| Title: |
Percutaneous revascularization for ischemic left ventricular dysfunction: Cost-effectiveness analysis of the REVIVED-BCIS2 trial |
| Authors: |
Chivardi, Carlos; Morgan, Holly; Sculpher, Mark J.; Clayton, Tim; Evans, Richard; Dodd, Matthew; Petrie, Mark; Rinaldi, Christopher A.; O'Kane, Peter; Brown, Louise; Perera, Divaka; Saramago, Pedro; Chiribiri, Amedeo; Carr-White, Gerry; Pavlidis, Antonis; Redwood, Simon; Clapp, Brian; Rinaldi, Aldo; Rahman, Haseeb; Briceno, Natalia; Arnold, Sophie; Raynsford, Amy; Wilson, Karen; Clack, Lucy; McEntegart, Margaret; Watkins, Stuart; Shaukat, Aadil; Rocchiccioli, Paul; McAdam, Marion; McPherson, Elizabeth; Cowan, Louise; Wood, Marie; Weerackody, Roshan; Davies, Ceri; Smith, Elliot; Modi, Bhavik; Mathew, Bindu; Mitchelmore, Oliver; Adrego, Rita; Andiapen, Mervyn; O’Kane, Peter; Din, Jehangir; Kennard, Sarah; Orr, Sarah; Purnell, Cathie; Greenwood, John; Blaxill, Jonathan; Mozid, Abdul; Anderson, Michelle; Somers, Kathryn; Dixon, Lana; Walsh, Simon; Spence, Mark; Glover, Patricia; Brown, Caroline; Amin-Youssef, George; Shah, Ajay; McDonagh, Theresa; Byrne, Jonathan; Pareek, Nilesh; Breeze, Jonathan; Antao, Catherine; De Silva, Kalpa; Strange, Julian; Johnson, Tom; Nightingale, Angus; Gallego, Laura; Medina, Cristina; Gershlick, Anthony; McCann, Gerald; Ladwiniec, Andrew; Squire, Iain; Davison, Joanna; Kenmuir-Hogg, Kris; Spratt, James; Cosgrove, Claudia; Williams, Rupert; Firoozi, Sam; Lim, Pitt; Bonato, Giovanna; Sookhoo, Vennessa; Conway, Dwayne; Brooksby, Paul; Wright, Judith; Exley, Donna; Cotton, James; Horton, Richard; Metherell, Stella; Smallwood, Andrew; Hogrefe, Kai; Cheng, Adrian; Beirnes, Charmaine; Sidgwick, Sian; Lockie, Tim; Patel, Niket; Rakhit, Roby; Davies, Nina; Smit, Angelique; Ahmed, Fozia; Hendry, Cara; Fath-Odoubadi, Farzin; Fraser, Douglas; Mamas, Mamas; Oommen, Anu; Charles, Thabitha; Behan, Miles; Japp, Alan; Rif, Belinda; Jenkins, Nicholas; McClure, Sam; Oates, Pauline; Martin, Karen; Abdelaal, Eltigani; Sarma, Jaydeep; Shastri, Sanjay; Riley, Jo; Giannopoulou, Sarra; Quinn, Sophie; Magapu, Pradeep; Stables, Rod; Wright, David; Barton, Janet; Clarkson, Nichola; Mahmoudi, Michael; Flett, Andrew; Curzen, Nick; Radmore, Judith; Gough, Sam; Ludman, Andrew; Kurdi, Hibba; Keenan, Samantha; Banerjee, Prithwish; Tapp, Luke; Edwards, Nigel; Gibson, Catherine; Kukreja, Neville; Lynch, Mary; Barratt, Claire; de Belder, Mark; Thambyrajah, Jeet; Swanson, Neil; Richardson, Cath; Atkinson, Bev; Viswanathan, Girish; Waugh, Darren; Routledge, Helen; Trevelyan, Jasper; Doughty, Angela; Pegge, Nick; Dhamrait, Sukhbir; Moore, Sally; Galasko, Gavin; Cassidy, Christopher; Waddington, Natalia; Edwards, Tim; Iqbal, Javed; Witherow, Fraser; Birch, Jenny; Munro, Melanie; Wells, Tim; Sinha, Manas; Frost, Linda; Lee, Kaeng; Beattie, James; Pitt, Mike; Chung, Alan; Ramcharitar, Steve; McCafferty, Laura; Martin, Thomas; Irving, John; Iskandar, Zaid; Hutcheon, Anita; Gunn, Julian; Al-Mohammad, Abdallah; Agyemang, Michael; Griffiths, Huw; Kalra, Paul; Howe, Serena; Gray, Tim; Sobolewska, Jolanta; Morby, Louise; Glover, Jason; Beynon, James; Knight, Janet; Das, Paul; Bellamy, Chris; Harman, Emily; Pye, Mr Maurice; Megarry, Simon; McGill, Yvonne; Redfearn, Heidi |
| Publisher Information: |
American Heart Association |
| Publication Year: |
2024 |
| Collection: |
University of Glasgow: Enlighten - Publications |
| Description: |
BACKGROUND: Percutaneous coronary intervention (PCI) is frequently undertaken in patients with ischemic left ventricular systolic dysfunction. The REVIVED (Revascularization for Ischemic Ventricular Dysfunction)-BCIS2 (British Cardiovascular Society-2) trial concluded that PCI did not reduce the incidence of all-cause death or heart failure hospitalization; however, patients assigned to PCI reported better initial health-related quality of life than those assigned to optimal medical therapy (OMT) alone. The aim of this study was to assess the cost-effectiveness of PCI+OMT compared with OMT alone. METHODS: REVIVED-BCIS2 was a prospective, multicenter UK trial, which randomized patients with severe ischemic left ventricular systolic dysfunction to either PCI+OMT or OMT alone. Health care resource use (including planned and unplanned revascularizations, medication, device implantation, and heart failure hospitalizations) and health outcomes data (EuroQol 5-dimension 5-level questionnaire) on each patient were collected at baseline and up to 8 years post-randomization. Resource use was costed using publicly available national unit costs. Within the trial, mean total costs and quality-adjusted life-years (QALYs) were estimated from the perspective of the UK health system. Cost-effectiveness was evaluated using estimated mean costs and QALYs in both groups. Regression analysis was used to adjust for clinically relevant predictors. RESULTS: Between 2013 and 2020, 700 patients were recruited (mean age: PCI+OMT=70 years, OMT=68 years; male (%): PCI+OMT=87, OMT=88); median follow-up was 3.4 years. Over all follow-ups, patients undergoing PCI yielded similar health benefits at higher costs compared with OMT alone (PCI+OMT: 4.14 QALYs, £22 352; OMT alone: 4.16 QALYs, £15 569; difference: −0.015, £6782). For both groups, most health resource consumption occurred in the first 2 years post-randomization. Probabilistic results showed that the probability of PCI being cost-effective was 0. CONCLUSIONS: A minimal difference in ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://eprints.gla.ac.uk/317298/1/317298.pdf; Chivardi, C. et al. (2024) Percutaneous revascularization for ischemic left ventricular dysfunction: Cost-effectiveness analysis of the REVIVED-BCIS2 trial. Circulation: Cardiovascular Quality and Outcomes , 17(1), e010533. (doi:10.1161/circoutcomes.123.010533 ) (PMID:37929587) (PMCID:PMC10782932) |
| DOI: |
10.1161/circoutcomes.123.010533 |
| Availability: |
https://eprints.gla.ac.uk/317298/; https://eprints.gla.ac.uk/317298/1/317298.pdf; https://doi.org/10.1161/circoutcomes.123.010533 |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.35821F68 |
| Database: |
BASE |