| Title: |
Metabolic health in people living with type 1 diabetes in Belgium: a repeated cross-sectional study. |
| Authors: |
Lavens, Astrid; De Block, Christophe; Oriot, Philippe; Crenier, Laurent; Philips, Jean-Christophe; Vandenbroucke, Michel; Vanherwegen, An-Sofie; Nobels, Frank; Mathieu, Chantal; IQED Group of Experts |
| Source: |
Diabetologia (2024-09-13) |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2024 |
| Collection: |
University of Liège: ORBi (Open Repository and Bibliography) |
| Subject Terms: |
Combined metabolic abnormalities; Diabetes complications; Diabetes treatment; Metabolic health; Metabolic syndrome; Obesity; Real-world data; Type 1 diabetes; Human health sciences; Endocrinology; metabolism & nutrition; Sciences de la santé humaine; Endocrinologie; métabolisme & nutrition |
| Description: |
peer reviewed ; [en] AIMS/HYPOTHESIS: Metabolic abnormalities such as central obesity, insulin resistance, dyslipidaemia and hypertension, often referred to as 'the metabolic syndrome' (or 'combined metabolic abnormalities'), are increasingly being identified in people living with type 1 diabetes, accelerating the risk for CVD. As a result, in recent years, treatment in people living with type 1 diabetes has shifted to improving overall metabolic health rather than glucose control alone. In Belgium, diabetes care for people living with type 1 diabetes is centrally organised. The Initiative for Quality Improvement and Epidemiology in Diabetes, imposed by the Belgian health insurance system, has systematically collected data from patients on intensive insulin therapy treated in all 101 diabetes clinics in Belgium since 2001. The aim of this real-world study is to describe the evolution of treatment and metabolic health, including the prevalence of obesity and combined metabolic abnormalities, in people living with type 1 diabetes over the past 20 years, and to compare the treatment and prevalence of complications between those with and without combined metabolic abnormalities. METHODS: We analysed data on adults (≥16 years old) living with type 1 diabetes, who were diagnosed at age ≤45 years and who had a diabetes duration ≥1 year, collected between 2001 and 2022. The evolution of HbA1c, BMI, LDL-cholesterol, systolic BP, lipid-lowering therapy and antihypertensive therapy over time was analysed. The prevalence of individual and multiple metabolic abnormalities according to various definitions of the metabolic syndrome/combined metabolic abnormalities was analysed, and the association between combined metabolic abnormalities and metabolic health indicators, complications and treatment was investigated in the 2022 data. RESULTS: The final dataset consisted of 26,791 registrations of adults living with type 1 diabetes collected between 2001 and 2022. Although glycaemic and lipid control generally improved over time, ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0012-186X; 1432-0428 |
| Relation: |
https://link.springer.com/content/pdf/10.1007/s00125-024-06273-7.pdf; urn:issn:0012-186X; urn:issn:1432-0428; https://orbi.uliege.be/handle/2268/322032; info:hdl:2268/322032; info:pmid:39271516 |
| DOI: |
10.1007/s00125-024-06273-7 |
| Availability: |
https://orbi.uliege.be/handle/2268/322032; https://orbi.uliege.be/bitstream/2268/322032/1/s00125-024-06273-7.pdf; https://doi.org/10.1007/s00125-024-06273-7 |
| Rights: |
open access ; http://purl.org/coar/access_right/c_abf2 ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.33F30D2D |
| Database: |
BASE |