| Title: |
Maintenance of cell polarization at the mating projection tip via mechanical feedback. |
| Authors: |
Samhita P. Banavar (4778580); Michael Trogdon (4778586); Brian Drawert (437505); Tau-Mu Yi (257804); Linda R. Petzold (7435412); Otger Campàs (4778583) |
| Publication Year: |
2021 |
| Collection: |
Smithsonian Institution: Digital Repository |
| Subject Terms: |
Biophysics; Microbiology; Cell Biology; Genetics; Molecular Biology; Physiology; Evolutionary Biology; Developmental Biology; Cancer; Hematology; Infectious Diseases; Computational Biology; Biological Sciences not elsewhere classified; Physical Sciences not elsewhere classified; Coordinating cell polarization; Cell Wall Integrity pathway; projection tip; cell changes shape; cell shape; cell polarization; coarse-grained continuum description; morphogenesi; mating projection growth; yeast mating projection growth |
| Description: |
A , A cell initially polarized at the tip, as indicated by the distribution of Cdc42, loses polarization in the absence of mechanical feedback. The cell shape does not change over the short timescale of depolarization. B , An initially depolarized cell (uniform and low Cdc42 concentration) polarizes and grows steadily in the presence of mechanical feedback. C , Polarized or depolarized cell states for varying values of the mechanical feedback strength. Small feedback strengths lead to depolarized solutions (loss of Cdc42 localization at the tip). For feedback strengths above a threshold, cell polarization is stably maintained at the tip during cell growth (Polarized stable solution). The black outlined point denotes the stable solution seen in B and D-G. D-G , Steady state spatial profiles for cell wall expansion rate ( D ), active Bni1 density ( E ), Cdc42 density ( F ) and cell wall thickness h ( G ). |
| Document Type: |
still image |
| Language: |
unknown |
| Relation: |
https://figshare.com/articles/figure/Maintenance_of_cell_polarization_at_the_mating_projection_tip_via_mechanical_feedback_/13660716 |
| DOI: |
10.1371/journal.pcbi.1007971.g002 |
| Availability: |
https://doi.org/10.1371/journal.pcbi.1007971.g002 |
| Rights: |
CC BY 4.0 |
| Accession Number: |
edsbas.31D60C97 |
| Database: |
BASE |