| Title: |
Endometriosis recurrence following post-operative hormonal suppression: a systematic review and meta-analysis |
| Authors: |
Zakhari, Andrew; Delpero, Emily; McKeown, Sandra; Tomlinson, George; Bougie, Olga; Murji, Ally |
| Contributors: |
Mount Sinai Hospital; epartment of Obstetrics & Gynaecology Generalist Practice Plan and the Comprehensive Research Experience for Medical Students; University of Toronto |
| Source: |
Human Reproduction Update ; volume 27, issue 1, page 96-107 ; ISSN 1355-4786 1460-2369 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2020 |
| Description: |
BACKGROUND Although surgery for endometriosis can improve pain and fertility, the risk of disease recurrence is high. There is little consensus regarding the benefit of medical therapy in preventing recurrence of endometriosis following surgery. OBJECTIVE AND RATIONALE We performed a review of prospective observational studies and randomised controlled trials (RCTs) to evaluate the risk of endometriosis recurrence in patients undergoing post-operative hormonal suppression, compared to placebo/expectant management. SEARCH METHODS The following databases were searched from inception to March 2020 for RCTs and prospective observational cohort studies: MEDLINE, Embase, Cochrane CENTRAL and Web of Science. We included English language full-text articles of pre-menopausal women undergoing conservative surgery (conserving at least one ovary) and initiating hormonal suppression within 6 weeks post-operatively with either combined hormonal contraceptives (CHC), progestins, androgens, levonorgesterel-releasing intra-uterine system (LNG-IUS) or GnRH agonist or antagonist. We excluded from the final analysis studies with |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/humupd/dmaa033 |
| Availability: |
https://doi.org/10.1093/humupd/dmaa033; http://academic.oup.com/humupd/article-pdf/27/1/96/35387744/dmaa033.pdf |
| Rights: |
http://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.31CDCD7A |
| Database: |
BASE |