Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition
| Title: | Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition |
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| Authors: | Bucci, P.; Galderisi, S.; Mucci, A.; Rossi, A.; Rocca, P.; Bertolino, A.; Aguglia, E.; Amore, M.; Andriola, I.; Bellomo, A.; Biondi, M.; Cuomo, A.; dell'Osso, L.; Favaro, A.; Gambi, F.; Giordano, G. M.; Girardi, P.; Marchesi, C.; Monteleone, P.; Montemagni, C.; Niolu, C.; Oldani, L.; Pacitti, F.; Pinna, F.; Roncone, R.; Vita, A.; Zeppegno, P.; Maj, M.; Patriarca, Sara; Pietrafesa, Daria; Aiello, Carmen; Longo, Luisa; Barone, Marina; Romano, Raffaella; Atti, Anna Rita; Barlati, Stefano; Deste, Giacomo; Valsecchi, Paolo; Carpiniello, Bernardo; Tusconi, Massimo; Puddu, Laura; Signorelli, Maria Salvina; Cannavò, Dario; Minutolo, Giuseppe; Corbo, Mariangela; Montemitro, Chiara; Baroni, Gaia; Altamura, Mario; La Montagna, Maddalena; Carnevale, Raffaella; Murri, Martino Belvederi; Calcagno, Pietro; Bugliani, Michele; Pizziconi, Giulia; Logozzo, Francesca; Rossi, Rodolfo; Giusti, Laura; Salza, Anna; Malavolta, Maurizio; Orsenigo, Giulia; Grassi, Silvia; De Bartolomeis, Andrea; Gramaglia, Carla; Gattoni, Eleonora; Gambaro, Eleonora; Tenconi, Elena; Ferronato, Luisa; Collantoni, Enrico; Tonna, Matteo; Ossola, Paolo; Gerra, Maria Lidia; Carmassi, Claudia; Cremone, Ivan Mirko; Carpita, Barbara; Buzzanca, Antonio; Girardi, Nicoletta; Frascarelli, Marianna; Del Casale, Antonio; Comparelli, Anna; Corigliano, Valentina; Siracusano, Alberto; Di Lorenzo, Giorgio; Ribolsi, Michele; Corrivetti, Giulio; Bartoli, Luca; Del Buono, Gianfranco; Fagiolini, Andrea; Bolognesi, Simone; Goracci, Arianna; Mancini, Irene; Bava, Irene; Cardillo, Simona |
| Contributors: | Bucci, P.; Galderisi, S.; Mucci, A.; Rossi, A.; Rocca, P.; Bertolino, A.; Aguglia, E.; Amore, M.; Andriola, I.; Bellomo, A.; Biondi, M.; Cuomo, A.; Dell'Osso, L.; Favaro, A.; Gambi, F.; Giordano, G. M.; Girardi, P.; Marchesi, C.; Monteleone, P.; Montemagni, C.; Niolu, C.; Oldani, L.; Pacitti, F.; Pinna, F.; Roncone, R.; Vita, A.; Zeppegno, P.; Maj, M.; Patriarca, Sara; Pietrafesa, Daria; Aiello, Carmen; Longo, Luisa; Barone, Marina; Romano, Raffaella; Atti, Anna Rita; Barlati, Stefano; Deste, Giacomo; Valsecchi, Paolo; Carpiniello, Bernardo; Tusconi, Massimo; Puddu, Laura; Signorelli, Maria Salvina; Cannavò, Dario; Minutolo, Giuseppe; Corbo, Mariangela; Montemitro, Chiara; Baroni, Gaia; Altamura, Mario; La Montagna, Maddalena; Carnevale, Raffaella; Murri, Martino Belvederi; Calcagno, Pietro; Bugliani, Michele; Pizziconi, Giulia; Logozzo, Francesca; Rossi, Rodolfo; Giusti, Laura; Salza, Anna; Malavolta, Maurizio; Orsenigo, Giulia; Grassi, Silvia; De Bartolomeis, Andrea; Gramaglia, Carla; Gattoni, Eleonora; Gambaro, Eleonora; Tenconi, Elena; Ferronato, Luisa; Collantoni, Enrico; Tonna, Matteo; Ossola, Paolo; Gerra, Maria Lidia; Carmassi, Claudia; Cremone, Ivan Mirko; Carpita, Barbara; Buzzanca, Antonio; Girardi, Nicoletta; Frascarelli, Marianna; Del Casale, Antonio; Comparelli, Anna; Corigliano, Valentina; Siracusano, Alberto; Di Lorenzo, Giorgio; Ribolsi, Michele; Corrivetti, Giulio; Bartoli, Luca; Del Buono, Gianfranco; Fagiolini, Andrea; Bolognesi, Simone; Goracci, Arianna; Mancini, Irene; Bava, Irene; Cardillo, Simona |
| Publication Year: | 2018 |
| Subject Terms: | avolition; cognitive functioning; poor emotion expression; premorbid adjustment; primary negative symptom; Psychiatry and Mental Health |
| Description: | Objective: The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment. Method: Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first-degree relatives and healthy controls. Its associations with psychopathology, cognition, and real-life functioning were investigated. The associations of PA with primary negative symptoms and their two factors were explored. Results: We found an impairment of academic and social PA in patients (P ≤ 0.000001) and an impairment of academic aspects of early adjustment in relatives (P ≤ 0.01). Patients with poor PA showed greater severity of negative symptoms (limited to avolition after excluding the effect of depression/parkinsonism), working memory, social cognition, and real-life functioning (P ≤ 0.01 to ≤0.000001). Worse academic and social PA were associated with greater severity of psychopathology, cognitive impairment, and real-life functioning impairment (P ≤ 0.000001). Regression analyses showed that worse PA in the academic domain was mainly associated to the impairment of working memory, whereas worse PA in the social domain to avolition (P ≤ 0.000001). Conclusion: Our findings suggest that poor early adjustment may represent a marker of vulnerability to schizophrenia and highlight the need for preventive/early interventions based on psychosocial and/or cognitive programs. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/29984409; info:eu-repo/semantics/altIdentifier/wos/WOS:000441867700007; volume:138; firstpage:253; lastpage:266; numberofpages:14; journal:ACTA PSYCHIATRICA SCANDINAVICA; http://hdl.handle.net/11386/4717611 |
| DOI: | 10.1111/acps.12938 |
| DOI: | 10.1111/(ISSN)1600-0447 |
| Availability: | http://hdl.handle.net/11386/4717611; https://doi.org/10.1111/acps.12938; http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0447 |
| Accession Number: | edsbas.321A3FC8 |
| Database: | BASE |