagnosis with a very high confidence (ie, ≥90% on a 50%-100% visual numeric scale) after 3 months. Results A total of 844 participants were screened, and 840 were enrolled (291 in arm 1, 271 in arm 2, 278 in arm 3). Baseline and 3-month visit data were available for 272 participants in arm 1 and 260 in arm 2 (median [IQR] age: 71 [65-77] and 71 [65-77] years; 150/272 male [55%] and 135/260 male [52%]; 122/272 female [45%] and 125/260 female [48%]; median [IQR] education: 12 [10-15] and 13 [10-16] years, respectively). After 3 months, 109 of 272 participants (40%) in arm 1 had a diagnosis with very high confidence vs 30 of 260 (11%) in arm 2 ( P < ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/37155177; PUBMED: 37155177; PUBMEDCENTRAL: PMC10167601 |
| DOI: |
10.1001/jamaneurol.2023.0997 |
| Availability: |
https://hal.science/hal-04702532; https://hal.science/hal-04702532v1/document; https://hal.science/hal-04702532v1/file/Altomare_2023.pdf; https://doi.org/10.1001/jamaneurol.2023.0997 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.313147FB |
| Database: |
BASE |