| Title: |
Altered plasma protein profiles in genetic FTD – a GENFI study |
| Authors: |
Ullgren, A; Öijerstedt, L; Olofsson, J; Bergström, S; Remnestål, J; van Swieten, JC; Jiskoot, LC; Seelaar, H; Borroni, B; Sanchez-Valle, R; Moreno, F; Thonberg, H; Sogorb-Esteve, A; Timberlake, C; Todd, E; Santana, I; Van Damme, P; Vandenbulcke, M; Veldsman, M; Galimberti, D; Verdelho, A; Anderl-Straub, S; Villanua, J; Warren, J; Convery, R; Wilke, C; Woollacott, I; Zetterberg, H; Ducharme, S; Zulaica, M; Durães, J; Lima, M; Fumagalli, G; Lemos, J; Rowe, JB; Masellis, M; Heller, C; Tartaglia, MC; Finger, E; Vandenberghe, R; de Mendonça, A; Butler, CR; Gerhard, A; Andersson, C; Otto, M; Bouzigues, A; Russell, L; Swift, IJ; Rohrer, JD; Månberg, A; Nilsson, P; Graff, C; Afonso, S; Almeida, MR; Antonell, A; Cope, T; Arighi, A; Balasa, M; Barandiaran, M; Bargalló, N; Bartha, R; Greaves, C; Bender, B; Buratti, E; Peakman, G; Benussi, L; Bertoux, M; Binetti, G; Deramecourt, V; Black, S; Bocchetta, M; Borrego-Ecija, S; Rogaeva, E; Bras, J; Bruffaerts, R; Cañada, M; Funkiewiez, A; Cantoni, V; Caroppo, P; Cash, D; Castelo-Branco, M; Di Fede, G; Díez, A; Guerreiro, R; Fenoglio, C; Ferreira, CB; Fox, N; Freedman, M; Gabilondo, A; Gasparotti, R; Gauthier, S; Alberici, A; Giaccone, G; Gorostidi, A; Indakoetxea, B; Pievani, M; Jelic, V; Karnath, H-O; Keren, R; Kuchcinski, G; Langheinrich, T; Shoesmith, C; Lebouvier, T; Leitão, MJ; Laforce, R; Lladó, A; Maruta, C; Meeter, L; Pijnenburg, Y; Miltenberger, G; van Minkelen, R; Mitchell, S; Tirabosch, P; Moore, K; Nicholas, J; Olives, J; Rollin, A; Ourselin, S; Padovani, A; Panman, J; Papma, JM; Premi, E; Prioni, S; Tábuas-Pereira, M; Rademakers, R; Redaelli, V; Rinaldi, D; Rittman, T; Rosa-Neto, P; Rossi, G; Rosser, M; Scarpini, E; Semler, E; Shafei, R; Tainta, M; Synofzik, M; Taipa, R; Tang-Wai, D; Thomas, DL; Thompson, P |
| Contributors: |
Genetic Frontotemporal Dementia Initiative (GENFI) |
| Publisher Information: |
BioMed Central (part of Springer Nature) |
| Publication Year: |
2023 |
| Collection: |
Brunel University London: Brunel University Research Archive (BURA) |
| Subject Terms: |
frontotemporal dementia; plasma biomarkers; GRN; C9orf72; MAPT; neurodegeneration |
| Description: |
Availability of data and materials: Anonymized data may be shared upon request from a qualified academic investigator for the purpose of replication of the results and procedures detailed in this article. All requests must be in agreement with EU legislation on general data protection and must be in line with the decisions from the Ethical Review Board of Sweden. Data sharing should be regulated in a material transfer agreement and/or data processing agreement as appropriate. ; Supplementary Information is available online at: https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00677-6#Sec16 . ; Copyright © The Author(s) 2023. Background: Plasma biomarkers reflecting the pathology of frontotemporal dementia would add significant value to clinical practice, to the design and implementation of treatment trials as well as our understanding of disease mechanisms. The aim of this study was to explore the levels of multiple plasma proteins in individuals from families with genetic frontotemporal dementia. Methods: Blood samples from 693 participants in the GENetic Frontotemporal Dementia Initiative study were analysed using a multiplexed antibody array targeting 158 proteins. Results: We found 13 elevated proteins in symptomatic mutation carriers, when comparing plasma levels from people diagnosed with genetic FTD to healthy non-mutation controls and 10 proteins that were elevated compared to presymptomatic mutation carriers. Conclusion: We identified plasma proteins with altered levels in symptomatic mutation carriers compared to non-carrier controls as well as to presymptomatic mutation carriers. Further investigations are needed to elucidate their potential as fluid biomarkers of the disease process. ; Open access funding provided by Karolinska Institute. C.G. received funding from EU Joint Programme—Neurodegenerative Disease Research -Prefrontals Vetenskapsrådet Dnr 529–2014-7504, Vetenskapsrådet 2015–02926, Vetenskapsrådet 2018–02754, the Swedish FTD Inititative-Schörling Foundation, ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
1 - 12; Electronic |
| Language: |
English |
| Relation: |
Molecular Neurodegeneration; 85; https://bura.brunel.ac.uk/handle/2438/27687 |
| DOI: |
10.1186/s13024-023-00677-6 |
| Availability: |
https://bura.brunel.ac.uk/handle/2438/27687; https://doi.org/10.1186/s13024-023-00677-6 |
| Rights: |
Copyright © The Author(s) 2023. Rights and permissions: Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. ; https://creativecommons.org/licenses/by/4.0/ ; The Author(s) |
| Accession Number: |
edsbas.31BA04BB |
| Database: |
BASE |