| Title: |
Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy |
| Authors: |
Lo Iacono M.; Modica C.; Porcelli G.; Brancato O. R.; Muratore G.; Bianca P.; Gaggianesi M.; Turdo A.; Veschi V.; Todaro M.; Di Franco S.; Stassi G. |
| Contributors: |
Lo Iacono M.; Modica C.; Porcelli G.; Brancato O.R.; Muratore G.; Bianca P.; Gaggianesi M.; Turdo A.; Veschi V.; Todaro M.; Di Franco S.; Stassi G. |
| Publisher Information: |
MDPI |
| Publication Year: |
2022 |
| Collection: |
IRIS Università degli Studi di Palermo |
| Subject Terms: |
adipokines; adipose tissue; cancer stem cells; exosomes; target therapy; tumor microenvironment; Settore MED/46 - Scienze Tecniche Di Medicina Di Laboratorio; Settore MED/50 - Scienze Tecniche Mediche Applicate |
| Description: |
The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of TME, and contributes to cancer development and progression. Cancer-associated adipocytes (CAAs), reprogrammed by cancer stem cells (CSCs), drive cancer progression by releasing metabolites and inflammatory adipokines. In this review, we highlight the mechanisms underlying the bidirec-tional crosstalk among CAAs, CSCs, and stromal cells. Moreover, we focus on the recent advances in the therapeutic targeting of adipocyte-released factors as an innovative strategy to counteract cancer progression. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35625629; info:eu-repo/semantics/altIdentifier/wos/WOS:000801755600001; volume:12; issue:5; numberofpages:19; journal:BIOMOLECULES; https://hdl.handle.net/10447/557957 |
| DOI: |
10.3390/biom12050702 |
| Availability: |
https://hdl.handle.net/10447/557957; https://doi.org/10.3390/biom12050702 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.3560B6D9 |
| Database: |
BASE |