| Title: |
Phosphoinositide signaling in the nucleus: Impacts on chromatin and transcription regulation |
| Authors: |
Hifdi, Nesrine; Vaucourt, Mathilde; Hnia, Karim; Panasyuk, Ganna; Vandromme, Marie |
| Contributors: |
Institut des Maladies Métaboliques et Casdiovasculaires (UPS/Inserm U1297 - I2MC); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Toulouse (EPE UT); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse) |
| Source: |
ISSN: 0248-4900. |
| Publisher Information: |
CCSD; Wiley |
| Publication Year: |
2024 |
| Collection: |
Université Toulouse III - Paul Sabatier: HAL-UPS |
| Subject Terms: |
Phosphoinositides; Nucleus; Muscle; Epigenetics; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Phosphoinositides also called Polyphosphoinositides (PPIns) are small lipid messengers with established key roles in organelle trafficking and cell signaling in response to physiological and environmental inputs. Besides their well‐described functions in the cytoplasm, accumulating evidences pointed to PPIns involvement in transcription and chromatin regulation. Through the description of previous and recent advances of PPIns implication in transcription, this review highlights key discoveries on how PPIns modulate nuclear factors activity and might impact chromatin to modify gene expression. Finally, we discuss how PPIns nuclear and cytosolic metabolisms work jointly in orchestrating key transduction cascades that end in the nucleus to modulate gene expression. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39707648; PUBMED: 39707648; PUBMEDCENTRAL: PMC11771838 |
| DOI: |
10.1111/boc.202400096 |
| Availability: |
https://inserm.hal.science/inserm-05456241; https://inserm.hal.science/inserm-05456241v1/document; https://inserm.hal.science/inserm-05456241v1/file/Biology%20of%20the%20Cell%20-%202024%20-%20Hifdi.pdf; https://doi.org/10.1111/boc.202400096 |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.341F1899 |
| Database: |
BASE |