Anti-dopamine D2 receptor antibodies in chronic tic disorders
| Title: | Anti-dopamine D2 receptor antibodies in chronic tic disorders |
|---|---|
| Authors: | Addabbo F.; Baglioni V.; Schrag A.; Schwarz M. J.; Dietrich A.; Hoekstra P. J.; Martino D.; Buttiglione M.; Anastasiou Z.; Apter A.; Ball J.; Bartolini E.; Benaroya-Milshtein N.; Bodmer B.; Bognar E.; Burger B.; Buse J.; Cardona F.; Correa Vela M.; Creti R.; Debes N. M.; Efstratiou A.; Ferro M. C.; Fremer C.; Garcia-Delgar B.; Gariup M.; Georgitsi M.; Gulisano M.; Hagen A.; Hagstrom J.; Hedderly T. J.; Heyman I.; Huyser C.; Imperi M.; Karagiannidis I.; Laviola G.; Macri S.; Madruga-Garrido M.; Margarit I.; Marotta A.; Meier U. C.; Mir P.; Moll N.; Morer A.; Muller-Vahl K.; Munchau A.; Nagy P.; Neri V.; Openneer T. J. C.; Orefici G.; Paschou P.; Perianez A.; Pellico V. A.; Petruzzelli O.; Plessen K.; Porcelli C.; Redondo M.; Rizzo R.; Roazzi P.; Roessner V.; Ruhrman D.; Schnell J. M. L.; Schutze G. A.; Silvestri P. R.; Skov L.; Steinberg T.; Stober S.; Tallon M.; Gloor F. T.; Walitza S.; Tubing J.; Turner V.; Weidinger E.; Tarnok Z. |
| Contributors: | Addabbo, F.; Baglioni, V.; Schrag, A.; Schwarz, M. J.; Dietrich, A.; Hoekstra, P. J.; Martino, D.; Buttiglione, M.; Anastasiou, Z.; Apter, A.; Ball, J.; Bartolini, E.; Benaroya-Milshtein, N.; Bodmer, B.; Bognar, E.; Burger, B.; Buse, J.; Cardona, F.; Correa Vela, M.; Creti, R.; Debes, N. M.; Efstratiou, A.; Ferro, M. C.; Fremer, C.; Garcia-Delgar, B.; Gariup, M.; Georgitsi, M.; Gulisano, M.; Hagen, A.; Hagstrom, J.; Hedderly, T. J.; Heyman, I.; Huyser, C.; Imperi, M.; Karagiannidis, I.; Laviola, G.; Macri, S.; Madruga-Garrido, M.; Margarit, I.; Marotta, A.; Meier, U. C.; Mir, P.; Moll, N.; Morer, A.; Muller-Vahl, K.; Munchau, A.; Nagy, P.; Neri, V.; Openneer, T. J. C.; Orefici, G.; Paschou, P.; Perianez, A.; Pellico, V. A.; Petruzzelli, O.; Plessen, K.; Porcelli, C.; Redondo, M.; Rizzo, R.; Roazzi, P.; Roessner, V.; Ruhrman, D.; Schnell, J. M. L.; Schutze, G. A.; Silvestri, P. R.; Skov, L.; Steinberg, T.; Stober, S.; Tallon, M.; Gloor, F. T.; Walitza, S.; Tubing, J.; Turner, V.; Weidinger, E.; Tarnok, Z. |
| Publication Year: | 2020 |
| Collection: | Università degli Studi di Bari Aldo Moro: CINECA IRIS |
| Subject Terms: | Cronic Tic Disorders; autoantibodies; Tourette syndrom; D2R |
| Description: | Aim: To investigate the association between circulating anti-dopamine D2 receptor (D2R) autoantibodies and the exacerbation of tics in children with chronic tic disorders (CTDs). Method: One hundred and thirty-seven children with CTDs (108 males, 29 females; mean age [SD] 10y 0mo [2y 7mo], range 4–16y) were recruited over 18 months. Patients were assessed at baseline, at tic exacerbation, and at 2 months after exacerbation. Serum anti-D2R antibodies were evaluated using a cell-based assay and blinded immunofluorescence microscopy scoring was performed by two raters. The association between visit type and presence of anti-D2R antibodies was measured with McNemar’s test and repeated-measure logistic regression models, adjusting for potential demographic and clinical confounders. Results: At exacerbation, 11 (8%) participants became anti-D2R-positive (‘early peri-exacerbation seroconverters’), and nine (6.6%) became anti-D2R-positive at post-exacerbation (‘late peri-exacerbation seroconverters’). The anti-D2R antibodies were significantly associated with exacerbations when compared to baseline (McNemar’s odds ratio=11, p=0.003) and conditional logistic regression confirmed this association (Z=3.49, p |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/32644201; info:eu-repo/semantics/altIdentifier/wos/WOS:000546418300001; volume:62; issue:10; firstpage:1205; lastpage:1212; numberofpages:8; journal:DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY; https://hdl.handle.net/11586/310004 |
| DOI: | 10.1111/dmcn.14613 |
| Availability: | https://hdl.handle.net/11586/310004; https://doi.org/10.1111/dmcn.14613 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: | edsbas.32BB0A45 |
| Database: | BASE |