| Title: |
The influence of astrocytic leaflet motility on ionic signalling and homeostasis at active synapses |
| Authors: |
Toman, Marinus; Wade, John Joseph; Verkhratsky, Alexei; Dallas, Mark; Bithell, Angela; Flanagan, Bronac; Harkin, Jim; McDaid, Liam |
| Publisher Information: |
Nature Publishing Group |
| Publication Year: |
2023 |
| Collection: |
CentAUR: Central Archive at the University of Reading |
| Description: |
Astrocytes display a highly complex, spongiform morphology, with their fine terminal processes (leaflets) exercising dynamic degrees of synaptic coverage, from touching and surrounding the synapse to being retracted from the synaptic region. In this paper, a computational model is used to reveal the effect of the astrocyte-synapse spatial relationship on ionic homeostasis. Specifically, our model predicts that varying degrees of astrocyte leaflet coverage influences concentrations of K+, Na+ and Ca2+, and results show that leaflet motility strongly influences Ca2+ uptake, as well as glutamate and K+ to a lesser extent. Furthermore, this paper highlights that an astrocytic leaflet that is in proximity to the synaptic cleft loses the ability to form a Ca2+ microdomain, whereas when the leaflet is remote from the synaptic cleft, a Ca2+ microdomain can form. This may have implications for Ca2+-dependent leaflet motility. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
2045-2322 |
| Relation: |
https://centaur.reading.ac.uk/111115/8/s41598-023-30189-8.pdf; https://centaur.reading.ac.uk/111115/1/41598_2023_30189_Author.pdf; Toman, M., Wade, J. J., Verkhratsky, A., Dallas, M. orcid:0000-0002-5190-0522 , Bithell, A. , Flanagan, B., Harkin, J. and McDaid, L. (2023) The influence of astrocytic leaflet motility on ionic signalling and homeostasis at active synapses. Scientific Reports, 13 (1). 3050. ISSN 2045-2322 doi:10.1038/s41598-023-30189-8 |
| Availability: |
https://centaur.reading.ac.uk/111115/; https://centaur.reading.ac.uk/111115/1/41598_2023_30189_Author.pdf |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.32A44262 |
| Database: |
BASE |