| Title: |
Longitudinal Multiparametric Quantitative MRI Evaluation of Acute and Chronic Multiple Sclerosis Paramagnetic Rim Lesions |
| Authors: |
Elkady, Ahmed M.; Elliott, Colm; Fetco, Dumitru; Araujo, David; Karimaghaloo, Zahra; Ganzetti, Marco; Clayton, David; Craveiro, Licinio; Kazlauskaite, Agne; Narayanan, Sridar; Arnold, Douglas L.; Rudko, David A. |
| Contributors: |
U.S. Department of Defense; Canada First Research Excellence Fund; Mitacs |
| Source: |
Journal of Magnetic Resonance Imaging ; ISSN 1053-1807 1522-2586 |
| Publisher Information: |
Wiley |
| Publication Year: |
2024 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Background Multiple sclerosis (MS) paramagnetic rim lesions (PRLs) are markers of chronic active biology and exhibit complex iron and myelin changes that may complicate quantification when using conventional MRI approaches. Purpose To conduct a multiparametric MRI analysis of PRLs. Study Type Retrospective/longitudinal. Subjects Ninety‐five progressive MS subjects with at least one persistent PRL who were enrolled in the CONSONANCE trial. Field Strength/Sequence 3‐T/Susceptibility‐weighted, T1‐weighted, T2‐weighted, and fluid‐attenuated inversion recovery. Assessment Acute/chronic PRLs and non‐PRLs were measured at screening, 24, 48, and 96 weeks using quantitative magnetic susceptibility (QS), R2*, and standardized T1w/T2w ratio (sT1w/T2w). PRL analyses were performed for whole lesion, core, and rim. The correlations between PRL core and rim sT1w/T2w, QS, and R2* were assessed. Statistical Tests Linear mixed models. A P ‐value |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/jmri.29583 |
| Availability: |
https://doi.org/10.1002/jmri.29583; https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmri.29583 |
| Rights: |
http://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.358A7003 |
| Database: |
BASE |