| Title: |
Electron scattering from 1-Methyl-5-Nitroimidazole: cross-sections for modeling electron transport through potential radiosensitizers |
| Authors: |
Lozano, Ana I.; Alvarez, Lidia; Garcia Abenza, Adrian; Guerra, Carlos; Kossoski, Fabris; Rosado Vélez, Jaime; Blanco Ramos, Francisco; Oller, Juan Carlos; Hasan, Mahmudul; Centurion, Martin; Weber, Thorsten; Slaughter, Daniel S.; Mootheril, Deepthy M.; Dorn, Alexander; Kumar, Sarvesh; Limao Vieira, Paulo); Colmenares, Rafael; Garcia, Gustavo |
| Publisher Information: |
MDPI |
| Publication Year: |
2023 |
| Collection: |
Universidad Complutense de Madrid (UCM): E-Prints Complutense |
| Subject Terms: |
539.1; Electron scattering cross-sections; Electron impact molecular fragmentation; Molecular radiosensitizers; Radiation damage; Ionization; Dissociation; Física (Física); Física nuclear; 22 Física; 2207 Física Atómica y Nuclear |
| Description: |
DE-AC02-05CH11231 DESC0019482 UIDB/00068/2020 PTDC/FIS-AQM/31281/2017 CA18212 EURAMET 21GRD02BIOSPHERE ; In this study, we present a complete set of electron scattering cross-sections from 1-Methyl-5-Nitroimidazole (1M5NI) molecules for impact energies ranging from 0.1 to 1000 eV. This information is relevant to evaluate the potential role of 1M5NI as a molecular radiosensitizers. The total electron scattering cross-sections (TCS) that we previously measured with a magnetically confined electron transmission apparatus were considered as the reference values for the present analysis. Elastic scattering cross-sections were calculated by means of two different schemes: The Schwinger multichannel (SMC) method for the lower energies (below 15 eV) and the independent atom model-based screening-corrected additivity rule with interferences (IAM-SCARI) for higher energies (above 15 eV). The latter was also applied to calculate the total ionization cross-sections, which were complemented with experimental values of the induced cationic fragmentation by electron impact. Double differential ionization cross-sections were measured with a reaction microscope multi-particle coincidence spectrometer. Using a momentum imaging spectrometer, direct measurements of the anion fragment yields and kinetic energies by the dissociative electron attachment are also presented. Cross-sections for the other inelastic channels were derived with a self-consistent procedure by sampling their values at a given energy to ensure that the sum of the cross-sections of all the scattering processes available at that energy coincides with the corresponding TCS. This cross-section data set is ready to be used for modelling electron-induced radiation damage at the molecular level to biologically relevant media containing 1M5NI as a potential radiosensitizer. Nonetheless, a proper evaluation of its radiosensitizing effects would require further radiobiological experiments. ; Ministerio de Ciencia e Innovación (España) ; Agencia Estatal de Investigación ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104727RB-C21/ES/EFECTO RADIOBIOLOGICO DE RADICALES Y RADIOSENSIBILIZADOES MOLECULARES (EXPERIMENTOS Y MODELOS)/; info:eu-repo/grantAgreement/MU//PRX21/00340; Lozano, A.I.; Álvarez, L.; García-Abenza, A.; Guerra, C.; Kossoski, F.; Rosado, J.; Blanco, F.; Oller, J.C.; Hasan, M.; Centurion, M.; et al. Electron Scattering from 1-Methyl-5-Nitroimidazole: Cross-Sections for Modeling Electron Transport through Potential Radiosensitizers. Int. J. Mol. Sci. 2023, 24, 12182. https://doi.org/10.3390/ijms241512182; https://hdl.handle.net/20.500.14352/113819 |
| DOI: |
10.3390/ijms241512182 |
| Availability: |
https://hdl.handle.net/20.500.14352/113819; https://doi.org/10.3390/ijms241512182 |
| Rights: |
Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; open access |
| Accession Number: |
edsbas.31DA5655 |
| Database: |
BASE |