| Title: |
PF712 PHYSICIANS’ PERCEPTIONS ON CAUSES OF PRIMARY AND SECONDARY ITP AND LEADING CAUSES OF MISDIAGNOSIS: RESULTS FROM THE ITP WORLD IMPACT SURVEY (I‐WISH) |
| Authors: |
Bussel, J.B.; Tomiyama, Y.; Michel, M.; Provan, D.; Hou, M.; Santoro, C.; Kruse, A.; Kruse, C.; Morgan, M.; Lovrencic, B.; Bailey, T.; Stankovic, M.; Ghanima, W. |
| Source: |
HemaSphere ; volume 3, issue S1, page 311 ; ISSN 2572-9241 2572-9241 |
| Publisher Information: |
Wiley |
| Publication Year: |
2019 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Background: Immune thrombocytopenia (ITP) is a heterogeneous syndrome with variable clinical manifestations across patients (pts), which makes diagnosis challenging and requires tailored investigations. There is a need for improved accuracy and novel testing in diagnosing ITP and better use of existing tests, e.g. reticulated platelets, platelet antibodies. Aims: I‐WISh studied the burden of ITP and its impact on quality of life using a global pt and physicians sampling frame. This analysis reports physicians’ perspectives on the difficulties inherent in ITP diagnosis. Methods: I‐WISh is a cross‐sectional survey of 1507 ITP pts and 472 physicians across 13 countries. Participants (pts and physicians) completed a 30‐minute online survey that included demographics, signs and symptoms, impact of symptoms, and pt–physician relationships. A steering committee of expert physicians and pt advocacy ITP specialists designed and endorsed the survey materials. All physician‐reported data were collected from a single physician survey, which asked physicians about their experience and perceptions of managing ITP patients. Physicians assigned a rank of 1, 2, or 3 from a list of 15 conditions that could be misdiagnosed as ITP. Results: 472 physicians with a mean number of ITP pts (SD) of 34 (50) and mean (SD) of 18 (36) newly diagnosed pts in the past year completed the survey. According to physicians’ recollections, 72% of ITP pts have primary ITP and the remaining 28% have secondary ITP. The survey revealed that exclusion of other disorders was perceived as the leading cause of delays in making an accurate diagnosis of ITP (68%). 53% of physicians indicated misdiagnosis as a contributing factor in delayed diagnosis, with 71% reporting that pts were misdiagnosed 1–25% of the time. Other contributors to delayed diagnosis were access to diagnostic examination (55%) and time to refer pts to a specialist (58%). Out of 441 responses, causes of secondary ITP featured in the top 3 were systemic lupus erythematosus (46%), ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1097/01.hs9.0000561132.23290.ae |
| DOI: |
10.1097/01.HS9.0000561132.23290.ae |
| Availability: |
http://dx.doi.org/10.1097/01.hs9.0000561132.23290.ae; https://onlinelibrary.wiley.com/doi/pdf/10.1097/01.HS9.0000561132.23290.ae |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.32A419AF |
| Database: |
BASE |