Supplementary information files for 'Post-Hospitalisation COVID-19 Rehabilitation (PHOSP-R): a randomised controlled trial of exercise-based rehabilitation'
| Title: | Supplementary information files for 'Post-Hospitalisation COVID-19 Rehabilitation (PHOSP-R): a randomised controlled trial of exercise-based rehabilitation' |
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| Authors: | Enya Daynes; Rachael A. Evans; Neil J Greening; Nicolette Bishop; Thomas Yates; Daniel Lozano-Rojas; Kimon Ntotsis; Matthew Richardson; Molly M Baldwin; Malik Hamrouni; Emily Hume; Hamish McAuley; George Mills; Dimitrios Megaritis; Matthew Roberts; Charlotte E Bolton; James D Chalmers; Trudie Chalder; Annemarie B. Docherty; Omer Elneima; Ewen M Harrison; Victoria C Harris; Ling P Ho; Alex Horsley; Linzy Houchen-Wolloff; Olivia C Leavy; Michael Marks; Krishna Poinasamy; Jennifer K Quint; Betty Raman; Ruth M Saunders; Aarti Shikotra; Amisha Singapuri; Marco Sereno; Sarah Terry; Louise V Wain; William D-C Man; Carlos Echevarria; Ioannis Vogiatzis; Christopher Brightling; Sally J. Singh |
| Publication Year: | 2025 |
| Collection: | The University of Auckland: Figshare |
| Subject Terms: | Biomedical and clinical sciences; Cardiovascular medicine and haematology; Respiratory system; COVID-19; Post-COVID syndrome; Exercise-based rehabilitation interventions; Controlled trial |
| Description: | Supplementary files for article "Post-Hospitalisation COVID-19 Rehabilitation (PHOSP-R): a randomised controlled trial of exercise-based rehabilitation" Objective : Post-COVID syndrome involves prolonged symptoms with multisystem and functional impairment lasting ≥12 weeks after acute coronavirus disease 2019 (COVID-19). We aimed to determine the efficacy of exercise-based rehabilitation interventions, either face-to-face or remote, compared to usual care in individuals experiencing post-COVID syndrome following a hospitalisation with acute COVID-19. Design: This single-blind randomised controlled trial compared two exercise-based rehabilitation interventions (face-to-face or remote) to usual care in participants with post-COVID syndrome following a hospitalisation. The interventions were either a face-to-face or remote 8-week programme of individually prescribed exercise and education. The primary outcome was the change in Incremental Shuttle Walking Test (ISWT) following 8 weeks of intervention (either face-to-face or remote) compared to usual care. Other secondary outcomes were measured including health-related quality of life (HRQoL), and exploratory outcomes included lymphocyte immunotyping. Results : 181 participants (55% male, mean±sdage 59±12 years, length of hospital stay 12±19 days) were randomised. There was an improvement in the ISWT distance following face-to-face rehabilitation (mean 52 m, 95% CI 19–85 m; p=0.002) and remote rehabilitation (mean 34 m, 95% CI 1–66 m; p=0.047) compared to usual care alone. There were no differences between groups for HRQoL self-reported symptoms. Analysis of immune markers revealed significant increases in naïve and memory CD8+T-cells following face-to-face rehabilitationversususual care alone (p |
| Document Type: | dataset |
| Language: | unknown |
| DOI: | 10.17028/rd.lboro.29425178.v1 |
| Availability: | https://doi.org/10.17028/rd.lboro.29425178.v1; https://figshare.com/articles/dataset/Supplementary_information_files_for_Post-Hospitalisation_COVID-19_Rehabilitation_PHOSP-R_a_randomised_controlled_trial_of_exercise-based_rehabilitation_/29425178 |
| Rights: | CC BY 4.0 |
| Accession Number: | edsbas.36C4A76F |
| Database: | BASE |