| Title: |
Colorectal polyps:Targets for fluorescence-guided endoscopy to detect high-grade dysplasia and T1 colorectal cancer |
| Authors: |
Dekkers, Nik; Zonoobi, Elham; Dang, Hao; Warmerdam, Mats I.; Crobach, Stijn; Langers, Alexandra M.J.; van der Kraan, Jolein; Hilling, Denise E.; Peeters, Koen C.M.J.; Holman, Fabian A.; Vahrmeijer, Alexander L.; Sier, Cornelis F.M.; Hardwick, James C.H.; Boonstra, Jurjen J. |
| Source: |
Dekkers, N, Zonoobi, E, Dang, H, Warmerdam, M I, Crobach, S, Langers, A M J, van der Kraan, J, Hilling, D E, Peeters, K C M J, Holman, F A, Vahrmeijer, A L, Sier, C F M, Hardwick, J C H & Boonstra, J J 2023, 'Colorectal polyps : Targets for fluorescence-guided endoscopy to detect high-grade dysplasia and T1 colorectal cancer', United European Gastroenterology Journal, vol. 11, no. 3, pp. 282-292. https://doi.org/10.1002/ueg2.12375 |
| Publication Year: |
2023 |
| Subject Terms: |
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being |
| Description: |
Background: Differentiating high-grade dysplasia (HGD) and T1 colorectal cancer (T1CRC) from low-grade dysplasia (LGD) in colorectal polyps can be challenging. Incorrect recognition of HGD or T1CRC foci can lead to a need for additional treatment after local resection, which might not have been necessary if it was recognized correctly. Tumor-targeted fluorescence-guided endoscopy might help to improve recognition. Objective: Selecting the most suitable HGD and T1CRC-specific imaging target from a panel of well-established biomarkers: carcinoembryonic antigen (CEA), c-mesenchymal-epithelial transition factor (c-MET), epithelial cell adhesion molecule (EpCAM), folate receptor alpha (FRα), and integrin alpha-v beta-6 (αvβ6). Methods: En bloc resection specimens of colorectal polyps harboring HGD or T1CRC were selected. Immunohistochemistry on paraffin sections was used to determine the biomarker expression in normal epithelium, LGD, HGD, and T1CRC (scores of 0–12). The differential expression in HGD-T1CRC components compared to surrounding LGD and normal components was assessed, just as the sensitivity and specificity of each marker. Results: 60 specimens were included (21 HGD, 39 T1CRC). Positive expression (score >1) of HGD-T1CRC components was found in 73.3%, 78.3%, and 100% of cases for CEA, c-MET, and EpCAM, respectively, and in |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
2050-6406; 2050-6414 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36931635; info:eu-repo/semantics/altIdentifier/pissn/2050-6406; info:eu-repo/semantics/altIdentifier/eissn/2050-6414 |
| DOI: |
10.1002/ueg2.12375 |
| Availability: |
https://pure.eur.nl/en/publications/6c6909aa-9ec5-4717-a2fd-1a318e8fc825; https://doi.org/10.1002/ueg2.12375; https://pure.eur.nl/ws/files/87220080/Colorectal_polyps_Targets_for_fluorescence_guided_endoscopy_to_detect_high_grade_dysplasia_and_T1_colorectal_cancer.pdf; https://www.scopus.com/pages/publications/85150790034 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.38AFF0C7 |
| Database: |
BASE |