| Title: |
Unveiling Pathological Insights and Accelerating Antiviral Drug Discovery inRespiratory Viral Infections with Polarized Organoids |
| Authors: |
Alessandri-Gradt, Elodie; Hubert, Mathieu; Archambault, Flora; Tombette, Fabienne; Cambet, Yves; Constant, Samuel; Ar Gouilh, Meriadeg, M.; Plantier, Jean-Christophe; Benard, Magalie; Galas, Ludovic; Tapparel, Caroline |
| Contributors: |
Dynamique Microbienne associée aux Infections Urinaires et Respiratoires (DYNAMICURE); Université de Caen Normandie (UNICAEN); Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN); Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM); Service de Virologie CHU Caen; CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie (CHU Caen Normandie); Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN); Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0); Normandie Université (NU) |
| Source: |
THE THIRD P2M ROUEN INTERNATIONAL SYMPOSIUM -Pathways to PRECISION MEDECINE ; https://hal.science/hal-05065776 ; THE THIRD P2M ROUEN INTERNATIONAL SYMPOSIUM -Pathways to PRECISION MEDECINE, Apr 2025, Rouen, France |
| Publisher Information: |
CCSD |
| Publication Year: |
2025 |
| Collection: |
Normandie Université: HAL |
| Subject Terms: |
Precision medicine; Organoids; [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract; [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology |
| Subject Geographic: |
Rouen; France |
| Description: |
International audience ; Over the past decade, organoid models have not only emerged as an innovative research model but also as a valuable tool in precision medicine, particularly in the field of respiratory diseases. These three-dimensional in vitro models can replicate the complex architecture of human tissues, providing opportunities to predict drug response. This is especially critical in the context of respiratory viruses for which effective antiviral treatments are often lacking. Moreover, respiratory organoids generated from individual human primary cells could revolutionize our understanding of pulmonary diseases like asthma, chronic obstructive pulmonary disease (COPD), or cystic fibrosis (CF).This work aims to explore the role of respiratory organoids in precision medicine, focusing on their application in studying viral respiratory infection and their potential to personalize treatment approaches for patients. |
| Document Type: |
conference object; still image |
| Language: |
English |
| Availability: |
https://hal.science/hal-05065776; https://hal.science/hal-05065776v1/document; https://hal.science/hal-05065776v1/file/P2M2025_Poster_organoids_20250307.pdf |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.34AA907C |
| Database: |
BASE |