| Title: |
Methods and theoretical approaches: ; Genetic animal models of emotional disorders and convergence with human data |
| Authors: |
St Pierre, Celine L; Sharif, Kayvon; Funsten, Emily; Palmer, Abraham A; Parker, Clarissa C |
| Source: |
Genes, brain, and emotions ; page 77-96 ; ISBN 0198793014 9780198793014 9780191834745 |
| Publisher Information: |
Oxford University PressOxford |
| Publication Year: |
2019 |
| Description: |
Anxiety, depression, and stress-related disorders are complex neurobehavioral diseases with a partially heritable genetic basis. This chapter explores how the appropriate use of rodent models can illuminate the neurobiological underpinnings of these disorders. Because these psychiatric disorders are uniquely human, rodent models typically model individual components rather than trying to recapitulate the disease itself. This chapter considers how both intermediate phenotypes and rodent models fit into this framework. Integrating these two concepts can be bidirectional: studying intermediate phenotypes in rodent models may lead to identifying risk genes that are present in humans, or human studies may uncover genetic variants linked to intermediate phenotypes and subsequent experiments in rodents may be employed to examine the causal mechanisms. This dynamic interplay is explored throughout the chapter. |
| Document Type: |
book part |
| Language: |
English |
| ISBN: |
978-0-19-879301-4; 978-0-19-183474-5; 0-19-879301-4; 0-19-183474-2 |
| DOI: |
10.1093/oso/9780198793014.003.0007 |
| Availability: |
http://dx.doi.org/10.1093/oso/9780198793014.003.0007; https://academic.oup.com/book/chapter-pdf/40153120/oso-9780198793014-chapter-7.pdf |
| Accession Number: |
edsbas.329C90CF |
| Database: |
BASE |