| Title: |
Procalcitonin is not a reliable biomarker of bacterial coinfection in people with coronavirus disease 2019 undergoing microbiological investigation at the time of hospital admission |
| Authors: |
Relph, KA; Russell, CD; Fairfield, CJ; Turtle, L; de Silva, TI; Siggins, MK; Drake, TM; Thwaites, RS; Abrams, S; Moore, SC; Hardwick, HE; Oosthuyzen, W; Harrison, EM; Docherty, AB; Openshaw, PJM; Baillie, JK; Semple, MG; Ho, A; Carson, G; Alex, B; Bach, B; Barclay, WS; Bogaert, D; Chand, M; Cooke, GS; Dunning, J; Filipe, ADS; Fletcher, T; Green, CA; Hiscox, JA; Ho, AYW; Horby, PW; Ijaz, S; Khoo, S; Klenerman, P; Law, A; Lim, WS; Mentzer, AJ; Merson, L; Meynert, AM; Noursadeghi, M; Palmarini, M; Paxton, WA; Pollakis, G; Price, N; Rambaut, A; Robertson, DL; Sancho-Shimizu, V; Scott, JT; de Silva, T; Sigfrid, L; Solomon, T; Sriskandan, S; Stuart, D; Summers, C; Tedder, RS; Thomson, EC; Roger Thompson, AA; Turtle, LCW; Gupta, RK; Zambon, M; Hardwick, H; Donohue, C; Lyons, R; Griffiths, F; Norman, L; Pius, R; Knight, SR; Mclean, KA; Murphy, D; Shaw, CA; Dalton, J; Girvan, M; Saviciute, E; Roberts, S; Harrison, J; Marsh, L; Connor, M; Halpin, S; Jackson, C; Gamble, C; Leeming, G; Wham, M; Clohisey, S; Hendry, R; Scott-Brown, J; Greenhalf, W; Shaw, V; McDonald, S; Keating, S; Ahmed, KA; Armstrong, JA; Ashworth, M; Asiimwe, IG; Bakshi, S; Barlow, SL; Booth, L; Brennan, B; Bullock, K; Catterall, BWA; Clark, JJ; Clarke, EA; Cole, S; Cooper, L; Cox, H; Davis, C; Dincarslan, O; Dunn, C; Dyer, P; Elliott, A; Evans, A; Finch, L; Fisher, LWS; Foster, T; Garcia-Dorival, I; Gunning, P; Hartley, C; Jensen, RL; Jones, CB; Jones, TR; Khandaker, S; King, K; Kiy, RT; Koukorava, C; Lake, A; Lant, S; Latawiec, D; Lavelle-Langham, L; Lefteri, D; Lett, L; Livoti, LA; Mancini, M; McEvoy, L; McLauchlan, J; Metelmann, S; Miah, NS; Middleton, J; Mitchell, J; Murphy, EG; Penrice-Randal, R; Pilgrim, J; Prince, T; Reynolds, W; Matthew Ridley, P; Sales, D; Shaw, VE; Shears, RK; Small, B; Subramaniam, KS; Szemiel, A; Taggart, A; Tanianis-Hughes, J; Thomas, J; Trochu, E; van Tonder, L; Wilcock, E; Eunice Zhang, J; Flaherty, L; Maziere, N; Cass, E; Doce Carracedo, A; Carlucci, N; Holmes, A; Massey, H; Murphy, L; Wrobel, N; McCafferty, S; Morrice, K; MacLean, A; Adeniji, K; Agranoff, D; Agwuh, K; Ail, D; Aldera, EL; Alegria, A; Angus, B; Ashish, A; Atkinson, D; Bari, S; Barlow, G; Barnass, S; Barrett, N; Bassford, C; Basude, S; Baxter, D; Beadsworth, M; Bernatoniene, J; Berridge, J; Best, N; Bothma, P; Chadwick, D; Brittain-Long, R; Bulteel, N; Burden, T; Burtenshaw, A; Caruth, V; Chambler, D; Chee, N; Child, J; Chukkambotla, S; Clark, T; Collini, P; Cosgrove, C; Cupitt, J; Cutino-Moguel, M-T; Dark, P; Dawson, C; Dervisevic, S; Donnison, P; Douthwaite, S; DuRand, I; Dushianthan, A; Dyer, T; Evans, C; Eziefula, C; Fegan, C; Finn, A; Fullerton, D; Garg, S; Garg, A; Gkrania-Klotsas, E; Godden, J; Goldsmith, A; Graham, C; Hardy, E; Hartshorn, S; Harvey, D; Havalda, P; Hawcutt, DB; Hobrok, M; Hodgson, L; Hormis, A; Jacobs, M; Jain, S; Jennings, P; Kaliappan, A; Kasipandian, V; Kegg, S; Kelsey, M; Kendall, J; Kerrison, C; Kerslake, I; Koch, O; Koduri, G; Koshy, G; Laha, S; Laird, S; Larkin, S; Leiner, T; Lillie, P; Limb, J; Linnett, V; Little, J; Lyttle, M; MacMahon, M; MacNaughton, E; Mankregod, R; Masson, H; Matovu, E; McCullough, K; McEwen, R; Meda, M; Mills, G; Minton, J; Mirfenderesky, M; Mohandas, K; Mok, Q; Moon, J; Moore, E; Morgan, P; Morris, C; Mortimore, K; Moses, S; Mpenge, M; Mulla, R; Murphy, M; Nagel, M; Nagarajan, T; Nelson, M; O’Shea, MK; Otahal, I; Ostermann, M; Pais, M; Panchatsharam, S; Papakonstantinou, D; Paraiso, H; Patel, B; Pattison, N; Pepperell, J; Peters, M; Phull, M; Pintus, S; Pooni, JS; Post, F; Price, D; Prout, R; Rae, N; Reschreiter, H; Reynolds, T; Richardson, N; Roberts, M; Roberts, D; Rose, A; Rousseau, G; Ryan, B; Saluja, T; Shah, A; Shanmuga, P; Sharma, A; Shawcross, A; Sizer, J; Shankar-Hari, M; Smith, R; Snelson, C; Spittle, N; Staines, N; Stambach, T; Stewart, R; Subudhi, P; Szakmany, T; Tatham, K; Thompson, C; Thompson, R; Tridente, A; Tupper-Carey, D; Twagira, M; Ustianowski, A; Vallotton, N; Vincent-Smith, L; Visuvanathan, S; Vuylsteke, A; Waddy, S; Wake, R; Walden, A; Welters, I; Whitehouse, T; Whittaker, P; Whittington, A; Papineni, P; Wijesinghe, M; Williams, M; Wilson, L; Winchester, S; Wiselka, M; Wolverson, A; Wootton, DG; Workman, A; Yates, B; Young, P |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2022 |
| Collection: |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
| Description: |
Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11–1.70] ng/mL vs 0.24 [0.10–0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51–.60]). |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://eprints.whiterose.ac.uk/id/eprint/187366/1/ofac179.pdf; Relph, KA, Russell, CD, Fairfield, CJ et al. (365 more authors) (2022) Procalcitonin is not a reliable biomarker of bacterial coinfection in people with coronavirus disease 2019 undergoing microbiological investigation at the time of hospital admission. Open Forum Infectious Diseases, 9 (5). ofac179. |
| Availability: |
https://eprints.whiterose.ac.uk/id/eprint/187366/; https://eprints.whiterose.ac.uk/id/eprint/187366/1/ofac179.pdf |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.34BA5D7E |
| Database: |
BASE |