| Source: |
Artzi-Medvedik, R, Kob, R, Screening for CKD among Older People across Europe (SCOPE) study investigators , Di Rosa, M, Lattanzio, F, Corsonello, A, Yehoshua, I, Roller-Wirnsberger, R E, Wirnsberger, G H, Mattace-Raso, F U S, Tap, L, Gil, P G, Formiga, F, Moreno-González, R, Kostka, T, Guligowska, A, Ärnlöv, J, Carlsson, A C, Freiberger, E & Melzer, I 2023, 'Quality of Life and Kidney Function in Older Adults : Prospective Data of the SCOPE Study', Journal of Clinical Medicine, vol. 12, no. 12, 3959. https://doi.org/10.3390/jcm12123959 |
| Description: |
A longitudinal alteration in health-related quality of life (HRQoL) over a two-year period and its association with early-stage chronic kidney disease (CKD) progression was investigated among 1748 older adults (>75 years). HRQoL was measured by the Euro-Quality of Life Visual Analog Scale (EQ-VAS) at baseline and at one and two years after recruitment. A full comprehensive geriatric assessment was performed, including sociodemographic and clinical characteristics, the Geriatric Depression Scale-Short Form (GDS-SF), Short Physical Performance Battery (SPPB), and estimated glomerular filtration rate (eGFR). The association between EQ-VAS decline and covariates was investigated by multivariable analyses. A total of 41% of the participants showed EQ-VAS decline, and 16.3% showed kidney function decline over the two-year follow-up period. Participants with EQ-VAS decline showed an increase in GDS-SF scores and a greater decline in SPPB scores. The logistic regression analyses showed no contribution of a decrease in kidney function on EQ-VAS decline in the early stages of CKD. However, older adults with a greater GDS-SF score were more likely to present EQ-VAS decline over time, whereas an increase in the SPPB scores was associated with less EQ-VAS decline. This finding should be considered in clinical practice and when HRQoL is used to evaluate health interventions among older adults. |