| Title: |
Impaired slow oscillation, sleep spindle, and slow oscillation-spindle coordination in patients with idiopathic restless legs syndrome |
| Authors: |
Cha, KS; Kim, TJ; Jun, JS; Byun, JI; Sunwoo, JS; Shin, JW; Kim, KH; Lee, SK; Jung, KY |
| Contributors: |
112418; Kim, TJ |
| Publication Year: |
2020 |
| Subject Terms: |
Arousal; Electroencephalography; Female; Humans; Male; Middle Aged; Polysomnography; Restless Legs Syndrome; Surveys and Questionnaires; Sleep disturbance; Sleep spindles; Slow oscillations; Wake after sleep onset |
| Description: |
OBJECTIVES: Thalamocortical abnormalities have been implicated in the pathophysiology of restless legs syndrome (RLS). We hypothesized that sleep spindle and slow oscillation (SO) activity is impaired in RLS, and that this dysfunction may contribute to sleep disturbance in these patients. To address this issue, we characterized sleep spindle and SO activity in RLS. METHODS: Fifteen drug-naive, idiopathic RLS patients (13 female and 2 male) and 15 female healthy controls participated in this study. Nineteen-channel electroencephalograms were obtained during polysomnographic (PSG) recordings. An automated sleep spindle and SO detection algorithm was used to detect sleep spindle (12-16 Hz) and SO ( |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
J013899457; http://repository.ajou.ac.kr/handle/201003/22787 |
| DOI: |
10.1016/j.sleep.2019.09.021 |
| Availability: |
http://repository.ajou.ac.kr/handle/201003/22787; https://doi.org/10.1016/j.sleep.2019.09.021 |
| Accession Number: |
edsbas.36F7AF51 |
| Database: |
BASE |