| Title: |
The involvement of ZnT‐1, a new modulator of cardiac L‐type calcium channels, in remodeling atrial tachycardia |
| Authors: |
Beharier, Ofer; Etzion, Yoram; Levi, Shiri; Mor, Merav; Mor, Michal; Dror, Shani; Kahn, Joy; Katz, Amos; Moran, Arie |
| Source: |
Annals of the New York Academy of Sciences ; volume 1188, issue 1, page 87-95 ; ISSN 0077-8923 1749-6632 |
| Publisher Information: |
Wiley |
| Publication Year: |
2010 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Atrial fibrillation (AF), the highest occurring cardiac arrhythmia in the Western world, is associated with substantial morbidity and increased mortality. In spite of extensive research, the cause of atrial electrical remodeling, a major factor in the self‐perpetuating nature of AF, is still unknown. Downregulation of L‐type Ca 2+ channel (LTCC) activity is the hallmark of atrial electrical remodeling. ZnT‐1 is a ubiquitous membrane protein that was recently suggested to inhibit the LTCC. We have studied and shown that ZnT‐1 expression inhibits LTCC function in an oocyte expression system as well as in isolated cardiomyocytes. Our data also show that rapid electrical pacing can augment ZnT‐1 expression in culture as well as in the atria of rats in vivo . Finally, in a pilot study, ZnT‐1 expression was found to be augmented in the atria of AF patients. These findings position ZnT‐1 as a probable missing link in the mechanism underlying atrial tachycardia remodeling. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/j.1749-6632.2009.05087.x |
| Availability: |
https://doi.org/10.1111/j.1749-6632.2009.05087.x; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1749-6632.2009.05087.x; https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.2009.05087.x |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.373BF87F |
| Database: |
BASE |