| Title: |
Circulating extra-cellular RNAs and atrial fibrillation: data from the TRACE-CORE cohort |
| Authors: |
Tak, Katherine; Lessard, Darleen; Kiefe, Catarina I; Freedman, Jane E; Parker, Matthew; Aurigemma, Gerard P; Donahue, Kevin; McManus, David D; Tran, Khanh-Van |
| Contributors: |
Medicine; Population and Quantitative Health Sciences; Biostatistics and Health Services Research |
| Source: |
Frontiers in cardiovascular medicine ; 12 ; 1623112 ; Switzerland |
| Publication Year: |
2025 |
| Collection: |
University of Massachusetts, Medical School: eScholarship@UMMS |
| Subject Terms: |
adverse cardiac remodeling; atrial fibrillation; biomarker; echophenotypes; microRNA |
| Description: |
Background: Atrial fibrillation (AF) is the most common sustained arrhythmia and is linked to increased risk of stroke, heart failure, and mortality. Circulating extracellular RNAs (exRNAs), which regulate gene expression and reflect underlying biological processes, are potential biomarkers for atrial fibrillation. Methods: As part of an ongoing, larger study into extracellular RNAs (exRNAs) as potential biomarkers for cardiovascular disease, we analyzed exRNA profiles in a subset of 296 survivors of acute coronary syndrome (ACS) enrolled in the Transitions, Risks, and Actions in Coronary Events Center for Outcomes Research and Education (TRACE-CORE) cohort. A total of 318 exRNAs were quantified, selected a priori based on prior findings from the Framingham Heart Study. We assessed associations between circulating exRNAs and echocardiographic intermediate phenotypes relevant to atrial fibrillation (AF), including left atrial dimension, left ventricular (LV) mass, LV end-diastolic volume, and global longitudinal strain. Subsequently, we used logistic regression models to evaluate whether the exRNAs associated with these phenotypes were also associated with a history of AF (n = 18, 5.4%). Downstream bioinformatics analyses were performed to identify putative target genes, enriched gene ontology categories, and molecular pathways regulated by these candidate microRNAs. Results: We identified 77 extracellular RNAs (exRNAs) that were significantly associated with increased left ventricular (LV) mass and at least one additional echocardiographic intermediate phenotype. Among these, miR-17-5p and miR-574-3p were also significantly associated with a history of atrial fibrillation (AF), with odds ratios of 1.58 (95% CI: 1.10-2.26) and 2.16 (95% CI: 1.03-4.54), respectively. Predicted gene targets of these miRNAs were enriched in pathways implicated in atrial remodeling and arrhythmogenesis. Key overlapping canonical pathways included the Senescence Pathway, Idiopathic Pulmonary Fibrosis Signaling, ERK5 Signaling, RHO ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Frontiers in Cardiovascular Medicine; https://doi.org/10.3389/fcvm.2025.1623112; https://hdl.handle.net/20.500.14038/54673 |
| DOI: |
10.3389/fcvm.2025.1623112 |
| Availability: |
https://doi.org/10.3389/fcvm.2025.1623112; https://hdl.handle.net/20.500.14038/54673 |
| Rights: |
© 2025 Tak, Lessard, Kiefe, Freedman, Parker, Aurigemma, Donahue, McManus and Tran. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.3826597 |
| Database: |
BASE |