| Title: |
Construct validity of real-world digital mobility outcomes in patients after proximal femoral fracture: a cross-sectional observational study |
| Authors: |
Eckert, T.; Berge, M.A.; Long, M.; de las Heras, M.; Alvarez, P.; Blain, H.; Braun, J.; Buekers, J.; Caulfield, B.; Engdal, M.; Frei, A.; Helbostad, J.L.; Ionescu, A.; Jansen, C.-P.; Johnsen, L.G.; Klenk, J.; Koch, S.; Lanfranchi, V.; Rochester, L.; Becker, C.; Vereijken, B.; Garcia-Aymerich, J. |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2026 |
| Collection: |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
| Description: |
Digital mobility outcomes (DMOs) offer unique insights into recovery of real-world mobility after proximal femoral fracture (PFF), but their clinical validity remains to be established. This study assessed construct validity (convergent, divergent, and known-groups) of 24 DMOs measuring walking activity (amount, pattern) and gait (pace, rhythm, bout-to-bout variability) in patients within one year after PFF. Patients were recruited from inpatient and outpatient lists at five European sites, resulting in 505 included participants (66% female), with mean age of 77.6 ± 9.4 years and supervised gait speed of 0.7 ± 0.4 m/s. Mobility was monitored over seven days using a single wearable device on the lower back. Convergent and divergent validity analyses were stratified by two groups: acute (≤ 14 days since surgery) and non-acute (≥ 15 days since surgery). Correlations between DMOs and related (clinical- and patient-reported mobility outcomes) and unrelated constructs (hearing impairment and systolic blood pressure) were compared to a priori expected correlations. Known-groups validity was assessed across four recovery phases. The results were evaluated individually by experts and in a subsequent consensus meeting, with 17 of 24 DMOs showing evidence of construct validity in non-acute PFF patients. These findings represent an initial step in a larger process towards regulatory endorsement. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
2045-2322 |
| Relation: |
https://eprints.whiterose.ac.uk/id/eprint/239623/1/s41598-026-43297-y.pdf; Eckert, T., Berge, M.A., Long, M. orcid.org/0000-0001-5943-3415 et al. (19 more authors) (2026) Construct validity of real-world digital mobility outcomes in patients after proximal femoral fracture: a cross-sectional observational study. Scientific Reports, 16 (1). 9535. ISSN: 2045-2322 |
| Availability: |
https://eprints.whiterose.ac.uk/id/eprint/239623/ |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.37EC9A92 |
| Database: |
BASE |