| Title: |
ANTIPROLIFERATIVE AND IN SILICO ADMET STUDY OF NEW 4-(PIPERIDIN-1-YLMETHYL)-2- (THIOPHEN-2-YL) QUINOLINE ANALOGUES |
| Authors: |
S, Harishkumar; Nd, Satyanarayan; Sm, Santhosha |
| Source: |
Asian Journal of Pharmaceutical and Clinical Research; Vol 11 Issue 4 April 2018; 306-313 ; 2455-3891 ; 0974-2441 |
| Publisher Information: |
Innovare Academic Sciences Pvt Ltd |
| Publication Year: |
2018 |
| Collection: |
Innovare Academic Sciences: E-Journals |
| Subject Terms: |
MTT assay; In silico; T-47D; HeLa; HepG2; MCF-7; Molinspiration; Drug design |
| Description: |
 Objective: Synthesis and antiproliferative study of novel 4-(piperidin-1-ylmethyl)-2-(thiophen-2-yl) quinoline 7(a-j) derivatives.Methods: 4-(piperidin-1-ylmethyl)-2-(thiophen-2-yl) quinolines were synthesized by the addition of 4-(chloromethyl)-2-(thiophen-2-yl) quinoline (0.01 mol), piperidine (0.01 mol) in DMF (10 v) and K2CO3 (0.02 mol). The anticancer activity of the title compounds performed against T-47D, HeLa, HepG2, and MCF-7 human cancer cell lines growth was investigated by MTT assay.Results: The compounds 7b and 7g exhibited 90% of the growth inhibitory effect on T-47D, HeLa, and MCF-7 and also 80% growth inhibition in HepG2 when compared with standard drug paclitaxel.Conclusion: The synthesized compounds 4-(piperidin-1-ylmethyl)-2-(thiophen-2-yl) quinoline 7(a-j) exhibited a considerable degree of growth inhibition of human cancer cell lines. The synthesized molecules 7(a-j) are in acceptable range and are less toxic and can be considered as possible hits for drug discovery. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://journals.innovareacademics.in/index.php/ajpcr/article/view/24147/14382; https://journals.innovareacademics.in/index.php/ajpcr/article/view/24147 |
| Availability: |
https://journals.innovareacademics.in/index.php/ajpcr/article/view/24147 |
| Accession Number: |
edsbas.339E1A80 |
| Database: |
BASE |