| Title: |
Recovery from Covid-19 critical illness: a secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial |
| Authors: |
Pauley, E; Drake, TM; Griffith, DM; Sigfrid, L; Lone, NI; Harrison, EM; Baillie, JK; Scott, JT; Walsh, TS; Semple, MG; Docherty, AB |
| Contributors: |
Society, The Intensive Care |
| Publisher Information: |
SAGE Publications |
| Publication Year: |
2022 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Background: We aimed to compare the prevalence and severity of fatigue in survivors of Covid-19 versus non-Covid-19 critical illness, and to explore potential associations between baseline characteristics and worse recovery. Methods: We conducted a secondary analysis of two prospectively collected datasets. The population included was 92 patients who received invasive mechanical ventilation (IMV) with Covid-19, and 240 patients who received IMV with non-Covid-19 illness before the pandemic. Follow-up data were collected post-hospital discharge using self-reported questionnaires. The main outcome measures were self-reported fatigue severity and the prevalence of severe fatigue (severity >7/10) 3 and 12-months post-hospital discharge. Results: Covid-19 IMV-patients were significantly younger with less prior comorbidity, and more males, than pre-pandemic IMV-patients. At 3-months, the prevalence (38.9% [7/18] vs. 27.1% [51/188]) and severity (median 5.5/10 vs 5.0/10) of fatigue were similar between the Covid-19 and pre-pandemic populations, respectively. At 6-months, the prevalence (10.3% [3/29] vs. 32.5% [54/166]) and severity (median 2.0/10 vs. 5.7/10) of fatigue were less in the Covid-19 cohort. In the total sample of IMV-patients included (i.e. all Covid-19 and pre-pandemic patients), having Covid-19 was significantly associated with less severe fatigue (severity |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1177/17511437211052226 |
| DOI: |
10.1177/17511437211052226 |
| Availability: |
https://doi.org/10.1177/17511437211052226; https://ora.ox.ac.uk/objects/uuid:d58d4d71-7935-4ee8-a742-9843dc488d19 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.329DB887 |
| Database: |
BASE |