Does Syphilis Increase the Risk of HIV-RNA Elevation >200 Copies/mL in HIV-Positive Patients under Effective Antiretroviral Treatment? Data from the ICONA Cohort
| Title: | Does Syphilis Increase the Risk of HIV-RNA Elevation >200 Copies/mL in HIV-Positive Patients under Effective Antiretroviral Treatment? Data from the ICONA Cohort |
|---|---|
| Authors: | Giacomelli A.; Cozzi-Lepri A.; Cingolani A.; Tavelli A.; Mazzotta V.; Tesoro D.; Bassetti M.; Castagna A.; Di Biagio A.; Lichter M.; Monforte A. D'.; Rusconi S; Icona Foundation Study Group (A d'Arminio Monforte; A Antinori; S Antinori; A Castagna; R Cauda; G Di Perri; E Girardi; R Iardino; A Lazzarin; G C Marchetti; C Mussini; E Quiros-Roldan; L Sarmati; B Suligoi; F von Schloesser; P Viale; A d'Arminio Monforte; F Ceccherini-Silberstein; A Cingolani; A Cozzi-Lepri; A Di Biagio; A Gori; S Lo Caputo; G Marchetti; F Maggiolo; M Puoti; C F Perno; C Torti; F Bai; A Bandera; S Bonora; A Calcagno; D Canetti; A Cervo; P Cinque; R Gagliardini; A Giacomelli; N Gianotti; G Guaraldi; S Lanini; G Lapadula; M Lichtner; A Lai; G Madeddu; V Malagnino; A Mondi; V Mazzotta; S Nozza; S Piconi; C Pinnetti; E Quiros Roldan; R Rossotti; S Rusconi; M M Santoro; A Saracino; V Spagnuolo; N Squillace; V Svicher; L Taramasso; A Vergori; S De Benedittis; I Fanti; M Giotta; C Marelli; A Rodano'; A Tavelli; M Cernuschi; L Cosmaro; A Perziano; V Calvino; D Russo; M Farinella; N Policek; V L Del Negro; M Augello; S Carrara; S Graziano; G Prota; S Truffa; D Vincenti; R Rovito; A Giacometti; A Costantini; V Barocci; C Santoro; E Milano; L Comi; C Suardi; L Badia; S Cretella; E M Erne; A Pieri; E Focà; C Minardi; B Menzaghi; C Abeli; L Chessa; F Pes; P Maggi; L Alessio; G Nunnari; B M Celesia; J Vecchiet; K Falasca; A Pan; S Dal Zoppo; D Segala; M A Di Pietro; C Costa; S Ferrara; M Bassetti; E Pontali; S Blanchi; N Bobbio; G Mazzarello; L Fondaco; C Molteni; G Canavesi; G Pellicanò; G Rizzardini; V Bono; M V Cossu; R Lolatto; M C Moioli; L Pezzati; S Diotallevi; C Tincati; M Menozzi; P Bonfanti; V Sangiovanni; I Gentile; V Esposito; N Coppola; F M Fusco; G Di Filippo; V Rizzo; N Sangiovanni; S Martini; A M Cattelan; D Leoni; A Cascio; M Trizzino; D Francisci; E Schiaroli; G Parruti; F Sozio; D Messeri; S I Bonelli; C Lazzaretti; R Corsini; C Mastroianni; A Latini; I Mastrorosa; S Lamonica; M Capozzi; M Camici; M Rivano Capparuccia; G Iaiani; C Stingone; L Gianserra; J Paulicelli; M M Plazzi; G d'Ettore; M Fusto; I Coledan; A De Vito; M Fabbiani; F Montagnani; A Franco; R Fontana Del Vecchio; B M Pasticci; C Di Giuli; G C Orofino; G Calleri; G Accardo; C Tascini; A Londero; G Battagin; S Nicolè; G Starnini; S Dell'Isola). ). |
| Contributors: | A., Giacomelli; A., Cozzi-Lepri; A., Cingolani; A., Tavelli; V., Mazzotta; D., Tesoro; M., Bassetti; A., Castagna; A., Di Biagio; M., Lichter; A. D'., Monforte; S, Rusconi; Foundation Study Group (A d'Arminio Monforte, Icona; Antinori, A; Antinori, S; Castagna, A; Cauda, R; Di Perri, G; Girardi, E; Iardino, R; Lazzarin, A; C Marchetti, G; Mussini, C; Quiros-Roldan, E; Sarmati, L; Suligoi, B; Von Schloesser, F; Viale, P; D'Arminio Monforte, A; Ceccherini-Silberstein, F; Cingolani, A; Cozzi-Lepri, A; Di Biagio, A; Gori, A; Lo Caputo, S; Marchetti, G; Maggiolo, F; Puoti, M; F Perno, C; Torti, C; Bai, F; Bandera, A; Bonora, S; Calcagno, A; Canetti, D; Cervo, A; Cinque, P; Gagliardini, R; Giacomelli, A; Gianotti, N; Guaraldi, G; Lanini, S; Lapadula, G; Lichtner, M; Lai, A; Madeddu, G; Malagnino, V; Mondi, A; Mazzotta, V; Nozza, S; Piconi, S; Pinnetti, C; Quiros Roldan, E; Rossotti, R; Rusconi, S; M Santoro, M; Saracino, A; Spagnuolo, V; Squillace, N; Svicher, V; Taramasso, L; Vergori, A; De Benedittis, S; Fanti, I; Giotta, M; Marelli, C; Rodano', A; Tavelli, A |
| Publication Year: | 2021 |
| Collection: | Università degli Studi di Cagliari: UNICA IRIS |
| Subject Terms: | HIV; PLWH; STDs; syphilis; TasP; viral rebound |
| Description: | Background:To assess the impact of syphilis infection on the risk of HIV-RNA elevation in people living with HIV (PLWH) with current HIV-RNA ≤50 copies/mL.Setting:The Italian Cohort Naive Antiretrovirals.Methods:All PLWH (2009-2020) under antiretroviral treatment with at least 2 consecutive HIV-RNA values ≤50 copies/mL before the date of syphilis diagnosis and at least 1 HIV-RNA determination after the syphilis event were enrolled. A control group of PLWH without syphilis was matched for mode of HIV transmission. Outcomes were defined using the first HIV-RNA measure in the time window ranging between -2 and +6 months of the diagnosis/index date. The primary outcome used a single value >200 copies/mL to define HIV-RNA elevation associated with risk of transmission. The association between syphilis infection and the protocol defined outcome was evaluated using logistic regression analysis.Results:Nine hundred twenty-six PLWH with a syphilis event were enrolled and matched with a random sample of 1370 PLWH without syphilis. Eighteen of the 926 (1.9%) with syphilis had ≥1 HIV-RNA >200 copies/mL in the window vs. 29/1370 (2.1%) of the not exposed (P = 0.77). In the multivariable analysis adjusted for age, year of diagnosis/index date, and clinical site, syphilis infection was not associated with the risk of HIV-RNA >200 copies/mL (adjusted odds ratio 0.81; 95% confidence interval 0.43-1.52, P = 0.508).Conclusions:We did not find any evidence for an association between syphilis infection and viral elevation >200 copies/mL. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34138773; info:eu-repo/semantics/altIdentifier/wos/WOS:000711669200006; volume:88; issue:2; firstpage:132; lastpage:137; numberofpages:6; journal:JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES; https://hdl.handle.net/11584/451545 |
| DOI: | 10.1097/QAI.0000000000002749 |
| Availability: | https://hdl.handle.net/11584/451545; https://doi.org/10.1097/QAI.0000000000002749 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.35CBA6C5 |
| Database: | BASE |