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Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

Title:	Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis
Authors:	Sara Trabanelli; Mathieu F. Chevalier; Amaia Martinez-Usatorre; Alejandra Gomez-Cadena; Bérengère Salomé; Mariangela Lecciso; Valentina Salvestrini; Grégory Verdeil; Julien Racle; Cristina Papayannidis; Hideaki Morita; Irene Pizzitola; Camille Grandclément; Perrine Bohner; Elena Bruni; Mukul Girotra; Rani Pallavi; Paolo Falvo; Elisabeth Oppliger Leibundgut; Gabriela M. Baerlocher; Carmelo Carlo-Stella; Daniela Taurino; Armando Santoro; Orietta Spinelli; Alessandro Rambaldi; Emanuela Giarin; Giuseppe Basso; Cristina Tresoldi; Fabio Ciceri; David Gfeller; Cezmi A. Akdis; Luca Mazzarella; Saverio Minucci; Pier Giuseppe Pelicci; Emanuela Marcenaro; Andrew N. J. McKenzie; Dominique Vanhecke; George Coukos; Domenico Mavilio; Antonio Curti; Laurent Derré; Camilla Jandus
Source:	Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Publisher Information:	Nature Portfolio
Publication Year:	2017
Collection:	Directory of Open Access Journals: DOAJ Articles
Subject Terms:	Science
Description:	Group 2 innate lymphoid cells (ILC2s) modulate inflammatory and allergic responses, but their function in cancer immunity is still unclear. Here the authors show that, in acute promyelocytic leukaemia, tumour-activated ILC2s secrete IL-13 to induce myeloid-derived suppressor cells and support tumour growth.
Document Type:	article in journal/newspaper
Language:	English
Relation:	https://doi.org/10.1038/s41467-017-00678-2; https://doaj.org/toc/2041-1723; https://doaj.org/article/acd6edf30f5b42e78199d6bb93f923c9
DOI:	10.1038/s41467-017-00678-2
Availability:	https://doi.org/10.1038/s41467-017-00678-2; https://doaj.org/article/acd6edf30f5b42e78199d6bb93f923c9
Accession Number:	edsbas.32DF2E23
Database:	BASE