| Title: |
Circular RNAs: Non-Canonical Observations on Non-Canonical RNAs |
| Authors: |
Stringer, Brett W; Gantley, Laura; Conn, Simon J |
| Publisher Information: |
MDPI |
| Publication Year: |
2023 |
| Collection: |
Griffith University: Griffith Research Online |
| Subject Terms: |
Genetics; Oncology and carcinogenesis; Biological sciences; Biomedical and clinical sciences; Science & Technology; Life Sciences & Biomedicine; Cell Biology; circular RNA; circRNA |
| Description: |
The existence of circular RNA (circRNA) research in mainstream science can be attributed to the contemporary synergism of big data and keen attention to detail by several research groups worldwide. Since the re-emergence of these non-canonical RNA transcripts, seminal advances have been made in understanding their biogenesis, interactome, and functions in diverse fields and a myriad of human diseases. However, most research outputs to date have focused on the ability of highly stable circRNAs to interact with, and impact signalling through, microRNAs. This is likely to be the result of seminal papers in the field ascribing a few remarkable circRNAs as “miRNA sponges”. However, the stoichiometric ratio between the (often-lowly-expressed) circRNA and their (commonly-more-abundant) target is rarely in favour of a biologically relevant and functional consequence of these interactions. It is time for yet another revolution in circRNA research to uncover functions beyond their documented ability to bind miRNAs. This Special Issue aims to highlight non-canonical functions for this non-canonical family of RNA molecules. ; Full Text |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Cells; Stringer, BW; Gantley, L; Conn, SJ, Circular RNAs: Non-Canonical Observations on Non-Canonical RNAs, Cells, 2023, 12 (2), pp. 323; https://hdl.handle.net/10072/424986 |
| DOI: |
10.3390/cells12020323 |
| Availability: |
https://hdl.handle.net/10072/424986; https://doi.org/10.3390/cells12020323 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). ; open access |
| Accession Number: |
edsbas.347E79BF |
| Database: |
BASE |