| Title: |
Renal Allograft Calcification – Prevalence and Etiology in Pediatric Patients |
| Authors: |
Habbig, Sandra; Beck, Bodo B.; Feldkötter, Markus; Körber, Friederike; Laffeber, Charlie; Verkoelen, Carl; Mihatsch, Michael J.; Hoppe, Bernd |
| Source: |
American Journal of Nephrology ; volume 30, issue 3, page 194-200 ; ISSN 0250-8095 1421-9670 |
| Publisher Information: |
S. Karger AG |
| Publication Year: |
2009 |
| Description: |
Background: Calcification of renal allografts has been reported in adult kidney transplant (KTx) recipients with a widely differing prevalence (2–60%). Persistent hyperparathyroidism, hypercalcemia and concomitant hypercalciuria were identified as major risk factors. We aimed to determine the prevalence and risk factors for such calcifications in children. Methods: We investigated histological stains of routine graft biopsies from pediatric KTx patients for renal calcifications and determined the urinary excretion of lithogenic (oxalate, calcium) and stone-inhibitory substances (citrate). Results: In our series of transplant patients, tubular calcification was found in 16 of the 36 (44.4%) KTx biopsies by an additional Kossa stain. This transplant calcification was not associated with any singular risk factor and was not correlated to a worse transplant outcome. Conclusion: Although our pediatric findings confirm the reported incidence rates of KTx calcification in adults, we could neither identify hypercalciuria as a risk factor nor confirm any negative influence on graft function. However, long-term studies are clearly needed to prove or disprove a negative impact of calcifications on graft function. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1159/000217585 |
| Availability: |
https://doi.org/10.1159/000217585; https://www.karger.com/Article/Pdf/217585 |
| Rights: |
https://www.karger.com/Services/SiteLicenses ; https://www.karger.com/Services/SiteLicenses |
| Accession Number: |
edsbas.32087503 |
| Database: |
BASE |