Interim Analysis of MEDICI:Mammographic Predictors of Cancer Recurrence after Breast Conservation and Adjuvant Endocrine Therapy
| Title: | Interim Analysis of MEDICI:Mammographic Predictors of Cancer Recurrence after Breast Conservation and Adjuvant Endocrine Therapy |
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| Authors: | Savaridas, Sarah; Marshall, Andrew; Vinnicombe, Sarah; Halling-Brown, Mark; Ali, Kulsam; Whelehan, Patsy; Evans, Andrew; Astley, Sue; Healy, Nuala; Sharma, Ashwini; Drummond, Sonya; Nash, Jonathon; Muthyala, Sreenivas; Muscat, Elizabeth; Telesca, Marianna; Dunn, Janet |
| Source: | Savaridas, S, Marshall, A, Vinnicombe, S, Halling-Brown, M, Ali, K, Whelehan, P, Evans, A, Astley, S, Healy, N, Sharma, A, Drummond, S, Nash, J, Muthyala, S, Muscat, E, Telesca, M & Dunn, J 2024, 'Interim Analysis of MEDICI : Mammographic Predictors of Cancer Recurrence after Breast Conservation and Adjuvant Endocrine Therapy', Paper presented at British Society of Breast Radiology Annual Scientific Meeting 2024, Liverpool, United Kingdom, 3/11/24 - 5/11/24. |
| Publication Year: | 2024 |
| Collection: | Discovery - University of Dundee Online Publications |
| Description: | Background: Mammographic density (MD) is a well-established breast cancer risk factor. Decreasing MD has been demonstrated to be a risk-reduction biomarker in a landmark chemoprevention study in high-risk women. A few small studies suggest that a decreasing MD in women taking adjuvant endocrine therapy (AET) may be associated with a lower risk of recurrence and breast cancer specific death. Aim: This interim analysis aims to measure inter and intra-reader variability of MD classification within a current study (MEDICI) investigating whether a reduction in MD after one and/or three years in women taking AET is associated with a lower risk of breast cancer recurrence and death compared to no reduction. Methods: Retrospective cohort study, generated from a subset of participants from the Mammo-50 trial. Eleven readers assessed MD using a 0 to 100% visual analogue scale (VAS), scoring mammograms from time of diagnosis and at one and three years after diagnosis. A subset of four readers re-analysed the mammograms. Inter and intra- reader agreement were estimated using intra-class correlation coefficients (ICC). Results: Eleven readers classified MD in 50 patients at three timepoints (150 mammograms), using the VAS. Four readers re-interpreted all 150 mammograms. The ICC between all 11 readers (inter-reader agreement) was 0.80 (95% confidence interval (CI): 0.77-0.84). The ICC within readers (intra-reader agreement) was 0.86 (95% CI 0.77-0.91). Conclusion: Interim analysis demonstrates good inter- and intra-reader agreement for assessment of MD on VAS, suggesting validity of the human MD assessment to be performed within the MEDICI study. |
| Document Type: | conference object |
| Language: | English |
| Availability: | https://discovery.dundee.ac.uk/en/publications/0292c522-9b16-434c-a401-655195aa27a6; https://www.delegate-reg.co.uk/bsbr2024/programme |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| Accession Number: | edsbas.3328F7D2 |
| Database: | BASE |