Dieses Ergebnis aus BASE kann Gästen nicht angezeigt werden. Login für vollen Zugriff.

Genetically elevated high-density lipoprotein cholesterol through cholesteryl ester transfer protein does not associate with risk of Alzheimer's disease

Title:	Genetically elevated high-density lipoprotein cholesterol through cholesteryl ester transfer protein does not associate with risk of Alzheimer's disease
Authors:	Gina M. Pelosoa; Sven J. van der Leeb; Sims R; van der Lee SJ; Naj AC; Bellenguez C; Badarinarayan N; Jakobsdottir J; Kunkle BW; Boland A; Raybould R; Bis JC; Martin ER; Grenier-Boley B; Heilmann-Heimbach S; Chouraki V; Kuzma AB, Sleegers K; Vronskaya M; Ruiz A; Graham RR; Olaso R; Hoffmann P; Grove ML, Vardarajan BN; Hiltunen M; Nöthen MM; White CC; Hamilton-Nelson KL; Epelbaum J; Maier W; Choi SH; Beecham GW; Dulary C, Herms S; Smith AV; Funk CC; Derbois C; Forstner AJ; Ahmad S; Li H; Bacq D; Harold D; Satizabal CL; Valladares O; Squassina A; Thomas R; Brody JA; Qu L; Sánchez-Juan P; Morgan T; Wolters FJ; Zhao Y; Garcia FS; Denning N; Fornage M; Malamon J; Naranjo MCD; Majounie E; Mosley TH; Dombroski B; Wallon D; Lupton MK; Dupuis J; Whitehead P; Fratiglioni L; Medway C; Jian X; Mukherjee S; Keller L; Brown K; Lin H; Cantwell LB; Panza F; McGuinness B; Moreno-Grau S; Burgess JD; Solfrizzi V; Proitsi P; Adams HH; Allen M; Seripa D; Pastor P; Cupples LA; Price ND, Hannequin D; Frank-García A; Levy D; Chakrabarty P, Caffarra P; Giegling I, Beiser AS; Giedraitis V, Hampel H; Garcia ME; Wang X; Lannfelt L; Mecocci P; Eiriksdottir G; Crane PK; Pasquier F; Boccardi V; Henández I; Barber RC; Scherer M; Tarraga L; Adams PM; Leber M; Chen Y; Albert MS; Riedel-Heller S; Emilsson V; Beekly D; Braae A; Schmidt R; Blacker D; Masullo C; Schmidt H; Doody RS; Spalletta G; Longstreth WT Jr.; Fairchild TJ; Bossù P; Lopez OL; Frosch MP; Sacchinelli E; Ghetti B; Yang Q; Huebinger RM; Jessen F; Li S, Kamboh MI; Morris J; Sotolongo-Grau O; Katz MJ; Corcoran C; Dunstan M; Braddel A; Thomas C; Meggy A; Marshall R; Gerrish A; Chapman J; Aguilar M; Taylor S; Hill M; Fairén MD; Hodges A; Vellas B; Soininen H; Kloszewska I; Daniilidou M; Uphill J; Patel Y; Hughes JT; Lord J; Turton J; Hartmann AM; Cecchetti R; Fenoglio C; Serpente M; Arcaro M; Caltagirone C; Orfei MD; Ciaramella A; Pichler S; Mayhaus M; Gu W; Lleó A; Fortea J; Blesa R; Barber IS; Brookes K; Cupidi C; Maletta RG; Carrell D; Sorbi S; Moebus S; Urbano M; Pilotto A; Kornhuber J; Bosco P; Todd S; Craig D; Johnston J; Gill M; Lawlor B; Lynch A; Fox NC; Hardy J; ARUK Consortium, Albin RL; Apostolova LG; Arnold SE, Asthana S; Atwood CS; Baldwin CT, Barnes LL; Barral S; Beach TG; Becker JT; Bigio EH; Bird TD; Boeve BF; Bowen JD; Boxer A; Burke JR; Burns JM; Buxbaum JD; Cairns NJ; Cao C; Carlson CS; Carlsson CM; Carney RM; Carrasquillo MM; Carroll SL; Diaz CC; Chui HC; Clark DG; Cribbs DH; Crocco EA; DeCarli C; Dick M; Duara R; Evans DA; Faber KM; Fallon KB; Fardo DW; Farlow MR; Ferris S; Foroud TM; Galasko DR; Gearing M; Geschwind DH, Gilbert JR; Graff-Radford NR; Green RC; Growdon JH; Hamilton RL; Harrell LE; Honig LS; Huentelman MJ; Hulette CM; Hyman BT; Jarvik GP; Abner E; Jin LW; Jun G; Karydas A, Kaye JA; Kim R, Kowall NW; Kramer JH; LaFerla FM; Lah JJ; Leverenz JB; Levey AI; Li G; Lieberman AP; Lunetta KL; Lyketsos CG; Marson DC; Martiniuk F; Mash DC; Masliah E; McCormick WC; McCurry SM; McDavid AN; McKee AC; Mesulam M; Miller BL; Miller CA; Miller JW; Morris JC; Murrell JR; Myers AJ; O'Bryant S; Olichney JM; Pankratz VS; Parisi JE; Paulson HL; Perry W; Peskind E; Pierce A; Poon WW; Potter H; Quinn JF; Raj A; Raskind M; Reisberg B; Reitz C; Ringman JM; Roberson ED; Rogaeva E; Rosen HJ; Rosenberg RN; Sager MA; Saykin AJ; Schneider JA; Schneider LS; Seeley WW; Smith AG; Sonnen JA; Spina S; Stern RA; Swerdlow RH; Tanzi RE; Thornton-Wells TA; Trojanowski JQ; Troncoso JC; Van Deerlin VM; Van Eldik LJ; Vinters HV; Vonsattel JP, Weintraub S; Welsh-Bohmer KA; Wilhelmsen KC; Williamson J; Wingo TS; Woltjer RL; Wright CB; Yu CE; Yu L; Garzia F; Golamaully F; Septier G; Engelborghs S; Vandenberghe R; De Deyn PP; Fernadez CM; Benito YA; Thonberg H; Forsell C; Lilius L; Kinhult-Stählbom A; Kilander L; Brundin R; Concari L; Helisalmi S; Koivisto AM; Haapasalo A; Dermecourt V, Fievet N; Hanon O, Dufouil C; Brice A; Ritchie K, Dubois B; Himali JJ; Keene CD; Tschanz J; Fitzpatrick AL; Kukull WA; Norton M; Aspelund T; Larson EB; Munger R; Rotter JI; Lipton RB; Bullido MJ; Hofman A; Montine TJ; Coto E; Boerwinkle E; Petersen RC; Alvarez V; Rivadeneira F; Reiman EM; Gallo M; O'Donnell CJ; Reisch JS; Bruni AC; Royall DR; Dichgans M; Sano M; Galimberti D; St George-Hyslop P; Scarpini E, Tsuang DW; Mancuso M; Bonuccelli U; Winslow AR; Daniele A; Wu CK; GERAD/PERADES CHARGE; ADGC EADI; Peters O; Nacmias B; Riemenschneider M; Heun R; Brayne C; Rubinsztein DC; Bras J; Guerreiro R; Al-Chalabi A; Shaw CE; Collinge J; Mann D; Tsolaki M; Clarimón J; Sussams R; Lovestone S; O'Donovan MC; Owen MJ; Behrens TW; Mead S; Goate AM; Uitterlinden AG; Holmes C, Cruchaga C; Ingelsson M, Bennett DA; Powell J, Golde TE; Graff C; De Jager PL; Morgan K; Ertekin-Taner N; Combarros O, Psaty BM; Passmore P, Younkin SG; Berr C; Gudnason V; Rujescu D; Dickson DW; Dartigues JF; DeStefano AL; Ortega-Cubero S; Hakonarson H, Campion D; Boada M; Kauwe JK; Farrer LA; Van Broeckhoven C; Ikram MA; Jones L; Haines JL; Tzourio C; Launer LJ; Escott-Price V; Mayeux R; Deleuze JF; Amin N; Holmans PA; Pericak-Vance MA; Amouyel P; van Duijn CM, Ramirez A; Wang LS, Lambert JC; Seshadri S; Williams J; Schellenberg GD.; Anita L. Destefanoa; Sudha Seshardi
Contributors:	Gina M., Pelosoa; Sven J., van der Leeb; Sims, R; van der Lee, Sj; Naj, Ac; Bellenguez, C; Badarinarayan, N; Jakobsdottir, J; Kunkle, Bw; Boland, A; Raybould, R; Bis, Jc; Martin, Er; Grenier-Boley, B; Heilmann-Heimbach, S; Chouraki, V; Kuzma AB, Sleegers K; Vronskaya, M; Ruiz, A; Graham, Rr; Olaso, R; Hoffmann, P; Grove ML, Vardarajan BN; Hiltunen, M; Nöthen, Mm; White, Cc; Hamilton-Nelson, Kl; Epelbaum, J; Maier, W; Choi, Sh; Beecham, Gw; Dulary C, Herms S; Smith, Av; Funk, Cc; Derbois, C; Forstner, Aj; Ahmad, S; Li, H; Bacq, D; Harold, D; Satizabal, Cl; Valladares, O; Squassina, A; Thomas, R; Brody, Ja; Qu, L; Sánchez-Juan, P; Morgan, T; Wolters, Fj; Zhao, Y; Garcia, F; Denning, N; Fornage, M; Malamon, J; Naranjo, Mcd; Majounie, E; Mosley, Th; Dombroski, B; Wallon, D; Lupton, Mk; Dupuis, J; Whitehead, P; Fratiglioni, L; Medway, C; Jian, X; Mukherjee, S; Keller, L; Brown, K; Lin, H; Cantwell, Lb; Panza, F; Mcguinness, B; Moreno-Grau, S; Burgess, Jd; Solfrizzi, V; Proitsi, P; Adams, Hh; Allen, M; Seripa, D; Pastor, P; Cupples, La; Price ND, Hannequin D; Frank-García, A; Levy, D; Chakrabarty P, Caffarra P; Giegling I, Beiser AS; Giedraitis V, Hampel H; Garcia, Me; Wang, X; Lannfelt, L; Mecocci, P; Eiriksdottir, G; Crane, Pk; Pasquier, F; Boccardi, V; Henández, I; Barber, Rc; Scherer, M; Tarraga, L; Adams, Pm
Publication Year:	2018
Collection:	Università degli Studi di Cagliari: UNICA IRIS
Description:	Introduction: There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered HDL-C. We aimed to assess AD risk by genetically predicted HDL-C. Methods: Ten single nucleotide polymorphisms within the CETP locus predicting HDL-C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR-Egger. Results: Based on 10 single nucleotide polymorphisms distinctly predicting HDL-C in the CETP locus, we found that HDL-C was not associated with risk of AD (P >.7). Discussion: Our study does not support the role of HDL-C on risk of AD through HDL-C altered by CETP. This study does not rule out other mechanisms by which HDL-C affects risk of AD.
Document Type:	article in journal/newspaper
Language:	English
Relation:	volume:10; firstpage:595; lastpage:598; numberofpages:4; journal:ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING; https://hdl.handle.net/11584/252194
DOI:	10.1016/j.dadm.2018.08.008
Availability:	https://hdl.handle.net/11584/252194; https://doi.org/10.1016/j.dadm.2018.08.008
Rights:	info:eu-repo/semantics/openAccess
Accession Number:	edsbas.34870C31
Database:	BASE