Additional file 7 of Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma
| Title: | Additional file 7 of Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma |
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| Authors: | Benjamin Lin; Abigail K. Shelton; Erin Smithberger; Julia Ziebro; Kasey R. Skinner; Ryan E. Bash; Richard Kirkman; Allie Stamper; Madison Butler; Alex Flores; Steven P. Angus; Michael P. East; Timothy F. Cloughesy; David A. Nathanson; Michael E. Berens; Jann N. Sarkaria; Zev A. Binder; Donald M. O’Rourke; Timothy C. Howton; Brittany N. Lasseigne; Christopher D. Willey; Gary L. Johnson; Anita B. Hjelmeland; Frank B. Furnari; C. Ryan Miller |
| Publication Year: | 2025 |
| Collection: | The University of Auckland: Figshare |
| Subject Terms: | Biochemistry; Medicine; Genetics; Pharmacology; Biotechnology; Marine Biology; Cancer; Hematology; Virology; Computational Biology; Biological Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; EGFR; Glioblastoma; Synthetic lethality; Kinome rewiring; Upfront combinatorial therapy |
| Description: | Supplementary Material 7: Fig. S6 Kinase signature protein and mRNA levels correlate in drug-resistant cells cultured in full serum. Scatter plots of genes in baseline kinase signatures (Table ST. 5) show significant Pearson correlations between protein and mRNA Log2FC values in the following resistant lines compared to parental CEv3 cells: E4 (A), E5 (B), G1 (C), G5 (D), G8 (E), and G12 (F) |
| Document Type: | still image |
| Language: | unknown |
| DOI: | 10.6084/m9.figshare.29432002.v1 |
| Availability: | https://doi.org/10.6084/m9.figshare.29432002.v1; https://figshare.com/articles/figure/Additional_file_7_of_Identifying_and_exploiting_combinatorial_synthetic_lethality_by_characterizing_adaptive_kinome_rewiring_of_EGFRvIII-driven_glioblastoma/29432002 |
| Rights: | CC BY |
| Accession Number: | edsbas.3825A388 |
| Database: | BASE |