| Title: |
Association Between Colorectal Cancer Screening and Survival in Patients Older Than 70 Years: Results of A National Multicenter Retrospective Study |
| Authors: |
Rottoli, Matteo; Calini, Giacomo; Castagna, Giovanni; Gori, Alice; Cardelli, Stefano; Spinelli, Antonino; Pellino, Gianluca; Bianconi, Alessandro; Fiore, Matteo; Rosati, Riccardo; Morino, Mario; de Manzini, Nicolò; Pietrabissa, Andrea; Boni, Luigi; Poggioli, Gilberto; Tiberio, Guido A. M. |
| Contributors: |
Rottoli Matteo; Calini Giacomo; Castagna Giovanni; Gori Alice; Cardelli Stefano; Spinelli Antonino; Pellino Gianluca; Bianconi Alessandro; Fiore Matteo; Rosati Riccardo; Morino Mario; De Manzini Nicolò; Pietrabissa Andrea; Boni Luigi; Poggioli Gilberto; Tiberio Guido A. M. |
| Publication Year: |
2026 |
| Collection: |
Università degli Studi di Brescia: OPENBS - Open Archive UniBS |
| Subject Terms: |
colorectal cancer; over 70 years old; screening; survival |
| Description: |
Background: Colorectal cancer screening mainly targets a population between 50 and 70 years of age; however, it is inconsistently implemented in people over 70. The aim of this study was to analyze the association between colorectal cancer (CRC) screening, postoperative mortality, and perioperative and oncologic outcomes in a large population of patients over 70 years of age who underwent surgery for CRC. Methods: Data regarding people over 70 who underwent CRC surgery were retrieved from a nationally validated retrospective database, including four consecutive years (2018-2021) and 81 centers. The patients were divided into two groups according to their participation in the CRC screening program: Screening versus No Screening. The outcomes of the study were 30-day mortality; urgent, palliative and minimally invasive surgery rates; Clavien-Dindo ≥ III; advanced oncologic stage; R0 resection and length of hospital stay (LOS). Logistic regression analysis was carried out and adjusted for multiple confounders. Results: Of the 10,346 patients over 70,676 were in the screening group, and 9670 were in the no screening group. At logistic regression, CRC screening was significantly associated with a reduction in 30-day mortality (OR 0.41, 95% CI 0.18-0.92, p = 0.032), urgent surgery (OR 0.06, 95% CI 0.02-0.14, p < 0.001), palliative surgery (OR 0.32, 95% CI 0.19-0.54, p < 0.001), Clavien-Dindo ≥ III complications (OR 0.69, 95% CI 0.51-0.93, p = 0.016) and advanced oncologic stage (OR 0.53, 95% CI 0.45-0.62, p < 0.001), and a significant increase in R0 resections (OR 3.15, 95% CI 1.67-5.94, p < 0.001) and laparoscopic surgery (OR 1.93, 95% CI 1.57-2.38, p < 0.001). The crude and adjusted Odds Ratio similarity confirmed this correlation, regardless of the comorbidities and confounders. Conclusions: Adherence to CRC screening should be further encouraged and standardized for people over 70. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41723819; journal:JOURNAL OF SURGICAL ONCOLOGY; https://hdl.handle.net/11379/640405 |
| DOI: |
10.1002/jso.70206 |
| Availability: |
https://hdl.handle.net/11379/640405; https://doi.org/10.1002/jso.70206 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:PUBBLICO - Pubblico con Copyright ; license uri:iris.PUB02 |
| Accession Number: |
edsbas.347A19AF |
| Database: |
BASE |