| Title: |
Development and Validation of a Multi-institutional Nomogram of Outcomes for PSMA-PET–Based Salvage Radiotherapy for Recurrent Prostate Cancer |
| Authors: |
Zamboglou, Constantinos; Peeken, Jan; Janbain, Ali; Katsahian, Sandrine; Strouthos, Iosif; Ferentinos, Konstantinos; Farolfi, Andrea; Koerber, Stefan; Debus, Juergen; Vogel, Marco; Combs, Stephanie; Vrachimis, Alexis; Morganti, Alessio Giuseppe; Spohn, Simon; Shelan, Mohamed; Aebersold, Daniel; Grosu, Anca-Ligia; Ceci, Francesco; Henkenberens, Christoph; Kroeze, Stephanie; Guckenberger, Matthias; Fanti, Stefano; Belka, Claus; Bartenstein, Peter; Hruby, George; Scharl, Sophia; Wiegel, Thomas; Emmett, Louise; Arnoux, Armelle; Schmidt-Hegemann, Nina-Sophie |
| Contributors: |
Albert-Ludwigs-Universität Freiburg = University of Freiburg; Technische Universität Munchen = Technical University Munich = Université Technique de Munich (TUM); CIC - HEGP (CIC 1418); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou APHP (HEGP); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); Health data- and model- driven Knowledge Acquisition (HeKA); Centre Inria de Paris; Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)); École Pratique des Hautes Études (EPHE); Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE); Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité); Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)); Service d’Épidémiologie et de Recherche Clinique CHU HEGP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO); Limassol General Hospital; IRCCS Azienda Ospedaliero-Universitaria di Bologna (AOUB); Heidelberg University Hospital Heidelberg; Inselspital Bern; Istituto Clinico Humanitas Milan (IRCCS Milan); Humanitas University Milan (Hunimed); Medizinische Hochschule Hannover = Hannover Medical School (MHH); Universität Zürich Zürich = University of Zurich (UZH); Institut für Informatik München/Munich (LMU); Ludwig Maximilian University Munich = Ludwig Maximilians Universität München (LMU); Royal North Shore Hospital (RNSH); Universitätsklinikum Ulm - University Hospital of Ulm; St. Vincent's Hospital, Sydney; Hôpital Cantonal Aarau = Kantonsspital Aarau (KSA); ANR-18-PERM-0005,PersoProCaRisk(2018) |
| Source: |
EISSN: 2574-3805 ; JAMA Network Open ; https://hal.science/hal-04343654 ; JAMA Network Open, 2023, 6 (5), pp.e2314748. ⟨10.1001/jamanetworkopen.2023.14748⟩ |
| Publisher Information: |
CCSD; American Medical Association |
| Publication Year: |
2023 |
| Collection: |
Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| Subject Terms: |
[SDV.CAN]Life Sciences [q-bio]/Cancer |
| Description: |
International audience ; Importance Prostate-specific antigen membrane positron-emission tomography (PSMA-PET) is increasingly used to guide salvage radiotherapy (sRT) after radical prostatectomy for patients with recurrent or persistent prostate cancer. Objective To develop and validate a nomogram for prediction of freedom from biochemical failure (FFBF) after PSMA-PET–based sRT. Design, Setting, and Participants This retrospective cohort study included 1029 patients with prostate cancer treated between July 1, 2013, and June 30, 2020, at 11 centers from 5 countries. The initial database consisted of 1221 patients. All patients had a PSMA-PET scan prior to sRT. Data were analyzed in November 2022. Exposures Patients with a detectable post–radical prostatectomy prostate-specific antigen (PSA) level treated with sRT to the prostatic fossa with or without additional sRT to pelvic lymphatics or concurrent androgen deprivation therapy (ADT) were eligible. Main Outcomes and Measures The FFBF rate was estimated, and a predictive nomogram was generated and validated. Biochemical relapse was defined as a PSA nadir of 0.2 ng/mL after sRT. Results In the nomogram creation and validation process, 1029 patients (median age at sRT, 70 years [IQR, 64-74 years]) were included and further divided into a training set (n = 708), internal validation set (n = 271), and external outlier validation set (n = 50). The median follow-up was 32 months (IQR, 21-45 months). Based on the PSMA-PET scan prior to sRT, 437 patients (42.5%) had local recurrences and 313 patients (30.4%) had nodal recurrences. Pelvic lymphatics were electively irradiated for 395 patients (38.4%). All patients received sRT to the prostatic fossa: 103 (10.0%) received a dose of less than 66 Gy, 551 (53.5%) received a dose of 66 to 70 Gy, and 375 (36.5%) received a dose of more than 70 Gy. Androgen deprivation therapy was given to 325 (31.6%) patients. On multivariable Cox proportional hazards regression analysis, pre-sRT PSA level (hazard ratio [HR], 1.80 [95% CI, ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1001/jamanetworkopen.2023.14748 |
| Availability: |
https://hal.science/hal-04343654; https://hal.science/hal-04343654v1/document; https://hal.science/hal-04343654v1/file/zamboglou_2023_oi_230452_1683899167.63195.pdf; https://doi.org/10.1001/jamanetworkopen.2023.14748 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.3369FD7A |
| Database: |
BASE |