| Title: |
The impact of race/ethnicity on the clinical outcomes of people with type 2 diabetes admitted to hospital with COVID-19: an observational multi-national analysis |
| Authors: |
Wilmot, Emma; Wild, Sarah H; Ruan, Yue; Hadjadj, Samy; Wargny, Matthieu; Williams, Myia S; Saulnier, Pierre-Jean; Zhu, Xu; Ryder, Robert EJ; Pekmezaris, Renee; Marre, Michel; Field, Benjamin CT; Narendran, Parth; Harris, Sophie; Gautier, Jean-François; Patel, Dipesh; Várnai, Kinga A; Davies, Jim; Roussel, Ronan; Rea, Rustam; Gourdy, Pierre; Cariou, Bertrand; Myers, Alyson; Khunti, Kamlesh |
| Source: |
British Journal of Diabetes; Vol. 23 No. 1 (2023): June 2023; 23-30 ; 2397-6241 ; 2397-6233 |
| Publisher Information: |
ABCD (Diabetes Care) Ltd |
| Publication Year: |
2023 |
| Collection: |
British Journal of Diabetes |
| Subject Terms: |
ethnicity; COVID-19; intensive care; mortality; race; type 2 diabetes |
| Description: |
Aims: To describe the relationship between race/ethnicity and adverse outcomes related to coronavirus disease 2019 (COVID-19) in adults with T2DM admitted to hospital in the UK, France and USA. Methods: Study data from the UK ABCD nationwide COVID- 19 audit, the French CORONADO nationwide initiative and the USA AMERICADO multi-centre study were analysed to assess the association between race/ethnicity and severe COVID-19. Severe COVID-19 was defined as death in hospital and/or admission to the intensive care unit (ICU). Logistic regression models were used to generate age-adjusted odds ratios. Results: Data from 3,471 patients in the ABCD audit, from 2,451 CORONADO patients and from 9,321 AMERICADO patients admitted with COVID-19 and T2DM were analysed. Race/ethnicity data were available for 3,410 (98%), 2,173 (89%) and 8,893 (95%) patients, respectively. In the UK ABCD audit cohort, Asian and Black race/ethnicity were associated with an increased risk of death/ICU admission compared to White when adjusted for age and sex (OR 2.14; 1.38-3.29 and OR 2.09; 1.17-3.74, respectively). When adjusted for additional confounders the association was stronger (Asian OR 2.88; 1.72-4.82 and Black OR 2.20; 1.12-4.30). In the CORONADO cohort Middle Eastern/North African race/ethnicity was protective against death/ICU admission (OR 0.57; 0.36-0.91). There was no association between ethnicity and death alone in the AMERICADO dataset. Conclusion: In those with T2DM admitted to hospital with COVID-19, a non-White race/ethnicity was associated with higher risk of death/ICU admission in the UK ABCD data but not in French CORONADO or USA AMERICADO datasets. Further research is required to improve our understanding of the observed discrepancies in outcomes. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf; text/html |
| Language: |
English |
| Relation: |
https://bjd-abcd.com/index.php/bjd/article/view/1095/1367; https://bjd-abcd.com/index.php/bjd/article/view/1095/1369 |
| DOI: |
10.15277/bjd.2023.411 |
| Availability: |
https://bjd-abcd.com/index.php/bjd/article/view/1095; https://doi.org/10.15277/bjd.2023.411 |
| Rights: |
Copyright (c) 2023 British Journal of Diabetes |
| Accession Number: |
edsbas.3358AB6F |
| Database: |
BASE |