| Title: |
Clusterin and pentraxin 3 are markers of severity during febrile neutropenia in adults with haematological malignancies receiving intensive chemotherapy |
| Authors: |
Mallebranche, Coralie; Mosnier, Carole; Orvain, Corentin; Riou, Jérémie; Thepot, Sylvain; Pignon, Pascale; Blanchard, Simon; Tortevoie, Nathalie; Pellier, Isabelle; Hunault-Berger, Mathilde; Jeannin, Pascale; Delneste, Yves; Schmidt-Tanguy, Aline; Beauvillain, Céline |
| Contributors: |
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers (CRCI2NA); Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE); Nantes Université - pôle Santé; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ); Centre Hospitalier Universitaire d'Angers (CHU Angers); Fédérations hospitalo-universitaires Grand Ouest Acute Leukemia Angers (FHU GOAL); Innate Immunity and Immunotherapy (CRCI2NA / Eq 4); Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE); Université d'Angers (UA) |
| Source: |
ISSN: 0007-1048. |
| Publisher Information: |
CCSD; Wiley |
| Publication Year: |
2025 |
| Collection: |
Université de Nantes: HAL-UNIV-NANTES |
| Subject Terms: |
infection; leukemia; neutropenia; sepsis; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Summary The identification of predictive biomarkers of severity can improve patient management because febrile neutropenia can be associated with significant morbidity and mortality. We prospectively studied pentraxin 3 (PTX3), a soluble innate immunity receptor, and clusterin (CLU), a chaperone protein that binds extracellular histones during sepsis, in patients experiencing febrile neutropenia after intensive treatment for haematological malignancies. One hundred and forty‐three adult patients were included, with 158 episodes of neutropenia analysed. Febrile neutropenia was observed in 119 patients (75%), including 62 without sepsis (group 1; 53%), 42 with sepsis (group 2; 35%) and 14 with severe sepsis/septic shock (group 3; 12%) (missing data, MD): (1) Among these patients, 94 patients had a quick Sequencial Organ Failure Assessment score (qSOFA) |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40722110; PUBMED: 40722110; PUBMEDCENTRAL: PMC12436219 |
| DOI: |
10.1111/bjh.70002 |
| Availability: |
https://inserm.hal.science/inserm-05467931; https://inserm.hal.science/inserm-05467931v1/document; https://inserm.hal.science/inserm-05467931v1/file/Br%20J%20Haematol%20-%202025%20-%20Mallebranche.pdf; https://doi.org/10.1111/bjh.70002 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.36DD16B7 |
| Database: |
BASE |