Outcomes for Sinonasal Undifferentiated Carcinoma (SNUC): An International Multi-Center Retrospective Cohort Study
| Title: | Outcomes for Sinonasal Undifferentiated Carcinoma (SNUC): An International Multi-Center Retrospective Cohort Study |
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| Authors: | Jacklyn Liu; Yoko Takahashi; Umar Rehman; Mario Turri-Zanoni; Davide Mattavelli; Nicholas Counsell; Marco Ferrari; Vittorio Rampinelli; William Vermi; Davide Lombardi; Rami Saade; Ki Park; Oscar Emanuel; Volker Schartinger; Alessandro Franchi; Carla Facco; Fausto Sessa; Simonetta Battocchio; Patrick Eriksen; Simone Bendtsen; Kathrine Kronberg Jakobsen; Mohamed el Haddouchi; Roberta Maragliano; Giedrius Lelkaitis; Anirudh Saraswathula; Raman Kaur; Wojciech Mydlarz; Murugappan Ramanathan; Masaru Ishii; Manas Dave; Tim Fenton; Alison Lim; Saleh Okhovat; Gyleen Elegio; Charles Dupin; Pierre Pouvreau; Juliette Thariat; Laurence Digue; Francois-Regis Ferrand; Valerie Costes-Martineau; Claire Castain; Héloïse De Kermadec; Justin Hintze; James O’Neill; Peter Lacy; Francis Vaz; Paul O’Flynn; David Howard; Paul Stimpson; Simon Wang; Gary Royle; Christopher Steele; Amrita Jay; Dawn Carnell; Martin Forster; David Thomson; Christian von Buchwald; Robbie Woods; Jose Lllorente; Mario Hermsen; Philipp Jurmeister; David Capper; Gary Gallia; Joshua Tay; Ahmed Mohyeldin; Juan Fernandez-Miranda; Quynh-Thu Le; Robert West; Zara Patel; Jayakar Nayak; Peter Hwang; Fabio Facchetti; Piero Nicolai; Renata Ferrarotto; Jack Phan; Paolo Bossi; Paolo Castelnuovo; Antoine Moya-Plana; Benjamin Verillaud; Cathie Garnis; Andrew Thamboo; Felicia Olawuni; Eric Moore; Garret Choby; Devyani Lal; Neal Akhave; Diana Bell; Shirley Su; Valerie Lund; Nyall London; Ehab Hanna; Matt Lechner |
| Source: | Cancers ; Volume 18 ; Issue 3 ; Pages: 366 |
| Publisher Information: | Multidisciplinary Digital Publishing Institute |
| Publication Year: | 2026 |
| Collection: | MDPI Open Access Publishing |
| Subject Terms: | sinonasal undifferentiated carcinoma; SNUC; survival outcomes |
| Description: | Background: Sinonasal undifferentiated carcinoma (SNUC) is an extremely rare, high-grade, and aggressive tumor of the sinonasal tract. Due to the rarity of this malignancy, current treatment guidelines are based on small and often/mainly single-center retrospective datasets. In the absence of a universally accepted standard of care for SNUC, treatment approaches vary across countries and institutions, reflecting real-world clinical practice. The primary aim of this study was to describe real-world treatment and outcomes for patients with confirmed SNUC. Methods: This was an international, multi-center, retrospective, observational cohort study that pooled patients into the largest SNUC dataset to date. Fifteen centers were enrolled to contribute data, including seven from Europe, four from the United States, three from the United Kingdom, and one from Canada. In the absence of a universally accepted standard of care for SNUC, treatment approaches varied across countries and institutions, reflecting real-world clinical practice. Patients included were those with histologically confirmed SNUC who were treated between 1997 and 2021. Results: This study yielded 485 patients treated for SNUC. The median age at diagnosis was 55.6 years (IQR: 44.5–67.6), and 63.7% were male. Most cases presented at advanced stages, with 70.8% as T4a or T4b. Overall survival (OS) outcomes were available for 412 patients, with a median follow-up of 26.0 months. The 5- and 10-year OS were 47.2% (95% CI: 40.8–53.3%) and 39.6% (95% CI: 32.5–46.6%), respectively. Advanced age, dichotomized T-stage (T4a/b vs. T1–3), M-stage, and orbital involvement were significant poor prognostic factors on univariable analysis (p’s < 0.01). On multivariable analysis, orbital involvement (HR: 2.73, 95% CI: 1.42–5.27, p = 0.003) and distance metastasis stage (HR: 3.00, 95% CI: 1.25–7.21, p = 0.014) were both independently associated with worse OS. Conclusions: This observational study presents the largest multi-center cohort analysis of SNUC to date, ... |
| Document Type: | text |
| File Description: | application/pdf |
| Language: | English |
| Relation: | Cancer Therapy; https://dx.doi.org/10.3390/cancers18030366 |
| DOI: | 10.3390/cancers18030366 |
| Availability: | https://doi.org/10.3390/cancers18030366 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.3357E7D6 |
| Database: | BASE |