| Title: |
Efavirenz-based highly active antiretroviral therapy disrupts folliculogenesis: evidence from 48 women of reproductive age |
| Authors: |
Ohihoin, Aigbe G; Ogbeifun, Henry E; Ohihoin, Esther; Bakare, Airat; Mbarie, Imuwahen; Herbertson, Ebiere; Oladele, David; Omololu, Olufemi M; Cole, Osagie; Ohihoin, Vahe; Wapmuk, Agatha; Chika, Onwuamah; Ezechi, Oliver; Salako, Babatunde L; Taylor-Robinson, Simon D |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2025 |
| Collection: |
Imperial College London: Spiral |
| Subject Terms: |
anti-retroviral drugs; folliculogenesis; hiv; reproductive age; reproductive outcome |
| Description: |
Introduction: Interventions to eliminate mother-to-child transmission of HIV have led to a low vertical transmission rate and improved reproductive outcomes for women living with HIV. There are genuine concerns about the long-term effect of antiretroviral drugs (ARVs) on the future reproductive function of females, as female rodent models have shown impaired folliculogenesis when treated with contemporary ARVs. There is a need to investigate the effect of contemporary ARVs on the ovarian reserve of patients receiving ARVs. Methods: This cross-sectional study was conducted on women between the reproductive age of 15 and 45 years, forming three study categories. Group 1 comprised HIV-positive patients already on efavirenz-based antiretroviral therapy. Group 2 comprised HIV-positive patients who were naïve to ARVs at the time of recruitment. Group 3 comprised HIV-negative women within the reproductive age range not on ARVs (controls). We used t-test and ANOVA for statistical analysis. The alpha level was significant if the p-value was |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Cureus; Cureus, 2025, 17 (2); https://hdl.handle.net/10044/1/118129; https://www.dx.doi.org/10.7759/cureus.79597; https://doi.org/10.7759/cureus.79597 |
| DOI: |
10.7759/cureus.79597 |
| Availability: |
https://hdl.handle.net/10044/1/118129; https://doi.org/10.7759/cureus.79597 |
| Rights: |
© Copyright 2025 Ohihoin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.3404F985 |
| Database: |
BASE |