| Title: |
Serum persistent organic pollutants and diminished ovarian reserve: a single-exposure and mixture exposure approach from a French case-control study |
| Authors: |
Genard-Walton, M.; Warembourg, C; Duros, S.; Mercier, Fabien; Lefebvre, T; Guivarc'H-Leveque, A.; Le Martelot, M. -T.; Le Bot, B.; Jacquemin, B.; Chevrier, C; Cordier, S.; Costet, N; Multigner, L.; Garlantezec, R. |
| Contributors: |
Institut de recherche en santé, environnement et travail (Irset); Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique); École des Hautes Études en Santé Publique EHESP (EHESP); Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou; Laboratoire d'étude et de recherche en environnement et santé (LERES); Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes); Clinique mutualiste La Sagesse; Centre Hospitalier Régional Universitaire de Brest (CHRU Brest); Département des sciences en santé environnementale (DEESSE); Fondation de France 2014-50537, 00110196; French Biomedicine Agency |
| Source: |
ISSN: 0268-1161. |
| Publisher Information: |
HAL CCSD; Oxford University Press (OUP) |
| Publication Year: |
2023 |
| Collection: |
Université de Rennes 1: Publications scientifiques (HAL) |
| Subject Terms: |
ovarian reserve; female infertility; persistent organic pollutants; environmental exposure; pesticides; polychlorinated biphenyls; [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| Description: |
International audience ; STUDY QUESTION Are persistent organic pollutants (POPs) associated with a diminished ovarian reserve (DOR) in women of reproductive age? SUMMARY ANSWER Amongst 17 POPs detected in over 20% of serum samples, only p,p '-DDE was significantly associated with an increased risk of DOR, and beta-hexachlorocyclohexane (beta-HCH) was significantly associated with a decreased risk of DOR whilst mixture analyses yielded non-significant associations and did not detect any interactions between POPs. WHAT IS KNOWN ALREADY Animal studies have shown that several POPs can alter folliculogenesis and increase follicle depletion. However, only a few studies have been conducted in humans, with small sample sizes and inconsistent results. STUDY DESIGN, SIZE, DURATION Our study included 138 cases and 151 controls from the AROPE case-control study. Study participants were women between 18 and 40 years of age recruited amongst couples consulting for infertility in four fertility centres in western France between 2016 and 2020. PARTICIPANTS/MATERIALS, SETTING, METHODS Cases of DOR were defined as women with anti-Mullerian hormone (AMH) levels |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36881900; PUBMED: 36881900 |
| DOI: |
10.1093/humrep/dead028 |
| Availability: |
https://hal.science/hal-04058970; https://hal.science/hal-04058970v1/document; https://hal.science/hal-04058970v1/file/Genard-Walton%202023%20Serum%20persistent%20organic%20pollutants%20and%20diminished%20ovarian%20reserve%20_HUMREP-22-0623.R3.pdf; https://doi.org/10.1093/humrep/dead028 |
| Rights: |
http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.34E8111D |
| Database: |
BASE |