| Title: |
Dicarboxylic acids as pH sensors for hyperpolarized 13 C magnetic resonance spectroscopic imaging |
| Authors: |
Korenchan, DE; Taglang, C; von Morze, C; Blecha, JE; Gordon, JW; Sriram, R; Larson, PEZ; Vigneron, DB; VanBrocklin, HF; Kurhanewicz, J; Wilson, DM; Flavell, RR |
| Source: |
Analyst, vol 142, iss 9 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2017 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
3402 Inorganic Chemistry (for-2020); 34 Chemical Sciences (for-2020); Bioengineering (rcdc); Biomedical Imaging (rcdc); Carbon Isotopes (mesh); Dicarboxylic Acids (mesh); Hydrogen-Ion Concentration (mesh); Magnetic Resonance Imaging (mesh); Magnetic Resonance Spectroscopy (mesh); Phantoms; Imaging (mesh); 0301 Analytical Chemistry (for); 0399 Other Chemical Sciences (for); Analytical Chemistry (science-metrix); 3401 Analytical chemistry (for-2020) |
| Time: |
1429 - 1433 |
| Description: |
Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent 13C chemical shift over the physiological range. We demonstrate that co-polarization with [1-13C,D9]tert-butanol accurately measures pH via13C NMR and magnetic resonance spectroscopic imaging in phantoms. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt1hc2h13n; https://escholarship.org/uc/item/1hc2h13n; https://escholarship.org/content/qt1hc2h13n/qt1hc2h13n.pdf |
| DOI: |
10.1039/c7an00076f |
| Availability: |
https://escholarship.org/uc/item/1hc2h13n; https://escholarship.org/content/qt1hc2h13n/qt1hc2h13n.pdf; https://doi.org/10.1039/c7an00076f |
| Rights: |
public |
| Accession Number: |
edsbas.313D8B4 |
| Database: |
BASE |