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Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals

Title:	Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals
Authors:	Dastani, Zari; Hivert, Marie-France; Timpson, Nicholas; Perry, John R. B.; Yuan, Xin; Scott, Robert A.; Henneman, Peter; Heid, Iris M.; Kizer, Jorge R.; LyytikÃ¤inen, Leo-Pekka; Fuchsberger, Christian; Tanaka, Toshiko; Morris, Andrew P.; Small, Kerrin; Isaacs, Aaron; Beekman, Marian; Coassin, Stefan; Lohman, Kurt; Qi, Lu; Kanoni, Stavroula; Pankow, James S.; Uh, Hae-Won; Wu, Ying; Bidulescu, Aurelian; Rasmussen-Torvik, Laura J.; Greenwood, Celia M. T.; Ladouceur, Martin; Grimsby, Jonna; Manning, Alisa K.; Liu, Ching-Ti; Kooner, Jaspal; Mooser, Vincent E.; Vollenweider, Peter; Kapur, Karen A.; Chambers, John; Wareham, Nicholas J.; Langenberg, Claudia; Frants, Rune; Willems-VanDijk, Ko; Oostra, Ben A.; Willems, Sara M.; Lamina, Claudia; Winkler, Thomas W.; Psaty, Bruce M.; Tracy, Russell P.; Brody, Jennifer; Chen, Ida; Viikari, Jorma; KÃ¤hÃ¶nen, Mika; Pramstaller, Peter P.; Evans, David M.; S.t. Pourcain, Beate; Sattar, Naveed; Wood, Andrew R.; Bandinelli, Stefania; Carlson, Olga D.; Egan, Josephine M.; BÃ¶hringer, Stefan; van Heemst, Diana; Kedenko, Lyudmyla; Kristiansson, Kati; Nuotio, Marja-Liisa; Loo, Britt-Marie; Harris, Tamara; Garcia, Melissa; Kanaya, Alka; Haun, Margot; Klopp, Norman; Wichmann, H. -Erich; Deloukas, Panos; Katsareli, Efi; Couper, David J.; Duncan, Bruce B.; Kloppenburg, Margreet; Adair, Linda S.; Borja, Judith B.; DIAGRAM+ Consortium, null; MAGIC Consortium, null; GLGC Investigators, null; MuTHER Consortium, null; Wilson, James G.; Musani, Solomon; Guo, Xiuqing; Johnson, Toby; Semple, Robert; Teslovich, Tanya M.; Allison, Matthew A.; Redline, Susan; Buxbaum, Sarah G.; Mohlke, Karen L.; Meulenbelt, Ingrid; Ballantyne, Christie M.; Dedoussis, George V.; Hu, Frank B.; Liu, Yongmei; Paulweber, Bernhard; Spector, Timothy D.; Slagboom, P. Eline; Ferrucci, Luigi; Jula, Antti; Perola, Markus; Raitakari, Olli; Florez, Jose C.; Salomaa, Veikko; Eriksson, Johan G.; Frayling, Timothy M.; Hicks, Andrew A.; LehtimÃ¤ki, Terho; Smith, George Davey; Siscovick, David S.; Kronenberg, Florian; van Duijn, Cornelia; Loos, Ruth J. F.; Waterworth, Dawn M.; Meigs, James B.; Dupuis, Josee; Richards, J. Brent; Voight, Benjamin F.; Scott, Laura J.; Steinthorsdottir, Valgerdur; Dina, Christian; Welch, Ryan P.; Zeggini, Eleftheria; Huth, Cornelia; Aulchenko, Yurii S.; Thorleifsson, Gudmar; McCulloch, Laura J.; Ferreira, Teresa; Grallert, Harald; Amin, Najaf; Wu, Guanming; Willer, Cristen J.; Raychaudhuri, Soumya; McCarroll, Steve A.; Hofmann, Oliver M.; Dupuis, JosÃ©e; SegrÃ, Ayellet V.; van Hoek, Mandy; Navarro, Pau; Ardlie, Kristin; Balkau, Beverley; Benediktsson, Rafn; Bennett, Amanda J.; Blagieva, Roza; Boerwinkle, Eric; Bonnycastle, Lori L.; BostrÃ¶m, Kristina Bengtsson; Bravenboer, Bert; Bumpstead, Suzannah; Burtt, NoÃ«l P.; Charpentier, Guillaume; Chines, Peter S.; Cornelis, Marilyn; Crawford, Gabe; Doney, Alex S. F.; Elliott, Katherine S.; Elliott, Amanda L.; Erdos, Michael R.; Fox, Caroline S.; Franklin, Christopher S.; Ganser, Martha; Gieger, Christian; Grarup, Niels; Green, Todd; Griffin, Simon; Groves, Christopher J.; Guiducci, Candace; Hadjadj, Samy; Hassanali, Neelam; Herder, Christian; Isomaa, Bo; Jackson, Anne U.; Johnson, Paul R. V.; JÃ ̧rgensen, Torben; Kao, Wen H. L.; Kong, Augustine; Kraft, Peter; Kuusisto, Johanna; Lauritzen, Torsten; Li, Man; Lieverse, Aloysius; Lindgren, Cecilia M.; Lyssenko, Valeriya; Marre, Michel; Meitinger, Thomas; Midthjell, Kristian; Morken, Mario A.; Narisu, Narisu; Nilsson, Peter; Owen, Katharine R.; Payne, Felicity; Petersen, Ann-Kristin; Platou, Carl; Proenca, Christine; Prokopenko, Inga; Rathmann, Wolfgang; Rayner, N. William; Robertson, Neil R.; Rocheleau, Ghislain; Roden, Michael; Sampson, Michael J.; Saxena, Richa; Shields, Beverley M.; Shrader, Peter; Sigurdsson, Gunnar; SparsÃ ̧, Thomas; Strassburger, Klaus; Stringham, Heather M.; Sun, Qi; Swift, Amy J.; Thorand, Barbara; Tichet, Jean; Tuomi, Tiinamaija; van Dam, Rob M.; van Haeften, Timon W.; van Herpt, Thijs; van Vliet-Ostaptchouk, Jana V.; Walters, G. Bragi; Weedon, Michael N.; Wijmenga, Cisca; Witteman, Jacqueline; Bergman, Richard N.; Cauchi, Stephane; Collins, Francis S.; Gloyn, Anna L.; Gyllensten, Ulf; Hansen, Torben; Hide, Winston A.; Hitman, Graham A.; Hofman, Albert; Hunter, David J.; Hveem, Kristian; Laakso, Markku; Morris, Andrew D.; Palmer, Colin N. A.; Rudan, Igor; Sijbrands, Eric; Stein, Lincoln D.; Tuomilehto, Jaakko; Uitterlinden, Andre; Walker, Mark; Watanabe, Richard M.; Abecasis, Goncalo R.; Boehm, Bernhard O.; Campbell, Harry; Hattersley, Andrew T.; Pedersen, Oluf; Barroso, InÃas; Groop, Leif; Sladek, Rob; Thorsteinsdottir, Unnur; Wilson, James F.; Illig, Thomas; Froguel, Philippe; van Duijn, Cornelia M.; Stefansson, Kari; Altshuler, David; Boehnke, Michael; McCarthy, Mark I.; David, T.; Soranzo, Nicole; Wheeler, Eleanor; Glazer, Nicole L.; Bouatia-Naji, Nabila; Lindgren, Cecilia M; MÃ¤gi, Reedik; Randall, Joshua; Elliott, Paul; Rybin, Denis; Dehghan, Abbas; Hottenga, Jouke Jan; Song, Kijoung; Goel, Anuj; Lajunen, Taina; Doney, Alex; Cavalcanti-ProenÃ§a, Christine; Kumari, Meena; Timpson, Nicholas J.; Zabena, Carina; Ingelsson, Erik; An, Ping; O'Connell, Jeffrey; Luan, Jianâ€TMan; Elliott, Amanda; McCarroll, Steven A.; Roccasecca, Rosa Maria; Pattou, FranÃ§ois; Sethupathy, Praveen; Ariyurek, Yavuz; Barter, Philip; Beilby, John P.; Ben-Shlomo, Yoav; Bergmann, Sven; Bochud, Murielle; Bonnefond, AmÃ©lie; Borch-Johnsen, Knut; BÃ¶ttcher, Yvonne; Brunner, Eric; Bumpstead, Suzannah J.; Chen, Yii-Der Ida; Chines, Peter; Clarke, Robert; Coin, Lachlan J. M.; Cooper, Matthew N.; Crisponi, Laura; Day, Ian N. M.; de Geus, Eco J. C.; Delplanque, Jerome; Fedson, Annette C.; Fischer-Rosinsky, Antje; Forouhi, Nita G.; Franzosi, Maria Grazia; Galan, Pilar; Goodarzi, Mark O.; Graessler, JÃ1⁄4rgen; Grundy, Scott; Gwilliam, Rhian; Hallmans, GÃ¶ran; Hammond, Naomi; Han, Xijing; Hartikainen, Anna-Liisa; Hayward, Caroline; Heath, Simon C.; Hercberg, Serge; Hillman, David R.; Hingorani, Aroon D.; Hui, Jennie; Hung, Joe; Kaakinen, Marika; Kaprio, Jaakko; Kesaniemi, Y. Antero; Kivimaki, Mika; Knight, Beatrice; Koskinen, Seppo; Kovacs, Peter; Kyvik, Kirsten Ohm; Lathrop, GMark; Lawlor, Debbie A.; Bacquer, Olivier Le; Lecoeur, CÃ©cile; Li, Yun; Mahley, Robert; Mangino, Massimo; MartÃnez-Larrad, MarÃa Teresa; McAteer, Jarred B.; McPherson, Ruth; Meisinger, Christa; Melzer, David; Meyre, David; Mitchell, Braxton D.; Mukherjee, Sutapa; Naitza, Silvia; Neville, Matthew J.; OrrÃ1, Marco; Pakyz, Ruth; Paolisso, Giuseppe; Pattaro, Cristian; Pearson, Daniel; Peden, John F.; Pedersen, Nancy L.; Pfeiffer, Andreas F. H.; Pichler, Irene; Polasek, Ozren; Posthuma, Danielle; Potter, Simon C.; Pouta, Anneli; Province, Michael A.; Rayner, Nigel W.; Rice, Kenneth; Ripatti, Samuli; Rivadeneira, Fernando; Rolandsson, Olov; Sandbaek, Annelli; Sandhu, Manjinder; Sanna, Serena; Sayer, Avan Aihie; Scheet, Paul; Seedorf, Udo; Sharp, Stephen J.; Shields, Beverley; SigurÃ°sson, Gunnar; Sijbrands, Eric J. G.; Silveira, Angela; Simpson, Laila; Singleton, Andrew; Smith, Nicholas L.; Sovio, Ulla; Swift, Amy; Syddall, Holly; SyvÃ¤nen, Ann-Christine; TÃ¶njes, Anke; Uitterlinden, AndrÃ© G.; van Dijk, Ko Willems; Varma, Dhiraj; Visvikis-Siest, Sophie; Vitart, Veronique; Vogelzangs, Nicole; Waeber, GÃ©rard; Wagner, Peter J.; Walley, Andrew; Walters, GBragi; Ward, Kim L.; Watkins, Hugh; Wild, Sarah H.; Willemsen, Gonneke; Yarnell, John W. G.; Zelenika, Diana; Zethelius, BjÃ¶rn; Zhao, Jing Hua; Zillikens, M. Carola; Abecasis, GonÃ§alo R.; Borecki, Ingrid B; Meneton, Pierre; Magnusson, Patrik K. E.; Nathan, David M.; Williams, Gordon H; Rader, Daniel J.; Silander, Kaisa; Bornstein, Stefan R; Schwarz, Peter; Spranger, Joachim; Karpe, Fredrik; Shuldiner, Alan R; Cooper, Cyrus; Dedoussis, George V; Serrano-RÃos, Manuel; Lind, Lars; Palmer, Lyle J; Hu, Frank B; Franks, Paul W.; Ebrahim, Shah; Marmot, Michael; Kao, W. H. Linda; Sampson, Michael J; Pramstaller, Peter Paul; Wichmann, H. Erich; Wright, Alan F; Stumvoll, Michael; Hamsten, Anders; Buchanan, Thomas A; Valle, Timo T.; Rotter, Jerome I; Penninx, Brenda W. J. H.; Boomsma, Dorret I.; Cao, Antonio; Scuteri, Angelo; Schlessinger, David; Uda, Manuela; Ruokonen, Aimo; Jarvelin, Marjo-Riitta; Peltonen, Leena; Mooser, Vincent; Sladek, Robert; Smith, Albert V.; Edmondson, Andrew C.; Stylianou, Ioannis M.; Koseki, Masahiro; Pirruccello, James P.; Chasman, Daniel I.; Johansen, Christopher T.; Fouchier, Sigrid W.; Peloso, Gina M.; Barbalic, Maja; Ricketts, Sally L.; Bis, Joshua C.; Feitosa, Mary F.; Orho-Melander, Marju; Melander, Olle; Li, Xiaohui; Li, Mingyao; Cho, Yoon Shin; Go, Min Jin; Kim, Young Jin; Lee, Jong-Young; Park, Taesung; Kim, Kyunga; Sim, Xueling; Ong, Rick Twee-Hee; Croteau-Chonka, Damien C.; Lange, Leslie A.; Smith, Joshua D.; Ziegler, Andreas; Zhang, Weihua; Zee, Robert Y. L.; Wright, Alan F.; Witteman, Jacqueline C. M.; Whitfield, John B.; Uitterlinden, Andre G.; Thompson, John R.; Surakka, Ida; Spector, Tim D.; Smit, Johannes H.; Sinisalo, Juha; Scott, James; Saharinen, Juha; Sabatti, Chiara; Rose, Lynda M.; Roberts, Robert; Rieder, Mark; Parker, Alex N.; Pare, Guillaume; Oâ€TMDonnell, Christopher J.; Nieminen, Markku S.; Nickerson, Deborah A.; Montgomery, Grant W.; McArdle, Wendy; Masson, David; Martin, Nicholas G.; Marroni, Fabio; Lucas, Gavin; Luben, Robert; Lokki, Marja-Liisa; Lettre, Guillaume; Launer, Lenore J.; Lakatta, Edward G.; Laaksonen, Reijo; Kyvik, Kirsten O.; KÃ¶nig, Inke R.; Khaw, Kay-Tee; Kaplan, Lee M.; Johansson, Ã.sa; Janssens, A. Cecile W.; Igl, Wilmar; Hovingh, G. Kees; Hottenga, Jouke-Jan; Hengstenberg, Christian; Havulinna, Aki S.; Hastie, Nicholas D.; Harris, Tamara B.; Haritunians, Talin; Hall, Alistair S.; Groop, Leif C.; Gonzalez, Elena; Freimer, Nelson B.; Erdmann, Jeanette; Ejebe, Kenechi G.; DÃ¶ring, Angela; Dominiczak, Anna F.; Demissie, Serkalem; Deloukas, Panagiotis; de Faire, Ulf; Crawford, Gabriel; Caulfield, Mark J.; Chen, Yii-Der I.; Burtt, Noel P.; Boekholdt, S. Matthijs; Assimes, Themistocles L.; Quertermous, Thomas; Seielstad, Mark; Wong, Tien Y.; Tai, E-Shyong; Feranil, Alan B.; Kuzawa, Christopher W.; Taylor, Herman A.; Borecki, Ingrid B.; Gabriel, Stacey B.; Holm, Hilma; Gudnason, Vilmundur; Krauss, Ronald M.; Ordovas, Jose M.; Munroe, Patricia B.; Kooner, Jaspal S.; Tall, Alan R.; Hegele, Robert A.; Kastelein, John J. P.; Schadt, Eric E.; Rotter, Jerome I.; Strachan, David P.; Reilly, Muredach P.; Samani, Nilesh J; Schunkert, Heribert; Cupples, L. Adrienne; Sandhu, Manjinder S.; Ridker, PaulM
Contributors:	Dastani, Zari; Hivert, Marie-France; Timpson, Nichola; Perry, John R. B.; Yuan, Xin; Scott, Robert A.; Henneman, Peter; Heid, Iris M.; Kizer, Jorge R.; Lyytikã¤inen, Leo-Pekka; Fuchsberger, Christian; Tanaka, Toshiko; Morris, Andrew P.; Small, Kerrin; Isaacs, Aaron; Beekman, Marian; Coassin, Stefan; Lohman, Kurt; Qi, Lu; Kanoni, Stavroula; Pankow, James S.; Uh, Hae-Won; Wu, Ying; Bidulescu, Aurelian; Rasmussen-Torvik, Laura J.; Greenwood, Celia M. T.; Ladouceur, Martin; Grimsby, Jonna; Manning, Alisa K.; Liu, Ching-Ti; Kooner, Jaspal; Mooser, Vincent E.; Vollenweider, Peter; Kapur, Karen A.; Chambers, John; Wareham, Nicholas J.; Langenberg, Claudia; Frants, Rune; Willems-VanDijk, Ko; Oostra, Ben A.; Willems, Sara M.; Lamina, Claudia; Winkler, Thomas W.; Psaty, Bruce M.; Tracy, Russell P.; Brody, Jennifer; Chen, Ida; Viikari, Jorma; Kã¤hã¶nen, Mika; Pramstaller, Peter P.; Evans, David M.; S. t. Pourcain, Beate; Sattar, Naveed; Wood, Andrew R.; Bandinelli, Stefania; Carlson, Olga D.; Egan, Josephine M.; Bã¶hringer, Stefan; van Heemst, Diana; Kedenko, Lyudmyla; Kristiansson, Kati; Nuotio, Marja-Liisa; Loo, Britt-Marie; Harris, Tamara; Garcia, Melissa; Kanaya, Alka; Haun, Margot; Klopp, Norman; Wichmann, H. -Erich; Deloukas, Pano; Katsareli, Efi; Couper, David J.; Duncan, Bruce B.; Kloppenburg, Margreet; Adair, Linda S.; Borja, Judith B.; DIAGRAM+ Consortium, Null; MAGIC Consortium, Null; GLGC Investigators, Null; MuTHER Consortium, Null; Wilson, James G.; Musani, Solomon; Guo, Xiuqing; Johnson, Toby; Semple, Robert; Teslovich, Tanya M.; Allison, Matthew A.; Redline, Susan; Buxbaum, Sarah G.; Mohlke, Karen L.; Meulenbelt, Ingrid; Ballantyne, Christie M.; Dedoussis, George V.; Hu, Frank B.; Liu, Yongmei; Paulweber, Bernhard; Spector, Timothy D.; Slagboom, P. Eline; Ferrucci, Luigi; Jula, Antti
Publication Year:	2012
Collection:	Università degli Studi di Cagliari: UNICA IRIS
Subject Terms:	Adiponectin; African American; Asian Continental Ancestry Group; Cholesterol; HDL; Diabetes Mellitus; Type 2; European Continental Ancestry Group; Female; Gene Expression; Genetic Predisposition to Disease; Glucose Tolerance Test; Human; Insulin Resistance; Male; Metabolic Networks and Pathway; Polymorphism; Single Nucleotide; Waist-Hip Ratio; Genome-Wide Association Study; Ecology; Evolution; Behavior and Systematic; Molecular Biology; Genetic; Genetics (clinical); Cancer Research
Description:	Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5Ã—10âˆ’8- 1.2 Ã—10âˆ’43). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p
Document Type:	article in journal/newspaper
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/22479202; info:eu-repo/semantics/altIdentifier/wos/WOS:000302254800080; volume:8; issue:3; numberofpages:23; journal:PLOS GENETICS; https://hdl.handle.net/11584/231374
DOI:	10.1371/journal.pgen.1002607
Availability:	https://hdl.handle.net/11584/231374; https://doi.org/10.1371/journal.pgen.1002607; http://genetics.plosjournals.org/perlserv/?request=get-archive&issn=1553-7404
Rights:	info:eu-repo/semantics/openAccess
Accession Number:	edsbas.3475AF9F
Database:	BASE