| Title: |
Associations between stroke type, ischemic stroke subtypes, and poststroke cognitive trajectories |
| Authors: |
Levine, DA; Whitney, RT; Ye, W; Briceño, EM; Gross, AL; Giordani, BJ; Sussman, JB; Lazar, RM; Howard, VJ; Aparicio, HJ; Beiser, AS; Elkind, MSV; Gottesman, RF; Koton, S; Pendlebury, S; Kollipara, AS; Springer, MV; Seshadri, S; Romero, JR; Fitzpatrick, AL; Longstreth, WT; Hayward, RA |
| Publisher Information: |
Lippincott, Williams & Wilkins |
| Publication Year: |
2025 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
BACKGROUND: It is unclear how poststroke cognitive trajectories differ by stroke type and ischemic stroke subtype. We studied associations between stroke types (ischemic and hemorrhagic), ischemic stroke subtypes (cardioembolic, large artery atherosclerotic, lacunar/small vessel, and cryptogenic/other determined causes), and poststroke cognitive decline. METHODS: We pooled participants from 4 US cohort studies (1971–2019). Outcomes were change in global cognition (primary) and changes in executive function and memory (secondary). Outcomes were standardized as T scores (mean [SD], 50 [10]); a 1-point difference represents a 0.1 SD difference in cognition. The median follow-up for the primary outcome was 6.0 (interquartile range, 3.2–9.2) years. Linear mixed-effects models estimated changes in cognition after stroke. RESULTS: We identified 1143 dementia-free individuals with acute stroke during follow-up: 1061 (92.8%) ischemic, 82 (7.2%) hemorrhagic, 49.9% female, and 30.8% Black. The median age at stroke was 74.1 (interquartile range, 68.6–79.3) years. On average, ischemic stroke survivors showed declines in global cognition (−0.35 [95% CI, −0.43 to −0.27] points/y; P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1161/strokeaha.124.047640 |
| DOI: |
10.1161/strokeaha.124.047640 |
| Availability: |
https://doi.org/10.1161/strokeaha.124.047640; https://ora.ox.ac.uk/objects/uuid:eaf463cc-d1f9-4731-85dd-d135f16c4e98 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.388E7E7B |
| Database: |
BASE |